Faculty

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Lily Dara

Assistant Professor of Medicine

Gastrointestinal Liver Diseases

HMR 512 2011 Zonal Avenue Mail Code:9091 Health Sciences Campus Los Angeles

Contact

+1 323 442 5576

lily.dara@usc.edu

NIH, NIDDK: K08 Mentored Clinical Scientist Development Award, 2016-2021

Keck School of Medicine of USC: USC RCLD Junior Faculty Transition Award, 2015

American Association for the Study of Liver Disease: Presidential Poster of Distinction, 2011

American Association for the Study of Liver Disease: Resident Scholar Award, 2007

Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors Hepatol Commun. 2024 Sep 01; 8(9). . View in PubMed

Evaluation of markers of immunity in different metastatic immune microenvironments suggests more suppression within breast to liver metastases in breast cancer Breast Cancer Res Treat. 2024 Jul; 206(2):245-259. . View in PubMed

Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors Cell Death Dis. 2024 Feb 14; 15(2):140. . View in PubMed

A 68-Year-Old Woman With Unexplained Liver Enzyme Elevation and Active Chronic Hepatitis: Beware of Drug-Induced Autoimmune-Like HepatitisGastroenterology. 2024 02; 166(2):259-266. e1. . View in PubMed

Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity Front Immunol. 2023; 14:1137034. . View in PubMed

No Necroptosis in Hepatocytes: The Final Nail in the Coffin? Gastroenterology. 2022 12; 163(6):1492-1495.. View in PubMed

Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23 Nat Commun. 2022 03 17; 13(1):1440. . View in PubMed

Mechanisms of immune checkpoint inhibitor-mediated liver injury Acta Pharm Sin B. 2021 Dec; 11(12):3727-3739. . View in PubMed

Acute Hepatitis A and Hepatitis B Coinfection ACG Case Rep J. 2021 Nov; 8(11):e00702. . View in PubMed

We Are Not Immune: Racial and Ethnic Disparities in Autoimmune Liver Diseases Hepatology. 2021 11; 74(5):2876-2887. . View in PubMed

IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399. . View in PubMed

Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity J Biol Chem. 2021 Jan-Jun; 296:100300. . View in PubMed

Cell Death in Liver Diseases: A Review Int J Mol Sci. 2020 Dec 18; 21(24). . View in PubMed

Cell death in drug-induced liver injury Adv Pharmacol. 2019; 85:31-74. . View in PubMed

The Receptor Interacting Protein Kinases in the Liver Semin Liver Dis. 2018 02; 38(1):73-86. . View in PubMed

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis Int J Mol Sci. 2017 May 09; 18(5). . View in PubMed

Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications Liver Int. 2016 Feb; 36(2):158-65. . View in PubMed

The many faces of RIPK3: What about NASH? Hepatology. 2016 11; 64(5):1411-1413.. View in PubMed

Randomized trial of 1-week versus 2-week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding Hepatology. 2016 08; 64(2):549-55. . View in PubMed

Reply Hepatology. 2016 07; 64(1):312-3. . View in PubMed

Reply Hepatology. 2016 07; 64(1):308-9. . View in PubMed

Questions and controversies: the role of necroptosis in liver disease Cell Death Discov. 2016; 2:16089. . View in PubMed

A murder mystery in the liver: who done it and how? J Clin Invest. 2016 11 01; 126(11):4068-4071.. View in PubMed

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-? B. J Immunol. 2016 10 15; 197(8):3120-3129.. View in PubMed

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis Hepatology. 2015 Dec; 62(6):1847-57. . View in PubMed

Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity J Hepatol. 2015 Jul; 63(1):5-7. . View in PubMed

Cellular uptake and cytotoxicity of a near-IR fluorescent corrole-TiO2 nanoconjugate J Inorg Biochem. 2014 Nov; 140:39-44. . View in PubMed

MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer Hepatology. 2013 Jun; 57(6):2299-313. . View in PubMed

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. . View in PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed

The contribution of endoplasmic reticulum stress to liver diseases Hepatology. 2011 May; 53(5):1752-63. . View in PubMed

Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements World J Gastroenterol. 2008 Dec 07; 14(45):6999-7004. . View in PubMed

Dr. Dara is an NIH funded physician-scientist and clinician. She completed her Gastroenterology training at USC, is board certified in Internal Medicine and Gastroenterology and practices primarily as a hepatologist (liver specialist). Her clinical work is focused on autoimmune liver diseases such as Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC) and their variant syndromes. She is currently practicing at the Los Angeles General Medical Center where she sees patients with liver disease (including alcohol associated liver disease, fatty liver disease, viral hepatitis, liver failure, cirrhosis of the liver, drug-induced liver disease, metabolic and genetic disorders of the liver among many others) on the inpatient liver service and in the subspeciality liver clinics. At the Keck Hospital of USC she performs procedures such as endoscopies and colonoscopies in the new outpatient endoscopy unit. Her research focuses on disorders of the liver including drug induced liver injury and hepatotoxicity from medications, drugs, toxins, and herbal supplements in translational animal models as well as humans. She participates as an investigator on the NIH’s Drug Induced Liver Injury Network (DILIN) and is a reviewer for the LiverTox website. Additionally, she studies Autoimmune Hepatitis and PBC outcomes in patients with a focus on understanding the impact of ace and ethnicity, in particular Hispanic/Latinx ethnicity on outcomes.