Faculty

Richard M Watanabe

Richard M Watanabe

Professor of Population and Public Health Sciences;Associate Dean for Health and Population Science Programs
Medicine
CSC 2250 Alcazar St Health Sciences Campus Los Angeles

Associations Between Perceived Stress and Cortisol Biomarkers in Predominantly Latino Adolescents Res Sq. 2024 Nov 15. . View in PubMed

Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of ß-Cell Function in an East Asian Population Diabetes Care. 2024 Aug 01; 47(8):1386-1394. . View in PubMed

Mind- and Body-Based Interventions Improve Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis J Integr Complement Med. 2023 Feb; 29(2):69-79. . View in PubMed

A saturated map of common genetic variants associated with human height Nature. 2022 10; 610(7933):704-712. . View in PubMed

Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Nat Commun. 2021 Feb 08; 12(1):995. . View in PubMed

The trans-ancestral genomic architecture of glycemic traits Nat Genet. 2021 06; 53(6):840-860. . View in PubMed

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis J Hepatol. 2021 01; 74(1):20-30. . View in PubMed

Corrigendum: Insulin Action, Glucose Homeostasis and Free Fatty Acid Metabolism: Insights From a Novel Model Front Endocrinol (Lausanne). 2021; 12:789390. . View in PubMed

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Nat Commun. 2021 01 05; 12(1):24. . View in PubMed

Insulin Action, Glucose Homeostasis and Free Fatty Acid Metabolism: Insights From a Novel Model Front Endocrinol (Lausanne). 2021; 12:625701. . View in PubMed

Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach Prostaglandins Other Lipid Mediat. 2020 06; 148:106410. . View in PubMed

Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium Obesity (Silver Spring). 2019 08; 27(8):1331-1337. . View in PubMed

A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile Br J Nutr. 2018 12; 120(11):1230-1239. . View in PubMed

Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans Obesity (Silver Spring). 2018 04; 26(4):703-712. . View in PubMed

Association of weight gain and fifteen adipokines with declining beta-cell function in Mexican Americans PLoS One. 2018; 13(8):e0201568. . View in PubMed

Physiologic Interpretation of GWAS Signals for Type 2 Diabetes Methods Mol Biol. 2018; 1706:323-351. . View in PubMed

Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS) Sci Rep. 2018 04 04; 8(1):5603. . View in PubMed

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls Sci Data. 2018 01 23; 5:180002. . View in PubMed

Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota J Nutr Biochem. 2017 11; 49:8-14. . View in PubMed

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants Diabetes. 2017 08; 66(8):2296-2309. . View in PubMed

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk Diabetes. 2017 07; 66(7):2019-2032. . View in PubMed

Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection AIDS Res Hum Retroviruses. 2017 07; 33(7):723-727. . View in PubMed

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2301-2306. . View in PubMed

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls Sci Data. 2017 12 19; 4:170179. . View in PubMed

Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans Diabetes Care. 2016 Apr; 39(4):547-54. . View in PubMed

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium Diabetes. 2016 07; 65(7):2072-80. . View in PubMed

The genetic architecture of type 2 diabetes Nature. 2016 08 04; 536(7614):41-47. . View in PubMed

The genetic regulatory signature of type 2 diabetes in human skeletal muscle Nat Commun. 2016 06 29; 7:11764. . View in PubMed

An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes Endocrinology. 2015 Sep; 156(9):3147-56. . View in PubMed

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium Diabetes. 2015 May; 64(5):1853-66. . View in PubMed

Variation in PPARG is associated with longitudinal change in insulin resistance in Mexican Americans at risk for type 2 diabetes J Clin Endocrinol Metab. 2015 Mar; 100(3):1187-95. . View in PubMed

Adults with long-duration type 2 diabetes have blunted glycemic and ß-cell function improvements after bariatric surgery Obesity (Silver Spring). 2015 Mar; 23(3):523-6. . View in PubMed

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus PLoS Genet. 2015 Jan; 11(1):e1004876. . View in PubMed

A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS) PLoS One. 2015; 10(11):e0134649. . View in PubMed

High calorie intake is associated with worsening insulin resistance and ß-cell function in Hispanic women after gestational diabetes mellitus Diabetes Care. 2014 Dec; 37(12):3294-300. . View in PubMed

Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women AIDS. 2014 Jul 31; 28(12):1815-23. . View in PubMed

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans Diabetologia. 2014 Jul; 57(7):1391-9. . View in PubMed

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity Diabetes. 2014 Jun; 63(6):2158-71. . View in PubMed

Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans Obesity (Silver Spring). 2014 Apr; 22(4):1157-64. . View in PubMed

Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus Diabetologia. 2013 Dec; 56(12):2753-60. . View in PubMed

Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: analysis of a randomized control trial comparing surgery with intensive medical treatment Diabetes Care. 2013 Aug; 36(8):2175-82. . View in PubMed

High-fat diet is associated with obesity-mediated insulin resistance and ß-cell dysfunction in Mexican Americans J Nutr. 2013 Apr; 143(4):479-85. . View in PubMed

Self-reported physical activity is associated with ß-cell function in Mexican American adults Diabetes Care. 2013 Mar; 36(3):638-44. . View in PubMed

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion Nat Genet. 2013 Feb; 45(2):197-201. . View in PubMed

Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans Obesity (Silver Spring). 2012 Oct; 20(10):2083-92. . View in PubMed

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways Nat Genet. 2012 Sep; 44(9):991-1005. . View in PubMed

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance Nat Genet. 2012 May 13; 44(6):659-69. . View in PubMed

Estimating hepatic glucokinase activity using a simple model of lactate kinetics Diabetes Care. 2012 May; 35(5):1015-20. . View in PubMed

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels Diabetes. 2012 May; 61(5):1291-6. . View in PubMed

Pancreatic iron and glucose dysregulation in thalassemia major Am J Hematol. 2012 Feb; 87(2):155-60. . View in PubMed

A genome-wide association search for type 2 diabetes genes in African Americans PLoS One. 2012; 7(1):e29202. . View in PubMed

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals PLoS Genet. 2012; 8(3):e1002607. . View in PubMed

Deterioration in cardiometabolic risk markers in obese women during depot medroxyprogesterone acetate use Contraception. 2012 Jan; 85(1):36-41. . View in PubMed

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes Diabetes. 2011 Oct; 60(10):2624-34. . View in PubMed

Drugs, diabetes and pharmacogenomics: the road to personalized therapy Pharmacogenomics. 2011 May; 12(5):699-701. . View in PubMed

A better index of body adiposity Obesity (Silver Spring). 2011 May; 19(5):1083-9. . View in PubMed

Genome Med. 2011 Mar 25; 3(3):18. . View in PubMed

Statistical issues in gene association studies Methods Mol Biol. 2011; 700:17-36. . View in PubMed

A principal components-based clustering method to identify variants associated with complex traits Hum Hered. 2011; 71(1):50-8. . View in PubMed

A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans Am J Clin Nutr. 2010 Dec; 92(6):1359-68. . View in PubMed

The genetics of insulin resistance: Where's Waldo? Curr Diab Rep. 2010 Dec; 10(6):476-84.. View in PubMed

Limitations in surrogate measures of insulin resistance J Clin Endocrinol Metab. 2010 Nov; 95(11):4874-6. . View in PubMed

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Nat Genet. 2010 Nov; 42(11):949-60. . View in PubMed

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet. 2010 Nov; 42(11):937-48. . View in PubMed

Pharmacogenetics of Anti-Diabetes Drugs Pharmaceuticals (Basel). 2010 Aug 01; 3(8):2610-2646. . View in PubMed

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis Nat Genet. 2010 Jul; 42(7):579-89. . View in PubMed

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans Diabetes. 2010 May; 59(5):1266-75. . View in PubMed

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet. 2010 Feb; 42(2):142-8. . View in PubMed

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet. 2010 Feb; 42(2):105-16. . View in PubMed

A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies BMC Proc. 2009 Dec 15; 3 Suppl 7:S129. . View in PubMed

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose Diabetes. 2009 Dec; 58(12):2946-53. . View in PubMed

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. . View in PubMed

Obesity attenuates the contribution of African admixture to the insulin secretory profile in peripubertal children: a longitudinal analysis Obesity (Silver Spring). 2009 Jul; 17(7):1318-25. . View in PubMed

Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans Obesity (Silver Spring). 2009 Apr; 17(4):729-36. . View in PubMed

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation Nat Genet. 2009 Jan; 41(1):25-34. . View in PubMed

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion Nat Genet. 2009 Jan; 41(1):82-8. . View in PubMed

Variants in MTNR1B influence fasting glucose levels Nat Genet. 2009 Jan; 41(1):77-81. . View in PubMed

OGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself Obesity (Silver Spring). 2008 Aug; 16(8):1938-45. . View in PubMed

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels J Clin Invest. 2008 Jul; 118(7):2620-8. . View in PubMed

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet. 2008 May; 40(5):638-45. . View in PubMed

Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans Diabetes. 2008 Apr; 57(4):1048-56. . View in PubMed

Newly identified loci that influence lipid concentrations and risk of coronary artery disease Nat Genet. 2008 Feb; 40(2):161-9. . View in PubMed

Common variants in the GDF5-UQCC region are associated with variation in human height Nat Genet. 2008 Feb; 40(2):198-203. . View in PubMed

Prioritized subset analysis: improving power in genome-wide association studies Hum Hered. 2008; 65(3):129-41. . View in PubMed

Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes Diabetes. 2007 Dec; 56(12):3027-32. . View in PubMed

What is gestational diabetes? Diabetes Care. 2007 Jul; 30 Suppl 2:S105-11.. View in PubMed

Genetics of gestational diabetes mellitus and type 2 diabetes Diabetes Care. 2007 Jul; 30 Suppl 2:S134-40. . View in PubMed

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science. 2007 Jun 01; 316(5829):1341-5. . View in PubMed

Reduction in added sugar intake and improvement in insulin secretion in overweight latina adolescents Metab Syndr Relat Disord. 2007 Jun; 5(2):183-93. . View in PubMed

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans Diabetes. 2007 May; 56(5):1481-5. . View in PubMed

Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q Hum Hered. 2007; 63(1):17-25. . View in PubMed

Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes Diabetes. 2007 Jan; 56(1):256-64. . View in PubMed

Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns Diabetes. 2006 Sep; 55(9):2534-40. . View in PubMed

Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 *3/*3 non-expressors Transpl Immunol. 2006 Jan; 15(3):235-40. . View in PubMed

Sequence variation in PPARG may underlie differential response to troglitazone Diabetes. 2005 Nov; 54(11):3319-25. . View in PubMed

Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns Hum Genet. 2005 Nov; 118(2):245-54. . View in PubMed

Ordered subset analysis in genetic linkage mapping of complex traits Genet Epidemiol. 2004 Jul; 27(1):53-63. . View in PubMed

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study Diabetes Care. 2004 Jun; 27(6):1365-8. . View in PubMed

Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects Diabetes Care. 2004 Jun; 27(6):1369-74. . View in PubMed

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes Diabetes. 2004 Apr; 53(4):1141-9. . View in PubMed

A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14 Diabetes. 2004 Mar; 53(3):821-9. . View in PubMed

Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin Diabetes. 2003 Aug; 52(8):2168-74. . View in PubMed

MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test Diabetes Technol Ther. 2003; 5(6):1003-15. . View in PubMed

Insulin resistance and associated compensatory responses in african-american and Hispanic children Diabetes Care. 2002 Dec; 25(12):2184-90. . View in PubMed

Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort Diabetes. 2002 May; 51(5):1644-8. . View in PubMed

Glucose tolerance during moderate alcohol intake: insights on insulin action from glucose/lactate dynamics J Clin Endocrinol Metab. 2002 Mar; 87(3):1233-8. . View in PubMed

I have a primary interest in the pathophysiology and genetics of type 2 diabetes mellitus. My research program focuses on genetics, pathophysiology (and the correlation with genetics), and mathematical modeling of physiologic systems.

In the area of complex disease genetics, I am focusing on both positional cloning of susceptibility genes for type 2 diabetes and diabetes-related traits and understanding the gene-phenotype relationships and how they are impacted by environmental exposures.
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