Faculty

Daniel Oscar Stram

Daniel Oscar Stram

Professor of Population and Public Health Sciences
Medicine
SSB 202D 2001 N. Soto Street Health Sciences Campus Los Angeles

Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study J Clin Oncol. 2024 Oct 08; JCO2400418. . View in PubMed

Association of Urinary Biomarkers of Tobacco Exposure with Lung Cancer Risk in African American and White Cigarette Smokers in the Southern Community Cohort Study Cancer Epidemiol Biomarkers Prev. 2024 Aug 01; 33(8):1073-1082. . View in PubMed

Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort Int J Hyg Environ Health. 2024 Jun; 259:114362. . View in PubMed

Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study Cancer Epidemiol Biomarkers Prev. 2024 May 01; 33(5):703-711. . View in PubMed

Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia Hum Mol Genet. 2024 Apr 08; 33(8):687-697. . View in PubMed

Excess pancreatic cancer risk due to smoking and modifying effect of quitting smoking: The Multiethnic Cohort Study Cancer Causes Control. 2024 Mar; 35(3):541-548. . View in PubMed

Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts Am J Hum Genet. 2024 03 07; 111(3):456-472. . View in PubMed

Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers Chem Res Toxicol. 2024 02 19; 37(2):374-384. . View in PubMed

Association of Endocrine Disrupting Chemicals With the Metabolic Syndrome Among Women in the Multiethnic Cohort Study J Endocr Soc. 2023 Nov 02; 7(12):bvad136. . View in PubMed

Second Primary Lung Cancer Among Lung Cancer Survivors Who Never Smoked JAMA Netw Open. 2023 Nov 01; 6(11):e2343278. . View in PubMed

Particulate matter, traffic-related air pollutants, and circulating C-reactive protein levels: The Multiethnic Cohort Study Environ Pollut. 2023 Sep 01; 332:121962. . View in PubMed

Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study J Gerontol A Biol Sci Med Sci. 2023 Jul 08; 78(7):1246-1257. . View in PubMed

Diet Quality and Pancreatic Cancer Incidence in the Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2023 01 09; 32(1):123-131. . View in PubMed

Association of Urinary Biomarkers of Smoking-Related Toxicants with Lung Cancer Incidence in Smokers: The Multiethnic Cohort Study Cancer Epidemiol Biomarkers Prev. 2023 03 06; 32(3):306-314. . View in PubMed

Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study PLoS One. 2023; 18(1):e0279932. . View in PubMed

Prognostic utility of self-reported sarcopenia (SARC-F) in the Multiethnic Cohort J Cachexia Sarcopenia Muscle. 2022 04; 13(2):987-1002. . View in PubMed

Outdoor ambient air pollution and breast cancer survival among California participants of the Multiethnic Cohort Study Environ Int. 2022 03; 161:107088. . View in PubMed

Traffic-related Air Pollution and Lung Cancer Incidence: The California Multiethnic Cohort Study Am J Respir Crit Care Med. 2022 10 15; 206(8):1008-1018. . View in PubMed

Quantitation of DNA Adducts Resulting from Acrolein Exposure and Lipid Peroxidation in Oral Cells of Cigarette Smokers from Three Racial/Ethnic Groups with Differing Risks for Lung Cancer Chem Res Toxicol. 2022 10 17; 35(10):1914-1922. . View in PubMed

Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits Am J Hum Genet. 2022 04 07; 109(4):669-679. . View in PubMed

Dosimetry and uncertainty approaches for the million person study of low-dose radiation health effects: overview of the recommendations in NCRP Report No178. Int J Radiat Biol. 2022; 98(4):600-609. . View in PubMed

Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation EClinicalMedicine. 2021 Oct; 40:101093. . View in PubMed

Hum Genet. 2021 Oct; 140(10):1449-1457. . View in PubMed

Genetic discovery and risk characterization in type 2 diabetes across diverse populations HGG Adv. 2021 Apr 08; 2(2). . View in PubMed

The association between ambient air pollutants and pancreatic cancer in the Multiethnic Cohort Study Environ Res. 2021 11; 202:111608. . View in PubMed

Racial/ethnic disparities in weight or BMI change in adulthood and pancreatic cancer incidence: The multiethnic cohort Cancer Med. 2021 06; 10(12):4097-4106. . View in PubMed

Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium Cancer Epidemiol Biomarkers Prev. 2021 04; 30(4):623-642. . View in PubMed

Ethnic Differences of Urinary Cadmium in Cigarette Smokers from the Multiethnic Cohort Study Int J Environ Res Public Health. 2021 03 06; 18(5). . View in PubMed

Letter to the Editor Concerning Stram et al: "Lung Cancer in the Mayak Workers Cohort: Risk Estimation and Uncertainty Analysis. " Radiat Res 2021; 195:334-46. Radiat Res. 2021 10 01; 196(4):449-451. . View in PubMed

Multiethnic Prediction of Nicotine Biomarkers and Association With Nicotine Dependence Nicotine Tob Res. 2021 11 05; 23(12):2162-2169. . View in PubMed

Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study Cancer Res. 2021 08 15; 81(16):4360-4369. . View in PubMed

Lung Cancer in the Mayak Workers Cohort: Risk Estimation and Uncertainty Analysis Radiat Res. 2021 04 01; 195(4):334-346. . View in PubMed

Ethnic differences in excretion of butadiene-DNA adducts by current smokers Carcinogenesis. 2021 05 28; 42(5):694-704. . View in PubMed

Associations of the gut microbiome with hepatic adiposity in the Multiethnic Cohort Adiposity Phenotype Study Gut Microbes. 2021 Jan-Dec; 13(1):1965463. . View in PubMed

Risk of breast cancer and prediagnostic urinary excretion of bisphenol A, triclosan and parabens: The Multiethnic Cohort Study Int J Cancer. 2021 10 01; 149(7):1426-1434. . View in PubMed

Genome-wide association study of pancreatic fat: The Multiethnic Cohort Adiposity Phenotype Study PLoS One. 2021; 16(7):e0249615. . View in PubMed

Genome-Wide Association Analyses Identify Variants in IRF4 Associated With Acute Myeloid Leukemia and Myelodysplastic Syndrome Susceptibility Front Genet. 2021; 12:554948. . View in PubMed

Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study Breast Cancer Res. 2021 04 06; 23(1):44. . View in PubMed

A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study Breast. 2020 Dec; 54:62-69. . View in PubMed

Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study Hepatol Commun. 2020 Aug; 4(8):1112-1123. . View in PubMed

Exposure Measurement Error in Air Pollution Studies: The Impact of Shared, Multiplicative Measurement Error on Epidemiological Health Risk Estimates Air Qual Atmos Health. 2020 Jun; 13(6):631-643. . View in PubMed

Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study JNCI Cancer Spectr. 2020 Apr; 4(2):pkz107. . View in PubMed

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci Mol Psychiatry. 2020 10; 25(10):2392-2409. . View in PubMed

Variability in Cytogenetic Testing for Multiple Myeloma: A Comprehensive Analysis From Across the United States JCO Oncol Pract. 2020 10; 16(10):e1169-e1180. . View in PubMed

Estrogen Plus Progestin Hormone Therapy and Ovarian Cancer: A Complicated Relationship Explored Epidemiology. 2020 05; 31(3):402-408. . View in PubMed

Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study PLoS Genet. 2020 03; 16(3):e1008684. . View in PubMed

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women Nat Commun. 2020 07 31; 11(1):3833. . View in PubMed

Radiation Treatment, ATM, BRCA1/2, and CHEK2*1100delC Pathogenic Variants and Risk of Contralateral Breast Cancer J Natl Cancer Inst. 2020 12 14; 112(12):1275-1279. . View in PubMed

A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry Blood Adv. 2020 01 14; 4(1):181-190. . View in PubMed

Association between ambient air pollution and breast cancer risk: The multiethnic cohort study Int J Cancer. 2020 02 01; 146(3):699-711. . View in PubMed

Issues in Interpreting Epidemiologic Studies of Populations Exposed to Low-Dose, High-Energy Photon Radiation J Natl Cancer Inst Monogr. 2020 07 01; 2020(56):176-187. . View in PubMed

Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Summary Bias Assessment and Meta-Analysis J Natl Cancer Inst Monogr. 2020 07 01; 2020(56):188-200. . View in PubMed

Urinary N7-(1-hydroxy-3-buten-2-yl) guanine adducts in humans: temporal stability and association with smoking Mutagenesis. 2020 02 13; 35(1):19-26. . View in PubMed

Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort Cancer Med. 2019 07; 8(7):3592-3603. . View in PubMed

Genetic analyses of diverse populations improves discovery for complex traits Nature. 2019 06; 570(7762):514-518. . View in PubMed

Exposure measurement error in air pollution studies: A framework for assessing shared, multiplicative measurement error in ensemble learning estimates of nitrogen oxides Environ Int. 2019 04; 125:97-106. . View in PubMed

Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic GroupsGastroenterology. 2019 03; 156(4):966-975. e10. . View in PubMed

Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update J Natl Cancer Inst. 2019 08 01; 111(8):811-819. . View in PubMed

Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer JAMA Netw Open. 2019 09 04; 2(9):e1912259. . View in PubMed

Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort J Natl Cancer Inst. 2019 01 01; 111(1):27-33. . View in PubMed

Association between mitochondrial genetic variation and breast cancer risk: The Multiethnic Cohort PLoS One. 2019; 14(10):e0222284. . View in PubMed

Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study BMC Cancer. 2018 Nov 06; 18(1):1072. . View in PubMed

Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI Int J Obes (Lond). 2018 03; 42(3):384-390. . View in PubMed

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci Pharmacogenet Genomics. 2018 02; 28(2):49-55. . View in PubMed

Evaluation of 71 Coronary Artery Disease Risk Variants in a Multiethnic Cohort Front Cardiovasc Med. 2018; 5:19. . View in PubMed

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation Nat Commun. 2018 04 10; 9:16193. . View in PubMed

Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation Blood. 2018 05 31; 131(22):2490-2499. . View in PubMed

Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations Clin Epigenetics. 2018 08 23; 10(1):110. . View in PubMed

Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers NPJ Precis Oncol. 2018; 2:17. . View in PubMed

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2018 05 20; 36(15):1513-1520. . View in PubMed

Sex and ethnic/racial-specific risk factors for gallbladder disease BMC Gastroenterol. 2017 Dec 08; 17(1):153. . View in PubMed

Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex Blood Adv. 2017 Sep 12; 1(20):1717-1728. . View in PubMed

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis PLoS Med. 2017 Sep; 14(9):e1002383. . View in PubMed

Estimates of Radiation Effects on Cancer Risks in the Mayak Worker, Techa River and Atomic Bomb Survivor Studies Radiat Prot Dosimetry. 2017 Apr 01; 173(1-3):26-31. . View in PubMed

THE GROWTH OF BIOSTATISTICS AND ESTIMATION OF CANCER RISK ESTIMATES: PAST, CURRENT, AND FUTURE CHALLENGES Radiat Prot Dosimetry. 2017 Apr 01; 173(1-3):32-35. . View in PubMed

Coffee Drinking and Alcoholic and Nonalcoholic Fatty Liver Diseases and Viral Hepatitis in the Multiethnic Cohort Clin Gastroenterol Hepatol. 2017 08; 15(8):1305-1307. . View in PubMed

Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1034-1042. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. . View in PubMed

Mortality from solid cancers other than lung, liver, and bone in relation to external dose among plutonium and non-plutonium workers in the Mayak Worker Cohort Radiat Environ Biophys. 2017 03; 56(1):121-125. . View in PubMed

Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant Blood. 2017 09 28; 130(13):1585-1596. . View in PubMed

Correction of confidence intervals in excess relative risk models using Monte Carlo dosimetry systems with shared errors PLoS One. 2017; 12(4):e0174641. . View in PubMed

Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study PLoS One. 2017; 12(5):e0178435. . View in PubMed

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer Cancer Res. 2017 06 01; 77(11):2789-2799. . View in PubMed

Multi-SNP Haplotype Analysis Methods for Association Analysis Methods Mol Biol. 2017; 1666:485-504. . View in PubMed

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry J Natl Cancer Inst. 2017 08 01; 109(8). . View in PubMed

Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans Int J Cancer. 2017 06 15; 140(12):2728-2733. . View in PubMed

Association analysis identifies 65 new breast cancer risk loci Nature. 2017 11 02; 551(7678):92-94. . View in PubMed

Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study J Natl Cancer Inst. 2017 10 01; 109(10). . View in PubMed

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer Int J Cancer. 2016 Dec 15; 139(12):2646-2654. . View in PubMed

Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States JAMA Oncol. 2016 Oct 01; 2(10):1295-1302. . View in PubMed

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24 J Natl Cancer Inst. 2016 Jul; 108(7). . View in PubMed

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation Nat Commun. 2016 Apr 07; 7:10979. . View in PubMed

Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity Carcinogenesis. 2016 Mar; 37(3):269-279. . View in PubMed

Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk Hum Mol Genet. 2016 Jan 15; 25(2):371-81. . View in PubMed

Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: The multiethnic cohort Hepatology. 2016 12; 64(6):1969-1977. . View in PubMed

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. . View in PubMed

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Cancer Discov. 2016 09; 6(9):1052-67. . View in PubMed

No Association between the Mitochondrial Genome and Prostate Cancer Risk: The Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2016 06; 25(6):1001-3. . View in PubMed

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk Obstet Gynecol. 2016 05; 127(5):828-836. . View in PubMed

Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer PLoS One. 2016; 11(6):e0156203. . View in PubMed

Meta-Analysis of Rare Variant Association Tests in Multiethnic Populations Genet Epidemiol. 2016 Jan; 40(1):57-65. . View in PubMed

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) Sci Rep. 2016 09 07; 6:32512. . View in PubMed

Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort PLoS One. 2016; 11(3):e0150641. . View in PubMed

Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer Nat Genet. 2016 Jan; 48(1):101. . View in PubMed

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer Res. 2016 10 01; 76(19):5768-5776. . View in PubMed

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium Clin Cancer Res. 2015 Dec 01; 21(23):5264-76. . View in PubMed

Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study Am J Epidemiol. 2015 Dec 01; 182(11):945-51. . View in PubMed

ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3) Prostate. 2015 Nov; 75(15):1677-81. . View in PubMed

Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1801-3. . View in PubMed

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions Hum Mol Genet. 2015 Oct 01; 24(19):5603-18. . View in PubMed

Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort Study Am J Epidemiol. 2015 Jun 01; 181(11):889-97. . View in PubMed

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q312. Hum Mol Genet. 2015 May 15; 24(10):2966-84. . View in PubMed

Population distribution of lifetime risk of ovarian cancer in the United States Cancer Epidemiol Biomarkers Prev. 2015 Apr; 24(4):671-676. . View in PubMed

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer Nat Genet. 2015 Apr; 47(4):373-80. . View in PubMed

Generalizability of established prostate cancer risk variants in men of African ancestry Int J Cancer. 2015 Mar 01; 136(5):1210-7. . View in PubMed

Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3) Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):627-30. . View in PubMed

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study Gynecol Oncol. 2015 Mar; 136(3):542-8. . View in PubMed

Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):561-9. . View in PubMed

Dose reconstruction for the million worker study: status and guidelines Health Phys. 2015 Feb; 108(2):206-20. . View in PubMed

Fine-scale mapping of the 5q112 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Am J Hum Genet. 2015 Jan 08; 96(1):5-20. . View in PubMed

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation Nat Genet. 2015 11; 47(11):1282-1293. . View in PubMed

Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults PLoS One. 2015; 10(6):e0131106. . View in PubMed

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk Hum Mol Genet. 2015 Jan 01; 24(1):285-98. . View in PubMed

Shared dosimetry error in epidemiological dose-response analyses PLoS One. 2015; 10(3):e0119418. . View in PubMed

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):119-27. . View in PubMed

Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort PLoS One. 2015; 10(9):e0136796. . View in PubMed

Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer PLoS One. 2015; 10(6):e0124841. . View in PubMed

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p1533. Hum Mol Genet. 2014 Dec 15; 23(24):6616-33. . View in PubMed

Diabetes and racial/ethnic differences in hepatocellular carcinoma risk: the multiethnic cohort J Natl Cancer Inst. 2014 Dec; 106(12). . View in PubMed

High calorie intake is associated with worsening insulin resistance and ß-cell function in Hispanic women after gestational diabetes mellitus Diabetes Care. 2014 Dec; 37(12):3294-300. . View in PubMed

Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium Am J Epidemiol. 2014 Nov 15; 180(10):1018-27. . View in PubMed

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium Hum Mol Genet. 2014 Nov 15; 23(22):6096-111. . View in PubMed

Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups Carcinogenesis. 2014 Nov; 35(11):2526-33. . View in PubMed

A comprehensive examination of breast cancer risk loci in African American women Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. . View in PubMed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer Nat Genet. 2014 Oct; 46(10):1103-9. . View in PubMed

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation Nat Commun. 2014 Sep 23; 4:4999. . View in PubMed

Fine-mapping IGF1 and prostate cancer risk in African Americans: the multiethnic cohort study Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1928-32. . View in PubMed

The role of local ancestry adjustment in association studies using admixed populations Genet Epidemiol. 2014 Sep; 38(6):502-15. . View in PubMed

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A Nat Commun. 2014 Aug 08; 5:4613. . View in PubMed

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians Diabetes. 2014 Jul; 63(7):2551-62. . View in PubMed

Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival J Natl Cancer Inst. 2014 Jun; 106(6):dju085. . View in PubMed

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium Br J Cancer. 2014 Feb 18; 110(4):1088-100. . View in PubMed

Analysis of cancer risks in populations near nuclear facilities: Phase IA report by the National Academies Nuclear and Radiation Studies Board. Health Phys. 2014 Feb; 106(2):305-6. . View in PubMed

Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium PLoS One. 2014; 9(3):e89791. . View in PubMed

Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study PLoS One. 2014; 9(2):e87762. . View in PubMed

Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans Hum Mol Genet. 2013 Dec 15; 22(24):5048-55. . View in PubMed

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1 Am J Hum Genet. 2013 Dec 05; 93(6):1046-60. . View in PubMed

Dietary patterns and breast cancer risk in the California Teachers Study cohort Am J Clin Nutr. 2013 Dec; 98(6):1524-32. . View in PubMed

Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk Cancer Epidemiol Biomarkers Prev. 2013 Nov; 22(11):2094-101. . View in PubMed

Role of aldehydes in the toxic and mutagenic effects of nitrosamines Chem Res Toxicol. 2013 Oct 21; 26(10):1464-73. . View in PubMed

Late health effects of radiation exposure: new statistical, epidemiological, and biological approaches Int J Radiat Biol. 2013 Aug; 89(8):673-83. . View in PubMed

Workshop report on atomic bomb dosimetry-residual radiation exposure: recent research and suggestions for future studies Health Phys. 2013 Aug; 105(2):140-9. . View in PubMed

Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls Hum Mol Genet. 2013 Jun 15; 22(12):2539-50. . View in PubMed

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):880-90. . View in PubMed

Hormone metabolism genes and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6. . View in PubMed

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers Am J Hum Genet. 2013 Apr 04; 92(4):489-503. . View in PubMed

Genome-wide association studies identify four ER negative-specific breast cancer risk loci Nat Genet. 2013 Apr; 45(4):392-8398e1-2. . View in PubMed

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer Nat Genet. 2013 Apr; 45(4):371-84384e1-2. . View in PubMed

Large-scale genotyping identifies 41 new loci associated with breast cancer risk Nat Genet. 2013 Apr; 45(4):353-61361e1-2. . View in PubMed

Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women Cancer Res. 2013 Mar 15; 73(6):1876-82. . View in PubMed

Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population PLoS Genet. 2013 Mar; 9(3):e1003419. . View in PubMed

Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations J Natl Cancer Inst. 2013 Feb 06; 105(3):237-43. . View in PubMed

A genome-wide association study of breast cancer in women of African ancestry Hum Genet. 2013 Jan; 132(1):39-48. . View in PubMed

A genome-wide scan for breast cancer risk haplotypes among African American women PLoS One. 2013; 8(2):e57298. . View in PubMed

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Nat Commun. 2013; 4:1628. . View in PubMed

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. . View in PubMed

Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium Am J Epidemiol. 2012 Dec 15; 176(12):1121-9. . View in PubMed

Evaluating genetic risk for prostate cancer among Japanese and Latinos Cancer Epidemiol Biomarkers Prev. 2012 Nov; 21(11):2048-58. . View in PubMed

Genetic predisposition to radiation-related cancer and potential implications for risk assessment Ann ICRP. 2012 Oct-Dec; 41(3-4):108-16. . View in PubMed

Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies Int J Cancer. 2012 Sep 15; 131(6):E1038-43. . View in PubMed

Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status J Med Genet. 2012 Sep; 49(9):601-8. . View in PubMed

Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):635-44. . View in PubMed

Common genetic variants in prostate cancer risk prediction--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3) Cancer Epidemiol Biomarkers Prev. 2012 Mar; 21(3):437-44. . View in PubMed

Regression calibration when foods (measured with error) are the variables of interest: markedly non-Gaussian data with many zeroes Am J Epidemiol. 2012 Feb 15; 175(4):325-31. . View in PubMed

Population genetic structure and origins of Native Hawaiians in the multiethnic cohort study PLoS One. 2012; 7(11):e47881. . View in PubMed

Multi-SNP haplotype analysis methods for association analysis Methods Mol Biol. 2012; 850:423-52. . View in PubMed

Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies Gut. 2011 Dec; 60(12):1703-11. . View in PubMed

Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans Hum Mol Genet. 2011 Nov 15; 20(22):4491-503. . View in PubMed

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer Nat Genet. 2011 Oct 30; 43(12):1210-4. . View in PubMed

Genome-wide association study identifies new prostate cancer susceptibility loci Hum Mol Genet. 2011 Oct 01; 20(19):3867-75. . View in PubMed

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Use of generalized estimating equations in segregation analysis of continuous outcomes Genet Epidemiol. 1993; 10(6):575-9. . View in PubMed

An estimate of the magnitude of random errors in the DS86 dosimetry from data on chromosome aberrations and severe epilation Radiat Res. 1991 Nov; 128(2):157-69. . View in PubMed

Aggressive surgery combined with intensive chemotherapy improves survival in poor-risk neuroblastoma J Pediatr Surg. 1991 Sep; 26(9):1119-23; discussion 1123-4. . View in PubMed

Allowing for dose-estimation errors for the A-bomb survivor data J Radiat Res. 1991 Mar; 32 Suppl:108-21. . View in PubMed

Recent uses of biological data for the evaluation of A-bomb radiation dosimetry J Radiat Res. 1991 Mar; 32 Suppl:122-35. . View in PubMed

The observed relationship between the occurrence of acute radiation effects and leukemia mortality among A-bomb survivors Radiat Res. 1991 Feb; 125(2):206-13. . View in PubMed

Allowing for random errors in radiation dose estimates for the atomic bomb survivor data Radiat Res. 1990 Sep; 123(3):275-84. . View in PubMed

Smoking and serum proteins in atomic-bomb survivors in Japan Am J Epidemiol. 1990 Jun; 131(6):1038-45. . View in PubMed

Effects of inhalable particles on respiratory health of children Am Rev Respir Dis. 1989 Mar; 139(3):587-94. . View in PubMed

Analysis of the DS86 atomic bomb radiation dosimetry methods using data on severe epilation Radiat Res. 1989 Jan; 117(1):93-113. . View in PubMed

Analysing repeated measurements with possibly missing observations by modelling marginal distributions Stat Med. 1988 Jan-Feb; 7(1-2):139-48. . View in PubMed

My research is on general biostatistical issues in epidemiology, and I am a long time collaborator on a number of important prospective (cohort) studies of cancer and other diseases. These include the Atomic Bomb Survivors Study, the Multiethnic Cohort Study, and the Children's Health Study. I participate in many other projects in the Preventive Medicine Department at USC. I have particular interest in measurement error issues in dosimetry for radiation epidemiology and in dietary assessment for nutritional epidemiology. I have recently begun working on association-based testing for the influence upon cancer risk of genomic variation in candidate genes using nested case-control studies within the MEC, with special emphasis on haplotype-based risk estimation and haplotype-tagging SNP selection. See the publications and software development list below, for further information.
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