Faculty

Marlena Fejzo

Marlena Fejzo

Clinical Assistant Professor of Population and Public Health Sciences in the Center for Genetic Epidemiology
Genetic Epidemiology
1845 N. Soto Street Health Sciences Campus Los Angeles

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Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes Trends Mol Med. 2024 Jun; 30(6):530-540. . View in PubMed

GDF15 linked to maternal risk of nausea and vomiting during pregnancy Nature. 2024 Jan; 625(7996):760-767. . View in PubMed

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy bioRxiv. 2023 Jun 04. . View in PubMed

Pregnant, miserable, and starving in 21st century America AJOG Glob Rep. 2023 Feb; 3(1):100141. . View in PubMed

Author's reply BJOG. 2023 06; 130(7):843-844. . View in PubMed

Inaccuracies in "Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis" Am J Obstet Gynecol. 2022 Nov; 227(5):792. . View in PubMed

Patterns of Use and Self-reported Effectiveness of Cannabis for Hyperemesis Gravidarum Geburtshilfe Frauenheilkd. 2022 May; 82(5):517-527. . View in PubMed

Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum BJOG. 2022 10; 129(11):1845-1852. . View in PubMed

Analysis in epithelial ovarian cancer identifies KANSL1 as a biomarker and target gene for immune response and HDAC inhibition Gynecol Oncol. 2021 02; 160(2):539-546. . View in PubMed

HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study Geburtshilfe Frauenheilkd. 2021 Jan; 81(1):90-98. . View in PubMed

A core outcome set for hyperemesis gravidarum studies is a small step in the right direction BJOG. 2020 07; 127(8):993. . View in PubMed

Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality Geburtshilfe Frauenheilkd. 2019 Apr; 79(4):382-388. . View in PubMed

Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder Reprod Toxicol. 2019 03; 84:59-64. . View in PubMed

Nausea and vomiting of pregnancy and hyperemesis gravidarum Nat Rev Dis Primers. 2019 09 12; 5(1):62. . View in PubMed

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum Geburtshilfe Frauenheilkd. 2018 Sep; 78(9):866-870. . View in PubMed

Critique of inaccurate reporting in Edlavitch article on "Publishing negative findings and the challenge of avoiding type II errors in studies of suspect teratogens: Example of a recent ondansetron publication" Reprod Toxicol. 2018 01; 75:144-145. . View in PubMed

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum Nat Commun. 2018 03 21; 9(1):1178. . View in PubMed

Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi Genes Chromosomes Cancer. 2017 08; 56(8):589-597. . View in PubMed

Measures of depression and anxiety in women with hyperemesis gravidarum are flawed Evid Based Nurs. 2017 07; 20(3):78-79. . View in PubMed

Analysis of pre- and post-pregnancy issues in women with hyperemesis gravidarum Auton Neurosci. 2017 01; 202:73-78. . View in PubMed

Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2) Mol Cell Endocrinol. 2017 01 05; 439:308-316. . View in PubMed

Response to the questions submitted by MrReichmann. Reprod Toxicol. 2016 12; 66:123. . View in PubMed

Ondansetron in pregnancy and risk of adverse fetal outcomes in the United States Reprod Toxicol. 2016 07; 62:87-91. . View in PubMed

Intestinal obstruction is a rare complication of ondansetron exposure in hyperemesis gravidarum Reprod Toxicol. 2015 Nov; 57:207. . View in PubMed

ADRM1-amplified metastasis gene in gastric cancer Genes Chromosomes Cancer. 2015 Aug; 54(8):506-515. . View in PubMed

Neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum Eur J Obstet Gynecol Reprod Biol. 2015 Jun; 189:79-84. . View in PubMed

Psychiatric factors do not affect recurrence risk of hyperemesis gravidarum J Obstet Gynaecol Res. 2015 Apr; 41(4):512-6. . View in PubMed

KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition Br J Cancer. 2014 Oct 28; 111(9):1788-801. . View in PubMed

POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer Gynecol Oncol. 2014 Feb; 132(2):334-42. . View in PubMed

Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum Eur J Obstet Gynecol Reprod Biol. 2013 Sep; 170(1):71-6. . View in PubMed

Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer Int J Mol Sci. 2013 Feb 01; 14(2):3094-109. . View in PubMed

Dacomitinib, an irreversible Pan-ErbB inhibitor significantly abrogates growth in head and neck cancer models that exhibit low response to cetuximab PLoS One. 2013; 8(2):e56112. . View in PubMed

Hyperemesis gravidarum: it is time to put an end to the misguided theory of a psychiatric etiology Gen Hosp Psychiatry. 2012 Nov-Dec; 34(6):699-700; author reply 700-1. . View in PubMed

No increased risk of psychological/behavioral disorders in siblings of women with hyperemesis gravidarum (HG) unless their mother had HG J Dev Orig Health Dis. 2012 Oct; 3(5):375-9. . View in PubMed

Change in paternity and recurrence of hyperemesis gravidarum J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1241-5. . View in PubMed

Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum J Matern Fetal Neonatal Med. 2012 Jun; 25(6):632-6. . View in PubMed

Posttraumatic stress symptoms following pregnancy complicated by hyperemesis gravidarum J Matern Fetal Neonatal Med. 2011 Nov; 24(11):1307-11. . View in PubMed

Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood J Dev Orig Health Dis. 2011 Aug; 2(4):200-4. . View in PubMed

Knockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK Genes Chromosomes Cancer. 2011 Jun; 50(6):434-41. . View in PubMed

Familial aggregation of hyperemesis gravidarumAm J Obstet Gynecol. 2011 Mar; 204(3):230. e1-7. . View in PubMed

Recurrence risk of hyperemesis gravidarum J Midwifery Womens Health. 2011 Mar-Apr; 56(2):132-6. . View in PubMed

Periostin promotes ovarian cancer angiogenesis and metastasis Gynecol Oncol. 2010 Nov; 119(2):337-44. . View in PubMed

Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo Clin Cancer Res. 2010 Mar 01; 16(5):1509-19. . View in PubMed

Tissue microarrays from frozen tissues-OCT technique Methods Mol Biol. 2010; 664:73-80. . View in PubMed

Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case seriesFertil Steril. 2010 Jan; 93(1):267. e9-11. . View in PubMed

Symptoms and pregnancy outcomes associated with extreme weight loss among women with hyperemesis gravidarum J Womens Health (Larchmt). 2009 Dec; 18(12):1981-7. . View in PubMed

High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals Eur J Obstet Gynecol Reprod Biol. 2008 Nov; 141(1):13-7. . View in PubMed

Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target Genes Chromosomes Cancer. 2008 Oct; 47(10):873-83. . View in PubMed

Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells Br J Cancer. 2008 Mar 25; 98(6):1076-84. . View in PubMed

The psychosocial burden of hyperemesis gravidarum J Perinatol. 2008 Mar; 28(3):176-81. . View in PubMed

Secular trends in the treatment of hyperemesis gravidarum Am J Perinatol. 2008 Mar; 25(3):141-7. . View in PubMed

RIN1 is a breast tumor suppressor gene Cancer Res. 2007 Dec 15; 67(24):11510-6. . View in PubMed

Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum Contraception. 2007 Dec; 76(6):451-5. . View in PubMed

Marlena Schoenberg Fejzo, Ph.D. is a medical scientist whose research focuses on conditions and diseases that primarily affect women. She received a Ph.D. in Genetics from Harvard University in 1995. Currently she works in the Center for Genetic Epidemiology at the University of Southern California and Materna Biosciences, Inc. She has published peer-reviewed scientific articles on ovarian cancer, breast cancer, multiple sclerosis, and discovered the first genes associated with uterine fibroids, nausea and vomiting of pregnancy, and hyperemesis gravidarum. She is a science advisor and board member for the Hyperemesis Education and Research Foundation.
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