Selected Publications

(For a full list of publications, please visit http://www.ncbi.nlm.nih.gov/pubmed)

Rajani R, Pastor-Soler NM, Hallows KR. Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 Jun 12. doi: 10.1097/MNH.0000000000000349. [Epub ahead of print]

Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017 Apr 20;8:227. doi: 10.3389/fphys.2017.00227. eCollection 2017.

Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F890-F900. doi: 10.1152/ajprenal.00308.2016. Epub 2016 Aug 17.
Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 Oct 26;6:35952. doi: 10.1038/srep35952.

Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn A, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. Am J Physiol Renal Physiol. 2016 Aug 17:ajprenal.00308.2016. doi:10.1152/ajprenal.00308.2016. Epub 2016 Aug 27.

Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells.
Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1216-28. doi: 10.1152/ajprenal.00061.2016. Epub 2016 Feb 24.

Muc1 enhances the beta-catenin protective pathway during ischemia-reperfusion injury.
Al-Bataineh MM, Kinlough CL, Poland PA, Pastor-Soler NM, Sutton TA, Mang HE, Bastacky SI, Gendler SJ, Madsen CS, Singh S, Monga SP, Hughey RP. Am J Physiol Renal Physiol. 2016 Jan 6:ajprenal.00520.2015. doi: 10.1152/ajprenal.00520.2015. [Epub ahead of print]

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. J Clin Invest. 2015 Sep;125(9):3433-48. doi: 10.1172/JCI75245. Epub 2015 Aug 4.

Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Jiang C, Veon W, Li H, Hallows KR, Roy P. Cell Cycle. 2015;14(18):2914-23. doi: 10.1080/15384101.2015.1069929. Epub 2015 Jul 15.

Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F414-28. doi: 10.1152/ajprenal.00463.2014. Epub 2015 Jul 1.

Muc1 is protective during kidney ischemia-reperfusion injury. Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Am J Physiol Renal Physiol. 2015 Jun 15;308(12):F1452-62. doi: 10.1152/ajprenal.00066.2015. Epub 2015 Apr 29.

Collecting duct intercalated cell function and regulation. Roy A, Al-bataineh MM, Pastor-Soler NM. Clin J Am Soc Nephrol. 2015 Feb 6;10(2):305-24. doi: 10.2215/CJN.08880914. Epub 2015 Jan 28.

Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Morrell ED, Kellum JA, Pastor-Soler NM, Hallows KR. Crit Care. 2014 Sep 2;18(5):501. doi: 10.1186/s13054-014-0501-5. Review.

Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24.

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler NM, Gardella TJ, Vilardaga JP. Nat Chem Biol. 2014 Sep;10(9):707-9. doi: 10.1038/nchembio.1589. Epub 2014 Jul 27.

Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Raghavan V, Rbaibi Y, Pastor-Soler NM, Carattino MD, Weisz OA. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8506-11. doi: 10.1073/pnas.1402195111. Epub 2014 May 27.

Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase. Al-bataineh MM, Gong F, Marciszyn AL, Myerburg MM, Pastor-Soler NM. Am J Physiol Renal Physiol. 2014 May 1;306(9):F981-95. doi: 10.1152/ajprenal.00362.2013. Epub 2014 Feb 19.

Epithelial transport during septic acute kidney injury. Morrell ED, Kellum JA, Hallows KR, Pastor-Soler NM. Nephrol Dial Transplant. 2014 Jul;29(7):1312-9. doi: 10.1093/ndt/gft503. Epub 2013 Dec 29. Review.

Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Păunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1783-95. doi: 10.1152/ajprenal.00622.2012. Epub 2013 Oct 16.

Opening lines of communication in the distal nephron. Kleyman TR, Satlin LM, Hallows KR.
J Clin Invest. 2013 Oct;123(10):4139-41. doi: 10.1172/JCI71944. Epub 2013 Sep 24.

Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase. Wang Z, Subramanya AR, Satlin LM, Pastor-Soler NM, Carattino MD, Kleyman TR. Am J Physiol Cell Physiol. 2013 Oct 15;305(8):C846-53. doi: 10.1152/ajpcell.00133.2013. Epub 2013 Jul 24.

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.
Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD Jr, Hallows KR, Brown D, Bouley R, Vilardaga JP. J Biol Chem. 2013 Sep 27;288(39):27849-60. doi: 10.1074/jbc.M112.445098. Epub 2013 Aug 9.

AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM.
Am J Physiol Renal Physiol. 2013 Oct 1;305(7):F943-56. doi: 10.1152/ajprenal.00303.2013. Epub 2013 Jul 17.

Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. King JD Jr, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows KR. J Biol Chem. 2012 Sep 28;287(40):33389-400. Epub 2012 Aug 6.

AMP-activated protein kinase regulation of kidney tubular transport. Pastor-Soler NM, Hallows KR. Curr Opin Nephrol Hypertens. 2012 Sep;21(5):523-33. doi: 10.1097/MNH.0b013e3283562390. Review.

Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. J Biol Chem. 2011 Oct 28;286(43):37830-40. doi: 10.1074/jbc.M111.293233. Epub 2011 Sep 7.

CFTR regulation by phosphorylation. Alzamora R, King JD Jr, Hallows KR.
Methods Mol Biol. 2011;741:471-88. doi: 10.1007/978-1-61779-117-8_29.

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. Am J Physiol Renal Physiol. 2010 Dec;299(6):F1308-19. doi: 10.1152/ajprenal.00423.2010. Epub 2010 Sep 22.

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. Cell. 2010 Jul 23;142(2):270-83. doi: 10.1016/j.cell.2010.06.007.

SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy.
Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. J Mol Cell Cardiol. 2010 Oct;49(4):683-92. doi: 10.1016/j.yjmcc.2010.06.003. Epub 2010 Jun 20.

PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. J Biol Chem. 2010 Aug 6;285(32):24676-85. doi: 10.1074/jbc.M110.106278. Epub 2010 Jun 4.

Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D.
J Biol Chem. 2010 Jul 9;285(28):21671-8. doi: 10.1074/jbc.M109.084731. Epub 2010 May 13.

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. Am J Physiol Renal Physiol. 2010 Jul;299(1):F167-77. doi: 10.1152/ajprenal.00162.2010. Epub 2010 May 12.

Role of the energy sensor AMP-activated protein kinase in renal physiology and disease.
Hallows KR, Mount PF, Pastor-Soler NM, Power DA. Am J Physiol Renal Physiol. 2010 May;298(5):F1067-77. doi: 10.1152/ajprenal.00005.2010. Epub 2010 Feb 24. Review.

Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. Am J Physiol Renal Physiol. 2010 May;298(5):F1162-9. doi: 10.1152/ajprenal.00645.2009. Epub 2010 Feb 10.

AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Myerburg MM, King JD Jr, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows KR. Am J Respir Cell Mol Biol. 2010 Jun;42(6):676-84. doi: 10.1165/2009-0147OC. Epub 2009 Jul 17.

AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. King JD Jr, Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows KR.
Am J Physiol Cell Physiol. 2009 Jul;297(1):C94-101. doi: 10.1152/ajpcell.00677.2008. Epub 2009 May 6.

AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. Am J Physiol Cell Physiol. 2009 Apr;296(4):C672-81. doi: 10.1152/ajpcell.00004.2009. Epub 2009 Feb 11.

Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. J Biol Chem. 2009 Feb 27;284(9):5774-83. doi: 10.1074/jbc.M805501200. Epub 2009 Jan 6.

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR. J Biol Chem. 2009 Jan 2;284(1):150-7. doi: 10.1074/jbc.M807358200. Epub 2008 Nov 3.

Mechanisms of ENaC regulation and clinical implications. Bhalla V, Hallows KR.
J Am Soc Nephrol. 2008 Oct;19(10):1845-54. doi: 10.1681/ASN.2008020225. Epub 2008 Aug 27. Review.

Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. Am J Physiol Cell Physiol. 2008 Feb;294(2):C488-94. Epub 2007 Dec 26.

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. J Biol Chem. 2006 Sep 8;281(36):26159-69. Epub 2006 Jul 14.

Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation.
Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM. J Biol Chem. 2006 Feb 17;281(7):4231-41. Epub 2005 Dec 18.

Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Hallows KR. Curr Opin Nephrol Hypertens. 2005 Sep;14(5):464-71. Review.

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR. J Biol Chem. 2005 May 6;280(18):17608-16. Epub 2005 Mar 7.

(For a full list of publications, please visit http://www.ncbi.nlm.nih.gov/pubmed)