Faculty

Eunjung Lee

Eunjung Lee

Associate Professor of Clinical Population and Public Health Sciences
Medicine
NOR 4449A 1441 Eastlake Avenue Health Sciences Campus Los Angeles

A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders Nat Commun. 2024 Sep 27; 15(1):8268. . View in PubMed

Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication Nat Commun. 2024 Sep 02; 15(1):7640. . View in PubMed

Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants medRxiv. 2024 Jul 22. . View in PubMed

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia bioRxiv. 2024 Jan 04. . View in PubMed

Impaired neural stress resistance and loss of REST in bipolar disorder Mol Psychiatry. 2024 01; 29(1):153-164. . View in PubMed

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia Cell Rep. 2024 01 23; 43(1):113622. . View in PubMed

Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations bioRxiv. 2023 Dec 01. . View in PubMed

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs bioRxiv. 2023 Oct 19. . View in PubMed

Characterizing the molecular impact of KMT2D variants on the epigenetic and transcriptional landscapes in Kabuki syndrome Hum Mol Genet. 2023 06 19; 32(13):2251-2261. . View in PubMed

Contribution and therapeutic implications of retroelement insertions in ataxia telangiectasia Am J Hum Genet. 2023 11 02; 110(11):1976-1982. . View in PubMed

Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy JAMA Neurol. 2023 06 01; 80(6):578-587. . View in PubMed

An Approach to the Primary and Secondary Prevention of Gastric Cancer in the United StatesClin Gastroenterol Hepatol. 2022 10; 20(10):2218-2228. e2. . View in PubMed

Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity Nat Aging. 2022 08; 2(8):714-725. . View in PubMed

Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain Cancer Discov. 2022 01; 12(1):172-185. . View in PubMed

Endoscopy screening in high-risk populations as a strategy to improve early detection of gastric cancer in the United States Journal of Asian Health. 2022; 9:e202201. . View in PubMed

Bariatric surgery in patients with breast and endometrial cancer in California: population-based prevalence and survival Surg Obes Relat Dis. 2022 Jan; 18(1):42-52. . View in PubMed

Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study Drugs Aging. 2021 09; 38(9):817-828. . View in PubMed

Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk J Natl Cancer Inst. 2021 03 01; 113(3):329-337. . View in PubMed

Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data Front Aging. 2021; 2:800380. . View in PubMed

Immigration history, lifestyle characteristics, and breast density in the Vietnamese American Women's Health Study: a cross-sectional analysis Cancer Causes Control. 2020 Feb; 31(2):127-138. . View in PubMed

A Summary of the 2020 Gastric Cancer Summit at Stanford University Gastroenterology. 2020 10; 159(4):1221-1226. . View in PubMed

Hypertension, antihypertensive medications use and risk of age-related macular degeneration in California Teachers Cohort J Hum Hypertens. 2020 09; 34(8):568-576. . View in PubMed

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes Nat Genet. 2020 01; 52(1):56-73. . View in PubMed

Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women Int J Environ Res Public Health. 2020 01 17; 17(2). . View in PubMed

Parallel RNA and DNA analysis after deep sequencing (PRDD-seq) reveals cell type-specific lineage patterns in human brain Proc Natl Acad Sci U S A. 2020 06 23; 117(25):13886-13895. . View in PubMed

Genome-wide association study of germline variants and breast cancer-specific mortality Br J Cancer. 2019 03; 120(6):647-657. . View in PubMed

Evaluation of Medicare Claims Data as a Tool to Identify Dementia J Alzheimers Dis. 2019; 67(2):769-778. . View in PubMed

Shared heritability and functional enrichment across six solid cancers Nat Commun. 2019 01 25; 10(1):431. . View in PubMed

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes Am J Hum Genet. 2019 01 03; 104(1):21-34. . View in PubMed

Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study BMC Cancer. 2018 Nov 06; 18(1):1072. . View in PubMed

Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis Breast Cancer Res. 2018 01 22; 20(1):5. . View in PubMed

A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer Cancer Prev Res (Phila). 2017 Dec; 10(12):710-718. . View in PubMed

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer Nat Genet. 2017 Dec; 49(12):1767-1778. . View in PubMed

Stomach Cancer Disparity among Korean Americans by Tumor Characteristics: Comparison with Non-Hispanic Whites, Japanese Americans, South Koreans, and Japanese Cancer Epidemiol Biomarkers Prev. 2017 04; 26(4):587-596. . View in PubMed

Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis Breast Cancer Res. 2017 01 13; 19(1):6. . View in PubMed

Association analysis identifies 65 new breast cancer risk loci Nature. 2017 11 02; 551(7678):92-94. . View in PubMed

Body size over the life-course and the risk of endometrial cancer: the California Teachers Study Cancer Causes Control. 2016 Dec; 27(12):1419-1428. . View in PubMed

Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry Cancer Causes Control. 2016 May; 27(5):679-93. . View in PubMed

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 Nat Genet. 2016 Apr; 48(4):374-86. . View in PubMed

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers J Natl Cancer Inst. 2016 Feb; 108(2). . View in PubMed

Disparities in colorectal cancer incidence among Latino subpopulations in California defined by country of origin Cancer Causes Control. 2016 Feb; 27(2):147-55. . View in PubMed

International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries Cancer Epidemiol. 2016 Feb; 40:141-51. . View in PubMed

Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study BMC Cancer. 2016 Jan 12; 16:14. . View in PubMed

Traditional Breast Cancer Risk Factors in Filipina Americans Compared with Chinese and Japanese Americans in Los Angeles County Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1572-1586. . View in PubMed

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer Nat Commun. 2016 04 27; 7:11375. . View in PubMed

Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study Breast Cancer Res. 2016 06 17; 18(1):62. . View in PubMed

Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1801-3. . View in PubMed

Indicators of microbial-rich environments and the development of papillary thyroid cancer in the California Teachers Study Cancer Epidemiol. 2015 Aug; 39(4):548-53. . View in PubMed

Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2) Cancer Causes Control. 2015 Feb; 26(2):287-296. . View in PubMed

Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study Breast Cancer Res. 2014 Dec 11; 16(6):477. . View in PubMed

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade Hum Mol Genet. 2014 Nov 15; 23(22):6034-46. . View in PubMed

Estimating risks for variants of unknown significance according to their predicted pathogenicity classes with application to BRCA1 Breast Cancer Res Treat. 2014 Feb; 144(1):171-7. . View in PubMed

Reproductive factors, exogenous hormones, and pancreatic cancer risk in the CTS Am J Epidemiol. 2013 Nov 01; 178(9):1403-13. . View in PubMed

Hormone metabolism genes and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6. . View in PubMed

Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women Cancer Res. 2013 Mar 15; 73(6):1876-82. . View in PubMed

Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55 PLoS One. 2013; 8(6):e65313. . View in PubMed

Soy isoflavones and breast cancer Am Soc Clin Oncol Educ Book. 2013; 102-6. . View in PubMed

Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk Cancer Epidemiol Biomarkers Prev. 2012 Jul; 21(7):1156-66. . View in PubMed

Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):635-44. . View in PubMed

Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer Int J Cancer. 2012 Apr 01; 130(7):1629-38. . View in PubMed

Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation: results from a population-based study of young women J Clin Oncol. 2011 Nov 20; 29(33):4373-80. . View in PubMed

The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort Breast Cancer Res. 2011 Apr 01; 13(2):R37. . View in PubMed

GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy Int J Cancer. 2011 Feb 01; 128(3):726-31. . View in PubMed

Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study Cancer Epidemiol Biomarkers Prev. 2010 Sep; 19(9):2366-78. . View in PubMed

Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach Carcinogenesis. 2010 Aug; 31(8):1392-9. . View in PubMed

Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based study Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3170-8. . View in PubMed

The role of established breast cancer susceptibility loci in mammographic density in young women Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):258-60. . View in PubMed

Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients Breast Cancer Res. 2008; 10(1):R19. . View in PubMed

GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer Cancer Res. 2006 Aug 15; 66(16):7849-53. . View in PubMed

Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha Mol Pharmacol. 2001 May; 59(5):1216-24. . View in PubMed

My primary research interests are in understanding the environmental and lifestyle factors that influence cancer risk and cancer disparities with focus on understudied Asian American and Latinx populations.
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