Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations Diabetologia. 2024 Sep 30. . View in PubMed

Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions Am J Hum Genet. 2024 Aug 21. . View in PubMed

Hierarchical joint analysis of marginal summary statistics-Part II: High-dimensional instrumental analysis of omics data Genet Epidemiol. 2024 Jun 17. . View in PubMed

Inferring causal cell types of human diseases and risk variants from candidate regulatory elements medRxiv. 2024 May 18. . View in PubMed

Improved multi-ancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk medRxiv. 2024 Apr 16. . View in PubMed

A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children Cell Genom. 2024 Apr 10; 4(4):100526. . View in PubMed

Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia Hum Mol Genet. 2024 Apr 08; 33(8):687-697. . View in PubMed

A rigorous benchmarking of alignment-based HLA typing algorithms for RNA-seq data bioRxiv. 2024 Jan 16. . View in PubMed

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data Nat Commun. 2024 Jan 15; 15(1):522. . View in PubMed

Novel insight into the etiology of ischemic stroke gained by integrative multiome-wide association study Hum Mol Genet. 2024 Jan 07; 33(2):170-181. . View in PubMed

Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis Arthritis Res Ther. 2024 02 10; 26(1):47. . View in PubMed

SuSiE PCA: A scalable Bayesian variable selection technique for principal component analysis iScience. 2023 Nov 17; 26(11):108181. . View in PubMed

A likelihood-based framework for demographic inference from genealogical trees bioRxiv. 2023 Oct 13. . View in PubMed

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy bioRxiv. 2023 Jun 04. . View in PubMed

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics bioRxiv. 2023 Apr 18. . View in PubMed

Tree-based QTL mapping with expected local genetic relatedness matrices bioRxiv. 2023 Apr 08. . View in PubMed

Novel insight into the etiology of ischemic stroke gained by integrative transcriptome-wide association study medRxiv. 2023 Mar 31. . View in PubMed

A scalable variational approach to characterize pleiotropic components across thousands of human diseases and complex traits using GWAS summary statistics medRxiv. 2023 Mar 29. . View in PubMed

The motif composition of variable number tandem repeats impacts gene expression Genome Res. 2023 04; 33(4):511-524. . View in PubMed

twas_sim, a Python-based tool for simulation and power analysis of transcriptome-wide association analysis Bioinformatics. 2023 05 04; 39(5). . View in PubMed

Tree-based QTL mapping with expected local genetic relatedness matrices Am J Hum Genet. 2023 12 07; 110(12):2077-2091. . View in PubMed

A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics Am J Hum Genet. 2023 11 02; 110(11):1863-1874. . View in PubMed

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics Am J Hum Genet. 2023 11 02; 110(11):1853-1862. . View in PubMed

Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions J Natl Cancer Inst. 2023 06 08; 115(6):712-732. . View in PubMed

Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia Leukemia. 2022 03; 36(3):865-868. . View in PubMed

Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits Mol Psychiatry. 2022 03; 27(3):1394-1404. . View in PubMed

A genealogical estimate of genetic relationships Am J Hum Genet. 2022 05 05; 109(5):812-824. . View in PubMed

Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood Clin Epigenetics. 2022 12 01; 14(1):158. . View in PubMed

Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies Am J Hum Genet. 2022 08 04; 109(8):1388-1404. . View in PubMed

Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia Hum Mol Genet. 2022 10 28; 31(21):3741-3756. . View in PubMed

Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children Haematologica. 2022 09 01; 107(9):2266-2270. . View in PubMed

Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL Blood Adv. 2022 06 28; 6(12):3756-3766. . View in PubMed

A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk Int J Cancer. 2022 01 01; 150(1):80-90. . View in PubMed

Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Genome Med. 2021 Aug 30; 13(1):139. . View in PubMed

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 Mar; 53(3):413. . View in PubMed

Multitrait transcriptome-wide association study (TWAS) tests Genet Epidemiol. 2021 09; 45(6):563-576. . View in PubMed

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies PLoS Genet. 2021 04; 17(4):e1008973. . View in PubMed

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 01; 53(1):65-75. . View in PubMed

Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry J Natl Cancer Inst. 2021 09 04; 113(9):1168-1176. . View in PubMed

H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility Am J Hum Genet. 2021 12 02; 108(12):2284-2300. . View in PubMed

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Genome Med. 2021 08 02; 13(1):123. . View in PubMed

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization Nat Commun. 2021 07 27; 12(1):4569. . View in PubMed

A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis Am J Epidemiol. 2021 06 01; 190(6):1148-1158. . View in PubMed

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization medRxiv. 2020 Dec 08. . View in PubMed

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms Cell. 2020 Apr 30; 181(3):745. . View in PubMed

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms Cell. 2020 Apr 16; 181(2):484. . View in PubMed

The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study Front Genet. 2020; 11:540724. . View in PubMed

Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data Am J Hum Genet. 2020 06 04; 106(6):805-817. . View in PubMed

Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI Genet Epidemiol. 2019 09; 43(6):629-645. . View in PubMed

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture Nat Genet. 2019 08; 51(8):1244-1251. . View in PubMed

Probabilistic fine-mapping of transcriptome-wide association studies Nat Genet. 2019 04; 51(4):675-682. . View in PubMed

Opportunities and challenges for transcriptome-wide association studies Nat Genet. 2019 04; 51(4):592-599. . View in PubMed

Genome-Wide Meta-analysis of Gene-Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women Cancer Prev Res (Phila). 2019 01; 12(1):31-42. . View in PubMed

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease MechanismsCell. 2019 10 17; 179(3):750-771. e22. . View in PubMed

Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization PLoS One. 2019; 14(6):e0218917. . View in PubMed

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights Nat Genet. 2018 04; 50(4):538-548. . View in PubMed

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum Nat Commun. 2018 03 21; 9(1):1178. . View in PubMed

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits Am J Hum Genet. 2018 10 04; 103(4):535-552. . View in PubMed

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions Nat Commun. 2018 10 04; 9(1):4079. . View in PubMed

Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits Am J Hum Genet. 2017 Nov 02; 101(5):737-751. . View in PubMed

Targeted mutagenesis in a human-parasitic nematode PLoS Pathog. 2017 Oct; 13(10):e1006675. . View in PubMed

Enhanced methods to detect haplotypic effects on gene expression Bioinformatics. 2017 Aug 01; 33(15):2307-2313. . View in PubMed

Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits Am J Hum Genet. 2017 Mar 02; 100(3):473-487. . View in PubMed

A multi-stage genome-wide association study of uterine fibroids in African Americans Hum Genet. 2017 10; 136(10):1363-1373. . View in PubMed

The contribution of rare variation to prostate cancer heritability Nat Genet. 2016 Jan; 48(1):30-5. . View in PubMed

Accurate viral population assembly from ultra-deep sequencing data Bioinformatics. 2014 Jun 15; 30(12):i329-37. . View in PubMed

Reconstruction of viral population structure from next-generation sequencing data using multicommodity flows BMC Bioinformatics. 2013; 14 Suppl 9:S2. . View in PubMed