Faculty
Douglas E. Feldman
Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2024 Oct 01; 134(19). . View in PubMed
MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells Cell Death Discov. 2023 Apr 28; 9(1):141. . View in PubMed
Bacteriophage antidefense genes that neutralize TIR and STING immune responses Cell Rep. 2023 04 25; 42(4):112305. . View in PubMed
Bacteriophage anti-defense genes that neutralize TIR and STING immune responses bioRxiv. 2022. . View in PubMed
HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B CellsMol Cell. 2020 01 16; 77(2):384-394. e4. . View in PubMed
An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb SilencingMol Cell. 2019 06 20; 74(6):1138-1147. e6. . View in PubMed
Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease Cell Rep. 2017 Oct 10; 21(2):482-494. . View in PubMed
Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2013 Jul; 123(7):2832-49. . View in PubMed
The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex PLoS One. 2013; 8(2):e57312. . View in PubMed
Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed
Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. . View in PubMed
Hypoxia and the unfolded protein response Methods Enzymol. 2007; 435:275-93. . View in PubMed
Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae Mol Cancer Res. 2005 Dec; 3(12):669-77. . View in PubMed
The unfolded protein response: a novel component of the hypoxic stress response in tumors Mol Cancer Res. 2005 Nov; 3(11):597-605. . View in PubMed
Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding Mol Cell. 2003 Nov; 12(5):1213-24. . View in PubMed
1. Immunomodulation and immune engineering for the treatment of inflammation and fibrosis.
2. Roles of modified DNA bases in immune signaling and gene control.
2. Functional analysis of viral counter-immune systems.
Categories: Gene Control, Stem Cells, Cancer, Epigenetics, DNA modification, immune engineering, immunotherapy, fibrosis, AALD