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Adam de Smith
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A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children Cell Genom. 2024 Mar 22; 100526. . View in PubMed
Backtracking to the future: unraveling the origins of childhood leukemia Leukemia. 2024 02; 38(2):416-419. . View in PubMed
Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men Hum Mol Genet. 2023 01 13; 32(3):489-495. . View in PubMed
Associations between early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children Int J Cancer. 2023 03 01; 152(5):845-853. . View in PubMed
Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study Cancer Res. 2022 Sep 16; 82(18):3201-3208. . View in PubMed
Variant to function mapping at single-cell resolution through network propagation bioRxiv. 2022 Jan 24. . View in PubMed
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice Nat Biotechnol. 2022 12; 40(12):1834-1844. . View in PubMed
Variant to function mapping at single-cell resolution through network propagation Nat Biotechnol. 2022 11; 40(11):1644-1653. . View in PubMed
Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children PLoS Genet. 2022 09; 18(9):e1010388. . View in PubMed
Accelerated epigenetic aging in newborns with Down syndrome Aging Cell. 2022 07; 21(7):e13652. . View in PubMed
Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure Biotechniques. 2022 04; 72(4):121-133. . View in PubMed
Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia Leukemia. 2022 03; 36(3):865-868. . View in PubMed
Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples Leukemia. 2022 01; 36(1):279-282. . View in PubMed
Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome Blood Adv. 2022 07 26; 6(14):4132-4136. . View in PubMed
Mitochondrial 1555 G>A variant as a potential risk factor for childhood glioblastoma Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac045. . View in PubMed
Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis Am J Hematol. 2022 06 01; 97(6):E198-E201. . View in PubMed
Periconceptional folate intake influences DNA methylation at birth based on dietary source in an analysis of pediatric acute lymphoblastic leukemia cases and controls Am J Clin Nutr. 2022 12 19; 116(6):1553-1564. . View in PubMed
Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children Haematologica. 2022 09 01; 107(9):2266-2270. . View in PubMed
Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL Blood Adv. 2022 06 28; 6(12):3756-3766. . View in PubMed
Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia Hum Mol Genet. 2022 10 28; 31(21):3741-3756. . View in PubMed
Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1517-1525. . View in PubMed
Cancer health disparities in racial/ethnic minorities in the United States Br J Cancer. 2021 01; 124(2):315-332. . View in PubMed
Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia Am J Hum Genet. 2021 10 07; 108(10):1823-1835. . View in PubMed
Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites Elife. 2021 06 22; 10. . View in PubMed
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system Clin Sci (Lond). 2021 04 30; 135(8):1053-1063. . View in PubMed
Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016 Am J Epidemiol. 2021 04 06; 190(4):519-527. . View in PubMed
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis Nat Commun. 2021 02 05; 12(1):821. . View in PubMed
Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population Bone. 2020 01; 130:115070. . View in PubMed
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma Acta Neuropathol Commun. 2020 10 28; 8(1):173. . View in PubMed
European genetic ancestry associated with risk of childhood ependymoma Neuro Oncol. 2020 11 26; 22(11):1637-1646. . View in PubMed
History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System Am J Epidemiol. 2020 10 01; 189(10):1076-1085. . View in PubMed
Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia Blood Adv. 2020 02 25; 4(4):672-675. . View in PubMed
Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089. . View in PubMed
Germline cancer predisposition variants and pediatric glioma: a population-based study in California Neuro Oncol. 2020 06 09; 22(6):864-874. . View in PubMed
Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome Leukemia. 2019 11; 33(11):2746-2751. . View in PubMed
Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology Haematologica. 2019 11; 104(11):e514-e516. . View in PubMed
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children Genes Chromosomes Cancer. 2019 10; 58(10):723-730. . View in PubMed
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome Blood. 2019 10 10; 134(15):1227-1237. . View in PubMed
Germline genetic landscape of pediatric central nervous system tumors Neuro Oncol. 2019 11 04; 21(11):1376-1388. . View in PubMed
Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1151-1158. . View in PubMed
A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology Haematologica. 2018 01; 103(1):e29-e31. . View in PubMed
Genetic determinants of childhood and adult height associated with osteosarcoma risk Cancer. 2018 09 15; 124(18):3742-3752. . View in PubMed
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q2421. Nat Commun. 2018 01 18; 9(1):286. . View in PubMed
Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers Environ Health. 2018 05 02; 17(1):43. . View in PubMed
BMI1 enhancer polymorphism underlies chromosome 10p1231 association with childhood acute lymphoblastic leukemia. Int J Cancer. 2018 12 01; 143(11):2647-2658. . View in PubMed
To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes Front Genet. 2018; 9:298. . View in PubMed
Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma J Neurooncol. 2017 Nov; 135(2):237-244. . View in PubMed
Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia Cancer Res. 2017 04 01; 77(7):1674-1683. . View in PubMed
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia Blood. 2017 03 23; 129(12):1680-1684. . View in PubMed
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia Oncotarget. 2016 Nov 08; 7(45):72733-72745. . View in PubMed
Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia Arch Med Res. 2016 11; 47(8):677-683. . View in PubMed
Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates Epigenetics. 2016 09; 11(9):664-673. . View in PubMed
Cortical Lewy bodies and Aß burden are associated with prevalence and timing of dementia in Lewy body diseases Neuropathol Appl Neurobiol. 2016 08; 42(5):436-50. . View in PubMed
Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1043-9. . View in PubMed
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers Carcinogenesis. 2016 06; 37(6):576-582. . View in PubMed
A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros Leukemia. 2016 05; 30(5):1194-7. . View in PubMed
A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution Cancer Res. 2015 Nov 15; 75(22):4884-94. . View in PubMed
PDGFRa demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium Nat Commun. 2015 May 18; 6:6930. . View in PubMed
Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. . View in PubMed
Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes Epigenetics. 2015; 10(12):1166-76. . View in PubMed
Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA PLoS One. 2015; 10(11):e0143343. . View in PubMed
PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia Int J Cancer. 2014 Sep 01; 135(5):1101-9. . View in PubMed
Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia Am J Hematol. 2014 Jul; 89(7):721-5. . View in PubMed
Imprinted expression of UBE3A in non-neuronal cells from a Prader-Willi syndrome patient with an atypical deletion Hum Mol Genet. 2014 May 01; 23(9):2364-73. . View in PubMed
The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia Blood. 2014 Apr 17; 123(16):2497-503. . View in PubMed
Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children Leukemia. 2013 Dec; 27(12):2416-9. . View in PubMed
GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL Blood. 2013 Nov 07; 122(19):3385-7. . View in PubMed
Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype Blood. 2013 Jun 06; 121(23):4808-9. . View in PubMed
Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity PLoS One. 2013; 8(3):e58048. . View in PubMed
A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network Nucleic Acids Res. 2012 Dec; 40(22):11339-51. . View in PubMed
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity Hum Mol Genet. 2012 Aug 15; 21(16):3727-38. . View in PubMed
Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry Clin Chem. 2011 Aug; 57(8):1188-95. . View in PubMed
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly Nat Biotechnol. 2011 Jul 24; 29(8):723-30. . View in PubMed
Chromosome 19p133 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. Am J Med Genet A. 2011 May; 155A(5):1192-5. . View in PubMed
Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants Ann Hum Genet. 2011 May; 75(3):383-97. . View in PubMed
Implications of copy number variation in people with chromosomal abnormalities: potential for greater variation in copy number state may contribute to variability of phenotype Hugo J. 2010 Dec; 4(1-4):1-9. . View in PubMed
cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs Nat Methods. 2010 Jul; 7(7):541-6. . View in PubMed
A new highly penetrant form of obesity due to deletions on chromosome 16p112. Nature. 2010 Feb 04; 463(7281):671-5. . View in PubMed
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism Hum Mol Genet. 2009 Sep 01; 18(17):3257-65. . View in PubMed
Small deletion variants have stable breakpoints commonly associated with alu elements PLoS One. 2008 Aug 29; 3(8):e3104. . View in PubMed
Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease Cytogenet Genome Res. 2008; 123(1-4):17-26. . View in PubMed
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases Hum Mol Genet. 2007 Dec 01; 16(23):2783-94. . View in PubMed
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity Nat Genet. 2007 Jun; 39(6):721-3. . View in PubMed