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Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy Br J Pharmacol. 2018 10; 175(19):3747-3757. . View in PubMed

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Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments PLoS Comput Biol. 2016 12; 12(12):e1005253. . View in PubMed

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Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy Sci Rep. 2015 Dec 11; 5:18017. . View in PubMed

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ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis J Hepatol. 2014 Nov; 61(5):1126-34. . View in PubMed

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Cell death and cell death responses in liver disease: mechanisms and clinical relevanceGastroenterology. 2014 Oct; 147(4):765-783. e4. . View in PubMed

Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injuryGastroenterology. 2014 Jul; 147(1):109-118. e5. . View in PubMed

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ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading J Hepatol. 2013 Oct; 59(4):805-13. . View in PubMed

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c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice J Biol Chem. 2011 Oct 07; 286(40):35071-8. . View in PubMed

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Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. . View in PubMed

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice Hepatology. 2011 Jul; 54(1):229-39. . View in PubMed

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Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1495-9. . View in PubMed

Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes Hepatology. 1995 Jan; 21(1):207-14. . View in PubMed

Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye Exp Eye Res. 1994 Oct; 59(4):487-96. . View in PubMed

Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver Mol Pharmacol. 1994 Sep; 46(3):578-85. . View in PubMed

Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes J Clin Invest. 1994 Jul; 94(1):193-201. . View in PubMed

Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. . View in PubMed

Role of BSP/bilirubin binding protein and bilitranslocase in glutathione uptake in rat basolateral liver plasma membrane vesicles Biochem Biophys Res Commun. 1994 Apr 29; 200(2):1079-85. . View in PubMed

Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics J Clin Invest. 1994 Apr; 93(4):1841-5. . View in PubMed

Distribution of 3 alpha-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: comparison with glutathione S-transferase subunits J Gastroenterol. 1994 Apr; 29(2):115-9. . View in PubMed

Bidirectional membrane transport of intact glutathione in Hep G2 cells Am J Physiol. 1993 Dec; 265(6 Pt 1):G1128-34. . View in PubMed

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Identification and purification of a human liver cytosolic tocopherol binding protein Protein Expr Purif. 1993 Oct; 4(5):382-9. . View in PubMed

Thiol-disulfide effects on hepatic glutathione transportStudies in cultured rat hepatocytes and perfused livers. J Clin Invest. 1993 Sep; 92(3):1188-97. . View in PubMed

Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles J Biol Chem. 1993 May 25; 268(15):10836-41. . View in PubMed

Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes J Biol Chem. 1993 Feb 05; 268(4):2324-8. . View in PubMed

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats Hepatology. 1992 Dec; 16(6):1423-7. . View in PubMed

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Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles J Biol Chem. 1992 Nov 05; 267(31):22256-64. . View in PubMed

Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the ratStudies in cultured hepatocytes and in vivo. J Clin Invest. 1992 Aug; 90(2):524-32. . View in PubMed

The relationship between biliary secretion of bilirubin and glutathione in the rat Gastroenterol Jpn. 1992 Jun; 27(3):369-73. . View in PubMed

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Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol J Lipid Res. 1992 Mar; 33(3):343-50. . View in PubMed

Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion Hepatology. 1992 Mar; 15(3):507-14. . View in PubMed

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats J Biol Chem. 1992 Jan 25; 267(3):1667-73. . View in PubMed

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Effect of phorone and allopurinol on ischemia-reperfusion injury in gastrointestinal mucosa of the rat Pharmacology. 1992; 44(6):334-43. . View in PubMed

Glutathione metabolism and its role in hepatotoxicity Pharmacol Ther. 1991 Dec; 52(3):287-305. . View in PubMed

Effect of indomethacin on the uptake, metabolism and excretion of 3-oxocholic acid: studies in isolated hepatocytes and perfused rat liver Biochim Biophys Acta. 1991 Jul 30; 1084(3):247-50. . View in PubMed

Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat J Clin Invest. 1991 Jul; 88(1):260-9. . View in PubMed

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed ratsTracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest. 1991 Feb; 87(2):397-405. . View in PubMed

The use of monochlorobimane to determine hepatic GSH levels and synthesis Anal Biochem. 1990 Nov 01; 190(2):212-9. . View in PubMed

Importance and regulation of hepatic glutathione Semin Liver Dis. 1990 Nov; 10(4):251-66. . View in PubMed

Hormonal regulation of glutathione efflux J Biol Chem. 1990 Sep 25; 265(27):16088-95. . View in PubMed

Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ Am J Physiol. 1990 Jun; 258(6 Pt 1):G967-73. . View in PubMed

Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat J Clin Invest. 1990 Jun; 85(6):2009-13. . View in PubMed

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Oxidation and reduction of bile acid precursors by rat hepatic 3 alpha-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin Biochim Biophys Acta. 1990 Apr 02; 1043(2):153-6. . View in PubMed

Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver J Biol Chem. 1990 Feb 05; 265(4):2132-6. . View in PubMed

The use of isolated perfused liver in studies of biological transport processes Methods Enzymol. 1990; 192:485-95. . View in PubMed

Effects of chronic ethanol feeding on rat hepatocytic glutathioneRelationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest. 1989 Apr; 83(4):1247-52. . View in PubMed

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Role of glutathione status in protection against ethanol-induced gastric lesions Pharmacology. 1989; 38(1):57-60. . View in PubMed

The role of cytoplasmic proteins in hepatic bile acid transport Annu Rev Physiol. 1989; 51:161-76. . View in PubMed

Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes Am J Physiol. 1988 Oct; 255(4 Pt 1):G403-8. . View in PubMed

Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubinKinetics, sidedness, and molecular forms. J Clin Invest. 1988 Aug; 82(2):608-16. . View in PubMed

Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases Biochim Biophys Acta. 1988 Apr 28; 954(1):37-43. . View in PubMed

Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids J Lipid Res. 1988 Mar; 29(3):279-86. . View in PubMed

Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver Biochem Pharmacol. 1987 Nov 15; 36(22):4015-7. . View in PubMed

Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenaseII. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):861-6. . View in PubMed

Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenaseI. Studies with the purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):852-60. . View in PubMed

Effect of chronic ethanol feeding on rat hepatocytic glutathioneCompartmentation, efflux, and response to incubation with ethanol. J Clin Invest. 1987 Jul; 80(1):57-62. . View in PubMed

A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army N Engl J Med. 1987 Apr 16; 316(16):965-70. . View in PubMed

Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver Biochem Biophys Res Commun. 1987 Feb 27; 143(1):377-82. . View in PubMed

3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosolIdentification, kinetics, and physiologic significance. J Clin Invest. 1987 Feb; 79(2):427-34. . View in PubMed

Subunit heterogeneity of cationic human hepatic glutathione S-transferases Pharmacology. 1987; 35(2):65-78. . View in PubMed

Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein Arch Biochem Biophys. 1986 Nov 15; 251(1):385-92. . View in PubMed

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Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes Am J Physiol. 1986 Sep; 251(3 Pt 1):G354-61. . View in PubMed

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Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids J Lipid Res. 1986 Jun; 27(6):652-7. . View in PubMed

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Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution Hepatology. 1986 May-Jun; 6(3):433-9. . View in PubMed

Kinetics of glutathione efflux from isolated rat hepatocytes Am J Physiol. 1986 Feb; 250(2 Pt 1):G236-43. . View in PubMed

Organic anion-binding by human hepatic GSH S-transferases Biochem Pharmacol. 1986 Jan 15; 35(2):354-6. . View in PubMed

Gamma-glutamylcysteine: a substrate for glutathione S-transferases Biochem Pharmacol. 1985 Oct 15; 34(20):3643-7. . View in PubMed

Modulating effect of thiol-disulfide status on [14C]aminopyrine accumulation in the isolated parietal cell J Biol Chem. 1985 Jul 05; 260(13):8020-5. . View in PubMed

Acetaldehyde-dependent oxidation of glutathione catalyzed by rat liver cytosol Biochem Biophys Res Commun. 1985 Jun 28; 129(3):949-57. . View in PubMed

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Sinusoidal efflux of glutathione in the perfused rat liverEvidence for a carrier-mediated process. J Clin Invest. 1985 Jan; 75(1):258-65. . View in PubMed

The regulation of hepatic glutathione Annu Rev Pharmacol Toxicol. 1985; 25:715-44. . View in PubMed

Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosol Biochem J. 1984 Dec 15; 224(3):947-53. . View in PubMed

Identification and purification of a 36 kDa bile acid binder in human hepatic cytosol FEBS Lett. 1984 Nov 05; 177(1):31-5. . View in PubMed

Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin J Lipid Res. 1984 Nov; 25(11):1177-83. . View in PubMed

Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin Biochem Pharmacol. 1984 Nov 01; 33(21):3511-3. . View in PubMed

Comparison of binding of thyroid hormone analogues to hepatic organic anion binding proteins Biochim Biophys Acta. 1984 Sep 28; 801(2):184-8. . View in PubMed

Role of glutathione in gastric mucosal cytoprotection Am J Physiol. 1984 Sep; 247(3 Pt 1):G296-304. . View in PubMed

Inhibition of glutathione efflux from isolated rat hepatocytes by methionine J Biol Chem. 1984 Aug 10; 259(15):9355-8. . View in PubMed

Quantitation and characterization of a newly described organic anion binder by radioimmunoassay Biochim Biophys Acta. 1984 Jul 30; 800(2):171-7. . View in PubMed

Binding of glutathione by rat liver cytosol Pharmacology. 1984; 28(2):61-6. . View in PubMed

Newly identified bile acid binders in rat liver cytosolPurification and comparison with glutathione S-transferases. J Biol Chem. 1983 Mar 25; 258(6):3602-7. . View in PubMed

Factors influencing the efflux of hepatic glutathione into bile in rats J Pharmacol Exp Ther. 1983 Jan; 224(1):141-7. . View in PubMed

Newly identified organic anion-binding proteins in rat liver cytosol Biochim Biophys Acta. 1982 Dec 20; 709(2):342-52. . View in PubMed

Propylthiouracil treatment for alcoholic hepatitis: should it and does it work? Gastroenterology. 1982 Jun; 82(6):1468-71.. View in PubMed

Identification of hepatic Z-protein in a marine elasmobranch, Platyrhinoides triseriata Biochem J. 1982 May 01; 203(2):377-81. . View in PubMed

Glutathione S-transferases in elasmobranch liverMolecular heterogeneity, catalytic and binding properties, and purification. Biochem J. 1981 Dec 01; 199(3):749-56. . View in PubMed

The importance and regulation of hepatic glutathione Yale J Biol Med. 1981 Nov-Dec; 54(6):497-502. . View in PubMed

Inhibition of rat hepatic thyroxine 5'-monodeiodinase by propylthiouracil: relation to site of interaction of thyroxine and glutathione J Endocrinol Invest. 1981 Oct-Dec; 4(4):379-87. . View in PubMed

The hepatocellular uptake and biliary excretion of endotoxin in the rat Hepatology. 1981 Sep-Oct; 1(5):401-7. . View in PubMed

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis Hepatology. 1981 Sep-Oct; 1(5):431-5. . View in PubMed

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Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats J Biol Chem. 1981 Mar 10; 256(5):2115-7. . View in PubMed

Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells Endocrinology. 1981 Mar; 108(3):970-6. . View in PubMed

Direct protection against acetaminophen hepatotoxicity by propylthiouracilIn vivo and in vitro studies in rats and mice. J Clin Invest. 1981 Mar; 67(3):688-95. . View in PubMed

Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis Hepatology. 1981 Jan-Feb; 1(1):65-72. . View in PubMed

Extrahepatic obstruction in chronic alcoholic pancreatitis Alcohol Clin Exp Res. 1981 Jan; 5(1):110-8. . View in PubMed

Physiological significance of glutathione S-transferases Am J Physiol. 1980 Dec; 239(6):G439-44. . View in PubMed

Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in the rat Gastroenterology. 1980 Sep; 79(3):545-9. . View in PubMed

Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine J Chromatogr. 1980 Jun 27; 194(3):424-8. . View in PubMed

Bile acid tolerance tests: rationale Gastroenterology. 1980 Jun; 78(6):1654-5. . View in PubMed

Inhibition of hepatic metabolism of azathioprine by furosemide in human liver in vitro Biochem Pharmacol. 1980 May 15; 29(10):1439-41. . View in PubMed

PropylthiouracilA substrate for the glutathione S-transferases that competes with glutathione. J Biol Chem. 1980 Apr 25; 255(8):3508-13. . View in PubMed

Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat Biochem Pharmacol. 1980 Apr 15; 29(8):1205-8. . View in PubMed

Effect of salicylates and phenobarbital on hepatic glutathione in the rat J Pharmacol Exp Ther. 1980 Feb; 212(2):240-5. . View in PubMed

Common bile duct stenosis from chronic pancreatitis: a clinical and pathologic spectrum Medicine (Baltimore). 1979 Nov; 58(6):385-412. . View in PubMed

Pruritus, cimetidine and polycythemia N Engl J Med. 1979 02 22; 300(8):433-4. . View in PubMed

Significance of microscopic cholangitis in alcoholic liver disease Gastroenterology. 1978 Dec; 75(6):1045-50. . View in PubMed

Aplastic anemia associated with type B viral hepatitis Arch Intern Med. 1978 Oct; 138(10):1557-8. . View in PubMed

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Obstructive jaundice caused by hepatocellular carcinomaReport of three cases. Am J Dig Dis. 1978 Jul; 23(7):609-17. . View in PubMed

The effect of phenobarbital, probenecid and diethyl maleate on the pharmaco-kinetics and biliary excretion of ethacrynic acid in the rat J Pharmacol Exp Ther. 1978 May; 205(2):471-9. . View in PubMed

Glutathione S-transferase in human lymphoid cell lines and fractionated peripheral leucocytes Biochem J. 1978 Mar 01; 169(3):465-70. . View in PubMed

Inhibition of hepatic metabolism of azathioprine in vivo Gastroenterology. 1978 Jan; 74(1):90-2. . View in PubMed

Effect of dietary phenobarbital, 3,4-benzo(alpha)pyrene and 3-methylcholanthrene on hepatic, intestinal and renal glutathione s-transferase activities in the rat Biochem Pharmacol. 1978; 27(8):1284-7. . View in PubMed

Endocrine and metabolic alterations with food and water deprivation Am J Clin Nutr. 1977 Dec; 30(12):1953-62. . View in PubMed

The glutathione S-transferases of the small intestine in the rat Cancer Res. 1977 Mar; 37(3):788-91. . View in PubMed

Interaction of azathioprine and glutathione in the liver of the rat J Pharmacol Exp Ther. 1977 Mar; 200(3):479-86. . View in PubMed

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Enzymatic thiolysis of azathioprine in vitro Biochem Pharmacol. 1976 Nov 01; 25(21):2421-6. . View in PubMed

Comparison of renal and hepatic glutathione S-transferases in the rat Biochem J. 1976 Aug 15; 158(2):243-8. . View in PubMed

Drug induction and sex differences of renal glutathione S-transferases in the rat Biochem J. 1975 Aug; 150(2):259-62. . View in PubMed

Hepatic glutathione S-transferases: identification by gel filtration and in vitro inhibition by organic anions Proc Soc Exp Biol Med. 1975 May; 149(1):234-7. . View in PubMed

Drug induction of hepatic glutathione S-transferases in male and female rats* Biochem J. 1975 Feb; 146(2):351-6. . View in PubMed

Malabsorption secondary to mesenteric ischemia Am J Roentgenol Radium Ther Nucl Med. 1973 Oct; 119(2):352-8. . View in PubMed

Role of hepatic anion-binding protein in bromsulphthalein conjugation J Exp Med. 1973 Aug 01; 138(2):483-7. . View in PubMed

Postprandial serum bile acid for the detection of hepatobiliary disease JAMA. 1973 Jul 16; 225(3):292-3. . View in PubMed

Hepatobiliary diseases associated with serum antimitochondrial antibody (AMA) Am J Med. 1973 Jun; 54(6):725-30. . View in PubMed

Quantitative analysis of unconjugated and conjugated bile acids in duodenal fluid by densitometry after paper electrophoresis J Lipid Res. 1973 Mar; 14(2):224-8. . View in PubMed

Coproporphyrin I and 3 excretion in bile and urine J Clin Invest. 1972 Nov; 51(11):2895-9. . View in PubMed

Isolation of erythrocytes with normal protoporphyrin levels in erythropoietic protoporphyria N Engl J Med. 1968 May 16; 278(20):1077-81. . View in PubMed