Faculty

Christopher Haiman

Christopher Haiman

Professor of Population and Public Health Sciences;AFLAC Chair in Cancer Research;Director, Center for Genetic Epidemiology;Division Chief, Epidemiology and Genetics
Genetic Epidemiology
NRT 1504 1450 Biggy St. Health Sciences Campus Los Angeles

0: a contralateral breast cancer risk prediction model developed and validated in? 200000 patients. Breast Cancer Res. 2022 Nov 22; 24(1):82.. View in PubMed

0: a contralateral breast cancer risk prediction model developed and validated in ~? 200000 patients. Breast Cancer Res. 2022 10 21; 24(1):69.. View in PubMed

Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations Epigenetics. 2024 Dec; 19(1):2333668. . View in PubMed

Pathogenic variants in cancer susceptibility genes predispose to Ductal Carcinoma In situ of the breast Clin Cancer Res. 2024 Nov 08. . View in PubMed

A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer Nat Commun. 2024 Nov 06; 15(1):9587. . View in PubMed

Association of Gene Variant Type and Location with Breast Cancer Risk in the General Population medRxiv. 2024 Oct 12. . View in PubMed

Risk factors for second primary breast cancer by laterality, age, and race and ethnicity J Natl Cancer Inst. 2024 Oct 11. . View in PubMed

Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study J Clin Oncol. 2024 Oct 08; JCO2400418. . View in PubMed

Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa Nat Genet. 2024 Oct 02. . View in PubMed

Hierarchical joint analysis of marginal summary statistics-Part II: High-dimensional instrumental analysis of omics data Genet Epidemiol. 2024 Oct; 48(7):291-309. . View in PubMed

Alcohol intake and endogenous sex hormones in women: Meta-analysis of cohort studies and Mendelian randomization Cancer. 2024 Oct 01; 130(19):3375-3386. . View in PubMed

Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations Diabetologia. 2024 Sep 30. . View in PubMed

Development of a breast cancer risk prediction model integrating monogenic, polygenic, and epidemiologic risk Cancer Epidemiol Biomarkers Prev. 2024 Sep 11. . View in PubMed

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification medRxiv. 2024 Sep 04. . View in PubMed

Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk Cancer Epidemiol Biomarkers Prev. 2024 Sep 03; 33(9):1229-1239. . View in PubMed

Racial and ethnic differences in second primary lung cancer risk among lung cancer survivors JNCI Cancer Spectr. 2024 Sep 02; 8(5). . View in PubMed

Reproductive Factors and Thyroid Cancer Risk: The Multiethnic Cohort Study J Womens Health (Larchmt). 2024 Sep; 33(9):1158-1165. . View in PubMed

Hierarchical joint analysis of marginal summary statistics-Part I: Multipopulation fine mapping and credible set construction Genet Epidemiol. 2024 Sep; 48(6):241-257. . View in PubMed

ANO7 African-ancestral genomic diversity and advanced prostate cancer Prostate Cancer Prostatic Dis. 2024 Sep; 27(3):558-565. . View in PubMed

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction medRxiv. 2024 Aug 20. . View in PubMed

Adaption and National Validation of a Tool for Predicting Mortality from Other Causes Among Men with Nonmetastatic Prostate Cancer Eur Urol Oncol. 2024 Aug; 7(4):923-932. . View in PubMed

Intake of Sugar and Food Sources of Sugar and Colorectal Cancer Risk in the Multiethnic Cohort Study J Nutr. 2024 Aug; 154(8):2481-2492. . View in PubMed

Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum Nat Genet. 2024 Aug; 56(8):1763-1764. . View in PubMed

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer Cancer Res. 2024 Aug 01; 84(15):2533-2548. . View in PubMed

On the informative value of community-based indoor radon values in relation to lung cancer Cancer Med. 2024 Aug; 13(16):e70126. . View in PubMed

Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer HGG Adv. 2024 Jul 18; 5(3):100315. . View in PubMed

The Association of Alcohol Outlet Density With Alcohol Intake: The Multiethnic Cohort J Stud Alcohol Drugs. 2024 Jul; 85(4):453-462. . View in PubMed

Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization Breast Cancer Res Treat. 2024 Jul; 206(2):295-305. . View in PubMed

Understanding the genetic complexity of puberty timing across the allele frequency spectrum Nat Genet. 2024 Jul; 56(7):1397-1411. . View in PubMed

Early Prostate Cancer Deaths Among Men With Higher vs Lower Genetic Risk JAMA Netw Open. 2024 Jul 01; 7(7):e2420034. . View in PubMed

Diet Quality and Risk of Bladder Cancer in the Multiethnic Cohort Study Nutrients. 2024 Jun 20; 16(12). . View in PubMed

Plant-based dietary patterns and mortality from all causes, cardiovascular disease, and cancer: The Multiethnic Cohort Study Clin Nutr. 2024 Jun; 43(6):1447-1453. . View in PubMed

Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes Nat Commun. 2024 May 02; 15(1):3718. . View in PubMed

Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity Br J Cancer. 2024 May; 130(8):1286-1294. . View in PubMed

Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction Nat Genet. 2024 May; 56(5):819-826. . View in PubMed

Dietary Fiber Intake and Risk of Advanced and Aggressive Forms of Prostate Cancer: A Pooled Analysis of 15 Prospective Cohort Studies J Acad Nutr Diet. 2024 Apr 16. . View in PubMed

MUSSEL: Enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups Cell Genom. 2024 Apr 10; 4(4):100539. . View in PubMed

Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia Hum Mol Genet. 2024 Apr 08; 33(8):687-697. . View in PubMed

Identification of Genes with Rare Loss of Function Variants Associated with Aggressive Prostate Cancer and Survival Eur Urol Oncol. 2024 Apr; 7(2):248-257. . View in PubMed

Thyroid Cancer Survival in the Multiethnic Cohort Study Int J Environ Res Public Health. 2024 Mar 10; 21(3). . View in PubMed

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology Nature. 2024 Mar; 627(8003):347-357. . View in PubMed

Combining magnetic resonance imaging with a multi-ancestry polygenic risk score to improve identification of clinically significant prostate cancer JNCI Cancer Spectr. 2024 Feb 29; 8(2). . View in PubMed

Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias Neurology. 2024 Feb 13; 102(3):e208116. . View in PubMed

Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction medRxiv. 2024 Feb 13. . View in PubMed

Increasing risk of hepatocellular carcinoma with successive generations in the United States among Mexican American adults: The Multiethnic Cohort Cancer. 2024 01; 130(2):267-275. . View in PubMed

Adiposity, Weight Change, and Urinary Melatonin Levels among Men in the Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2024 01 09; 33(1):136-142. . View in PubMed

Cluster effect for SNP-SNP interaction pairs for predicting complex traits Sci Rep. 2024 08 12; 14(1):18677. . View in PubMed

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions Am J Hum Genet. 2024 06 06; 111(6):1061-1083. . View in PubMed

Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts Am J Hum Genet. 2024 03 07; 111(3):456-472. . View in PubMed

Avocado and Guacamole Consumption and Colorectal Cancer Risk: The Multiethnic Cohort Study Nutr Cancer. 2024; 76(4):372-378. . View in PubMed

The accuracy of polygenic score models for anthropometric traits and Type II Diabetes in the Native Hawaiian Population medRxiv. 2023 Dec 28. . View in PubMed

Risk Model-Based Lung Cancer Screening and Racial and Ethnic Disparities in the US JAMA Oncol. 2023 Dec 01; 9(12):1640-1648. . View in PubMed

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants Nat Genet. 2023 Dec; 55(12):2065-2074. . View in PubMed

Association of Endocrine Disrupting Chemicals With the Metabolic Syndrome Among Women in the Multiethnic Cohort Study J Endocr Soc. 2023 Nov 02; 7(12):bvad136. . View in PubMed

No Association of Trichomonas vaginalis Seropositivity with Advanced Prostate Cancer Risk in the Multiethnic Cohort: A Nested Case-Control Study Cancers (Basel). 2023 Oct 28; 15(21). . View in PubMed

Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa Res Sq. 2023 Oct 12. . View in PubMed

Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes Leukemia. 2023 Oct; 37(10):2142. . View in PubMed

Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts Hum Genet. 2023 Oct; 142(10):1477-1489. . View in PubMed

MUSSEL: Enhanced Bayesian Polygenic Risk Prediction Leveraging Information across Multiple Ancestry Groups bioRxiv. 2023 Sep 21. . View in PubMed

Particulate matter, traffic-related air pollutants, and circulating C-reactive protein levels: The Multiethnic Cohort Study Environ Pollut. 2023 Sep 01; 332:121962. . View in PubMed

WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE medRxiv. 2023 Aug 22. . View in PubMed

Alcohol intake and endogenous sex hormones in women: meta-analysis of cohort studies and Mendelian randomization Res Sq. 2023 Aug 16. . View in PubMed

Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study J Gerontol A Biol Sci Med Sci. 2023 Jul 08; 78(7):1246-1257. . View in PubMed

Understanding the genetic complexity of puberty timing across the allele frequency spectrum medRxiv. 2023 Jun 20. . View in PubMed

Genetically adjusted PSA levels for prostate cancer screening Nat Med. 2023 Jun; 29(6):1412-1423. . View in PubMed

Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry medRxiv. 2023 May 15. . View in PubMed

Transcriptome-Wide Association Analysis Identifies Novel Candidate Susceptibility Genes for Prostate-Specific Antigen Levels in Men Without Prostate Cancer medRxiv. 2023 May 05. . View in PubMed

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics bioRxiv. 2023 Apr 18. . View in PubMed

Multi-ancestry genome-wide study in >25 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications. medRxiv. 2023 Mar 31. . View in PubMed

Biochemical activity induced by a germline variation in KLK3 (PSA) associates with cellular function and clinical outcome in prostate cancer Res Sq. 2023 Mar 28. . View in PubMed

Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Nat Genet. 2023 Mar; 55(3):519-520. . View in PubMed

Association of the CHEK2 c1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Res Sq. 2023 Feb 13. . View in PubMed

Whole exome sequencing and replication for breast cancer among Hispanic/Latino women identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer medRxiv. 2023 Jan 28. . View in PubMed

Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity medRxiv. 2023 Jan 19. . View in PubMed

Erratum: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium HGG Adv. 2023 Jan 12; 4(1):100149. . View in PubMed

Atopic allergic conditions and prostate cancer risk and survival in the Multiethnic Cohort study Br J Cancer. 2023 10; 129(6):974-981. . View in PubMed

Association of the CHEK2 c1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Cancer Med. 2023 08; 12(15):16142-16162. . View in PubMed

Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry Eur Urol. 2023 07; 84(1):13-21. . View in PubMed

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes Diabetologia. 2023 07; 66(7):1273-1288. . View in PubMed

Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights Eur Urol. 2023 07; 84(1):127-137. . View in PubMed

Associations of minor histocompatibility antigens with outcomes following allogeneic hematopoietic cell transplantation Am J Hematol. 2023 06; 98(6):940-950. . View in PubMed

Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study Cancer Res Commun. 2023 05; 3(5):755-762. . View in PubMed

Validation and Comparison of Nutrient Intakes from Two Dietary Questionnaires Developed for the Multiethnic Cohort StudyJ Acad Nutr Diet. 2023 04; 123(4):655-663. e1. . View in PubMed

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals Nat Genet. 2023 04; 55(4):549-558. . View in PubMed

A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer Eur Urol. 2023 04; 83(4):343-351. . View in PubMed

Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias Alzheimers Dement. 2023 02; 19(2):507-517. . View in PubMed

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Nat Genet. 2023 01; 55(1):89-99. . View in PubMed

Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study PLoS One. 2023; 18(1):e0279932. . View in PubMed

Association of Obesity and Type 2 Diabetes with Non-Hodgkin Lymphoma: The Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2023 10 02; 32(10):1348-1355. . View in PubMed

Germline Sequencing Analysis to Inform Clinical Gene Panel Testing for Aggressive Prostate Cancer JAMA Oncol. 2023 11 01; 9(11):1514-1524. . View in PubMed

A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants: application to BRCA1 and BRCA2 Hum Mutat. 2023; 2023. . View in PubMed

Polygenic Risk Score Modifies Prostate Cancer Risk of Pathogenic Variants in Men of African Ancestry Cancer Res Commun. 2023 12 14; 3(12):2544-2550. . View in PubMed

Change in the inflammatory potential of diet over 10 years and subsequent mortality: the Multiethnic Cohort Study Br J Nutr. 2023 01 14; 129(1):157-165. . View in PubMed

Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis Int J Epidemiol. 2023 02 08; 52(1):71-86. . View in PubMed

The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study Elife. 2023 06 27; 12. . View in PubMed

Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry Am J Hum Genet. 2023 07 06; 110(7):1200-1206. . View in PubMed

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics Am J Hum Genet. 2023 11 02; 110(11):1853-1862. . View in PubMed

White Rice Consumption and Risk of Colorectal Cancer Among Japanese Americans: The Multiethnic Cohort Study J Epidemiol. 2023 04 05; 33(4):170-176. . View in PubMed

Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men Hum Mol Genet. 2023 01 13; 32(3):489-495. . View in PubMed

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry Genome Med. 2023 01 26; 15(1):7. . View in PubMed

Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 J Clin Oncol. 2023 03 20; 41(9):1703-1713. . View in PubMed

RE: Polygenic risk of any, metastatic, and fatal prostate cancer in the Million Veteran Program J Natl Cancer Inst. 2023 03 09; 115(3):341-342. . View in PubMed

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations Nat Commun. 2023 10 02; 14(1):6147. . View in PubMed

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects Nat Commun. 2023 08 23; 14(1):4863. . View in PubMed

A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry Breast Cancer Res. 2023 08 09; 25(1):93. . View in PubMed

Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Cancer Epidemiol Biomarkers Prev. 2023 09 01; 32(9):1265-1269. . View in PubMed

ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk Clin Cancer Res. 2023 08 15; 29(16):3037-3050. . View in PubMed

Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C Cancer Res. 2023 08 01; 83(15):2557-2571. . View in PubMed

Shared graft-versus-leukemia minor histocompatibility antigens in DISCOVeRY-BMT Blood Adv. 2023 05 09; 7(9):1635-1649. . View in PubMed

Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing HGG Adv. 2023 01 12; 4(1):100159. . View in PubMed

Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study Br J Sports Med. 2022 Oct; 56(20):1157-1170. . View in PubMed

Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study Cancer Res. 2022 Sep 16; 82(18):3201-3208. . View in PubMed

Incorporating progesterone receptor expression into the PREDICT breast prognostic model Eur J Cancer. 2022 Sep; 173:178-193. . View in PubMed

Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk Eur J Hum Genet. 2022 May; 30(5):630-631. . View in PubMed

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium HGG Adv. 2022 Apr 14; 3(2):100099. . View in PubMed

Diet quality and all-cause and cancer-specific mortality in cancer survivors and non-cancer individuals: the Multiethnic Cohort Study Eur J Nutr. 2022 Mar; 61(2):925-933. . View in PubMed

Urinary 6-sulfatoxymelatonin Levels and Prostate Cancer Risk among Men in the Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2022 Mar 01; 31(3):688-691. . View in PubMed

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes Leukemia. 2022 12; 36(12):2835-2844. . View in PubMed

A saturated map of common genetic variants associated with human height Nature. 2022 10; 610(7933):704-712. . View in PubMed

Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care Eur Urol. 2022 10; 82(4):341-351. . View in PubMed

Genome-Wide Epistatic Interaction between DEF1B and APOL1 High-Risk Genotypes for Chronic Kidney Disease Clin J Am Soc Nephrol. 2022 10; 17(10):1522-1525. . View in PubMed

Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study Alzheimers Dement. 2022 09; 18(9):1625-1634. . View in PubMed

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations Nat Med. 2022 08; 28(8):1679-1692. . View in PubMed

Evaluating breast cancer predisposition genes in women of African ancestry Genet Med. 2022 07; 24(7):1468-1475. . View in PubMed

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Nat Genet. 2022 05; 54(5):560-572. . View in PubMed

A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry Eur Urol. 2022 05; 81(5):458-462. . View in PubMed

Modifiable Factors and Incident Gout Across Ethnicity Within a Large Multiethnic Cohort of Older Adults J Rheumatol. 2022 05; 49(5):504-512. . View in PubMed

Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score Prostate Cancer Prostatic Dis. 2022 04; 25(4):755-761. . View in PubMed

A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women Cancer Res Commun. 2022 04; 2(4):211-219. . View in PubMed

Prognostic utility of self-reported sarcopenia (SARC-F) in the Multiethnic Cohort J Cachexia Sarcopenia Muscle. 2022 04; 13(2):987-1002. . View in PubMed

Polygenic risk modeling for prediction of epithelial ovarian cancer risk Eur J Hum Genet. 2022 03; 30(3):349-362. . View in PubMed

Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study Diabetologia. 2022 03; 65(3):477-489. . View in PubMed

Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):404-412. . View in PubMed

Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia Int J Cancer. 2022 10 01; 151(7):1033-1046. . View in PubMed

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations Elife. 2022 07 08; 11. . View in PubMed

Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort J Natl Cancer Inst. 2022 07 11; 114(7):959-968. . View in PubMed

Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries Am J Hum Genet. 2022 05 05; 109(5):871-884. . View in PubMed

Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits Am J Hum Genet. 2022 04 07; 109(4):669-679. . View in PubMed

Joint Associations of Race, Ethnicity, and Socioeconomic Status With Mortality in the Multiethnic Cohort Study JAMA Netw Open. 2022 04 01; 5(4):e226370. . View in PubMed

Plant-based dietary patterns defined by a priori indices and colorectal cancer risk by sex and race/ethnicity: the Multiethnic Cohort Study BMC Med. 2022 11 29; 20(1):430. . View in PubMed

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci Breast Cancer Res. 2022 04 12; 24(1):27. . View in PubMed

Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women Sci Rep. 2022 04 13; 12(1):6199. . View in PubMed

Genomics and phenomics of body mass index reveals a complex disease network Nat Commun. 2022 12 29; 13(1):7973. . View in PubMed

Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer J Natl Cancer Inst. 2022 05 09; 114(5):771-774. . View in PubMed

Rare germline copy number variants (CNVs) and breast cancer risk Commun Biol. 2022 01 18; 5(1):65. . View in PubMed

Common variants in breast cancer risk loci predispose to distinct tumor subtypes Breast Cancer Res. 2022 01 04; 24(1):2. . View in PubMed

A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk Int J Cancer. 2022 01 01; 150(1):80-90. . View in PubMed

Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach Hum Mol Genet. 2022 09 10; 31(18):3133-3143. . View in PubMed

Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa Genome Biol. 2022 09 13; 23(1):194. . View in PubMed

Distinct Reproductive Risk Profiles for Intrinsic-Like Breast Cancer Subtypes: Pooled Analysis of Population-Based Studies J Natl Cancer Inst. 2022 12 08; 114(12):1706-1719. . View in PubMed

Association of Prostate-Specific Antigen Levels with Prostate Cancer Risk in a Multiethnic Population: Stability Over Time and Comparison with Polygenic Risk Score Cancer Epidemiol Biomarkers Prev. 2022 12 05; 31(12):2199-2207. . View in PubMed

Cholesterol lowering drug use and breast cancer survival: the Multiethnic Cohort Study Breast Cancer Res Treat. 2021 Nov; 190(1):165-173. . View in PubMed

Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation EClinicalMedicine. 2021 Oct; 40:101093. . View in PubMed

Hum Genet. 2021 Oct; 140(10):1449-1457. . View in PubMed

Race, ethnicity, community-level socioeconomic factors, and risk of COVID-19 in the United States and the United Kingdom EClinicalMedicine. 2021 Aug; 38:101029. . View in PubMed

Large-scale cross-cancer fine-mapping of the 5p1533 region reveals multiple independent signals. HGG Adv. 2021 Jul 08; 2(3):100041. . View in PubMed

Comparison of the Prevalence of Pathogenic Variants in Cancer Susceptibility Genes in Black Women and Non-Hispanic White Women With Breast Cancer in the United States JAMA Oncol. 2021 Jul 01; 7(7):1045-1050. . View in PubMed

Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies? Cancers (Basel). 2021 May 14; 13(10).. View in PubMed

Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers Nat Commun. 2021 May 14; 12(1):2986. . View in PubMed

Diet Quality and Risk of Lung Cancer in the Multiethnic Cohort Study Nutrients. 2021 May 12; 13(5). . View in PubMed

Genetic discovery and risk characterization in type 2 diabetes across diverse populations HGG Adv. 2021 Apr 08; 2(2). . View in PubMed

Techniques and Outcomes of MRI-TRUS Fusion Prostate Biopsy Curr Urol Rep. 2021 Mar 22; 22(4):27. . View in PubMed

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 Mar; 53(3):413. . View in PubMed

Alcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness J Clin Med. 2021 Feb 02; 10(3). . View in PubMed

Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer Cancer Commun (Lond). 2021 12; 41(12):1387-1397. . View in PubMed

Mendelian randomisation study of smoking exposure in relation to breast cancer risk Br J Cancer. 2021 10; 125(8):1135-1145. . View in PubMed

Association of Genetic Risk Score With NAFLD in An Ethnically Diverse Cohort Hepatol Commun. 2021 10; 5(10):1689-1703. . View in PubMed

Genetic insights into biological mechanisms governing human ovarian ageing Nature. 2021 08; 596(7872):393-397. . View in PubMed

Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk Eur Urol. 2021 08; 80(2):134-138. . View in PubMed

Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer Prostate Cancer Prostatic Dis. 2021 06; 24(2):532-541. . View in PubMed

Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large US. Consortium. Cancer Epidemiol Biomarkers Prev. 2021 06; 30(6):1279-1282. . View in PubMed

Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium Cancer Epidemiol Biomarkers Prev. 2021 04; 30(4):623-642. . View in PubMed

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers Br J Cancer. 2021 02; 124(4):842-854. . View in PubMed

The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians PLoS Genet. 2021 02; 17(2):e1009273. . View in PubMed

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 01; 53(1):65-75. . View in PubMed

Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study Breast Cancer Res. 2021 04 06; 23(1):44. . View in PubMed

Genetic variants in anti-Müllerian hormone-related genes and breast cancer risk: results from the AMBER consortium Breast Cancer Res Treat. 2021 Jan; 185(2):469-478. . View in PubMed

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers Nat Commun. 2021 02 17; 12(1):1078. . View in PubMed

Risk of Late-Onset Breast Cancer in Genetically Predisposed Women J Clin Oncol. 2021 11 01; 39(31):3430-3440. . View in PubMed

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score J Clin Oncol. 2021 08 10; 39(23):2564-2573. . View in PubMed

Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry J Natl Cancer Inst. 2021 09 04; 113(9):1168-1176. . View in PubMed

Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer J Natl Cancer Inst. 2021 05 04; 113(5):616-625. . View in PubMed

Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast J Clin Oncol. 2021 12 10; 39(35):3918-3926. . View in PubMed

Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis Sci Rep. 2021 10 05; 11(1):19787. . View in PubMed

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment Breast Cancer Res. 2021 08 18; 23(1):86. . View in PubMed

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Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use Biol Psychiatry. 2019 06 01; 85(11):946-955. . View in PubMed

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Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes Am J Hum Genet. 2019 01 03; 104(1):21-34. . View in PubMed

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Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts J Natl Cancer Inst. 2019 02 01; 111(2):158-169. . View in PubMed

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Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort BMC Genomics. 2018 Jul 09; 19(1):524. . View in PubMed

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Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1186-1194. . View in PubMed

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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2018 07; 50(7):928-936. . View in PubMed

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Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study Hum Mol Genet. 2018 08 15; 27(16):2940-2953. . View in PubMed

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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer Nat Genet. 2017 Dec; 49(12):1767-1778. . View in PubMed

PHIP - a novel candidate breast cancer susceptibility locus on 6q141. Oncotarget. 2017 Nov 28; 8(61):102769-102782. . View in PubMed

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Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study J Am Coll Nutr. 2017 Jul; 36(5):378-385. . View in PubMed

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes Nat Genet. 2017 Jul; 49(7):1126-1132. . View in PubMed

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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer Nat Genet. 2017 May; 49(5):680-691. . View in PubMed

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A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes Diabetes. 2017 11; 66(11):2903-2914. . View in PubMed

Quantifying the Genetic Correlation between Multiple Cancer Types Cancer Epidemiol Biomarkers Prev. 2017 09; 26(9):1427-1435. . View in PubMed

High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic CohortGastroenterology. 2017 08; 153(2):386-394. e2. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. . View in PubMed

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Type II Diabetes, Obesity, and Breast Cancer Risk: The Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2017 06; 26(6):854-861. . View in PubMed

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The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers Cancer Epidemiol Biomarkers Prev. 2017 01; 26(1):126-135. . View in PubMed

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Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer PLoS Genet. 2014 Feb; 10(2):e1004129. . View in PubMed

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Early, non-psychotic deviant behavior in schizophrenia: a possible endophenotypic marker for genetic studies Psychiatry Res. 2001 Mar 25; 101(2):101-13. . View in PubMed

A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk Int J Cancer. 2000 Jul 15; 87(2):204-10. . View in PubMed

Evidence of a schizotypy subtype in OCD J Psychiatr Res. 2000 Jan-Feb; 34(1):15-24. . View in PubMed

Polymorphic repeat in AIB1 does not alter breast cancer risk Breast Cancer Res. 2000; 2(5):378-85. . View in PubMed

Phenotypic characteristics of Obsessive-Compulsive Disorder ascertained in adulthood J Psychiatr Res. 1999 May-Jun; 33(3):265-73. . View in PubMed

The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer Cancer Res. 1999 Mar 01; 59(5):1015-20. . View in PubMed

Binge eating before the onset of dieting: a distinct subgroup of bulimia nervosa? Int J Eat Disord. 1999 Mar; 25(2):151-7.. View in PubMed

Glutathione S-transferase GSTM1 and GSTT1 polymorphisms and colorectal cancer risk: a prospective study Cancer Epidemiol Biomarkers Prev. 1998 Nov; 7(11):1001-5. . View in PubMed

Does fluoxetine augment the inpatient treatment of anorexia nervosa? Am J Psychiatry. 1998 Apr; 155(4):548-51.. View in PubMed

Christopher Haiman, ScD, is a professor of preventive medicine at the Keck School of Medicine of USC and AFLAC Chair in Cancer Research. He also leads the Cancer Epidemiology Program at USC Norris Comprehensive Cancer Center and the Epidemiology and Genetics division in the Department of Preventive Medicine. Dr. Haiman is a genetic epidemiologist whose research is focused on exploring racial and ethnic disparities in cancer risk, with the goal of developing approaches to reduce these disparities. He is co-principal investigator of the Multiethnic Cohort (MEC), a large prospective study of cancer in primarily non-European ancestry populations (n>215,000) that has been the foundation of his scientific investigation into the genetic risk of cancer, initially through genome-wide association studies (GWAS) and more recently in large-scale genomic consortia in minority populations that employ next-generation sequencing technology. In addition to these leadership and administrative research positions, he has vast experience in directing large consortia and is currently the scientific leader of the African Ancestry Prostate Cancer Consortium (AAPC). He has also served as a steering committee member for numerous NIH consortia, including the NCI GAME-ON Consortium, NHGRI Population Architecture Using Genomics and Epidemiology Consortium (PAGE), NHGRI Gene Environment Association Studies (GENEVA) Consortium and the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). He is also the principal investigator of the RESPOND African-American prostate cancer initiative. He has co-authored more than 450 peer-reviewed publications, with many in prominent journals, including Nature Genetics, The New England Journal of Medicine and Journal of the National Cancer Institute.
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