Research Themes
Our Center serves as a focal point for faculty from throughout the University who join together with shared interests in Liver Diseases and other aspects of Digestive Diseases which are of common interest in the Themes.
Themes of the Center are the following:
- Viral Hepatitis and Hepatocellular Carcinoma
- Steatohepatitis and fibrosis
- Liver Injury: hepatotoxicity (inflammation, signal transduction, free radical/oxidative stress) and mitochondria
- Repair, Regenerative Medicine, and Developmental Biology
Theme 1: Viral Hepatitis and Hepatocellular Carcinoma
This theme has been longstanding in our Center. Liver Center members associated with this theme study molecular virology and pathogenesis HBV and HCV and their role in liver cancer development.
| Theme 1 Coordinator: James Ou, Ph.D. Molecular, Microbiology & Immunology |
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| Viral Hepatitis: | Hepatocellular Carcinoma: | ||
| Tse-Ling Fong, MD | Medicine – GI/Liver | Kai Chen, PhD | Radiology |
| Lucy Golden, PhD | Medicine – GI/Liver | Anthony El-Kouheiry, MD | Medical Oncology |
| Helen Han, MD | Medicine – GI/Liver | Douglas Feldman, PhD | Pathology |
| Jeffrey Kahn, MD | Medicine – GI/Liver | Wendong Huang, PhD | Biochem. & Molec. Biol. |
| Saro Khemichian, MD | Medicine – GI/Liver | Cheng Ji, PhD | Medicine – GI/Liver |
| Andrea Kovacs, MD | Pediatrics/Pathology | Jeffrey Kahn, MD | Medicine – GI/Liver |
| Hugo R. Rosen, MD | Medicine – GI/Liver | Steve Kay, PhD | Michelson Center for Convergent Bioscience |
| Takeshi Saito, MD, PhD | Medicine – GI/Liver | Peter Kuhn, PhD | Michelson Center for Convergent Bioscience |
| Norah Terrault, MD, MPH | Medicine – GI/Liver | Amy Lee, PhD | Biochem. & Molec. Biol. |
| Weiming Yuan, PhD | Med/Molec. Micro. & Immunol. | Chengyu Liang, PhD | Molec. Micro. & Immunol. |
| Shelly Lu, MD | Medicine – GI/Liver | ||
| Keigo Machida, PhD | Molec. Micro. & Immunol. | ||
| Hugo R. Rosen, MD | Medicine – GI/Liver | ||
| Veronica W. Setiawan, PhD | Preventative Medicine | ||
| Linda Sher, MD | Surgery Hepat./Liver Trans. | ||
| Bangyan Stiles, PhD | Pharm. & Pharm. Sci. | ||
| Norah Terrault, MD, MPH | Medicine – GI/Liver | ||
| Hide Tsukamoto, DVM, PhD | Pathology | ||
| Jianming Xie, PhD | Pharmacy | ||
| Shuping Zhong, PhD | Medicine – GI/Liver | ||
Theme 2: Steatohepatitis and Fibrosis
This theme is a highly important component of the Liver Center and the main research focus of many of our investigators. The basic scientists in this theme study the pathophysiology of fatty liver disease, steatohepatitis, cell death and fibrosis sin the context of NASH. Additionally, the translational investigators in this theme study NASH/NAFLD in human subjects in order to better understand etiology, natural history, and complications of the disease and to develop therapeutic solutions for non-alcoholic steatohepatitis. An important component of this theme is our collaboration and partnership with the NIAAA supported SCRCALPD directed by Dr. Hide Tsukamoto.
| Theme 2 Coordinator: Hide Tsukamoto, DVM, PhD, Pathology |
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| Alcoholic and Nanoalcoholic steatohepatitis: Animal/Cell | Alcoholic and Nanoalcoholic steatohepatitis: Clinical Translational Research: | ||
| Laurie DeLeve, MD, PhD | Medicine – GI/Liver | Lida Chatzi, MD, PhD | Prev. Medicine |
| Doug Feldman, PhD | Pathology | Pinchas Cohen, MD | Gerontology |
| Lucy Golden-Mason, PhD | Medicine – GI/Liver | John Donovan, MD | Medicine – GI/Liver |
| Cheng Ji, PhD | Medicine – GI/Liver | Michael Goran, PhD | Preventative |
| Neil Kaplowitz, MD | Medicine – GI/Liver | Helen Han, MD | Medicine – GI/Liver |
| Steve Kay, PhD | Michelson Center for Convergent Bioscience | Neil Kaplowitz, MD | Medicine – GI/Liver |
| Rohit Kohli, MBBS | Pediatric GI/Liver | Brian Kim, MD | Medicine – GI/Liver |
| Changhan David Lee, PhD | Gerontology | Rohit Kohli, MBBS | Pediatric GI/Liver |
| Amy Lee, PhD | Biochem. & Molec. Biol. | Zhang-Xu Liu, PhD | Medicine – GI/Liver |
| Shelly Lu, MD | Medicine – GI/Liver | Valter D. Longo, PhD | Gerontology |
| Keigo Machida, PhD | Molec. Micro. & Immunol. | Shelly Lu, MD | Medicine – GI/Liver |
| Vassillios Papadopoulos, DPharm, PhD | School of Pharmacy | Kathleen Paige, MD | Med./Endocrinology |
| Hugo Rosen, MD | Medicine – GI/Liver | Hugo R. Rosen, MD | Medicine – GI/Liver |
| Takeshi Saito, MD, PhD | Medicine – GI/Liver | Veronica W. Setiawan, PhD | Preventative Medicine |
| Michael Stallcup, PhD | Biochem. & Molec. Biol. | Andrew Stolz, MD | Medicine – GI/Liver |
| Bangyan Stiles, PhD | Pharm. & Pharm. Sci. | Norah Terrault, MD, MPH | Medicine – GI/Liver |
| Tin Aung Than, MD | Medicine – GI/Liver | Liyun Yuan, MD, PhD | Medicine – GI/Liver |
| Hide Tsukamoto, DVM, PhD | Pathology | Fibrosis: | |
| Sanda Win, MD, PhD | Medicine – GI/Liver | Kinji Asahina, PhD | Pathology |
| Laurie DeLeve, MD, PhD | Medicine – GI/Liver | ||
| Andrea Kovacs, MD | Pedi./Pathology | ||
| Keigo Machida, PhD | Molec. Micro. & Immunol. | ||
| Anisa Shaker, MD | Medicine – GI/Liver | ||
| Hide Tsukamoto, DVM, PhD | Pathology | ||
| Kasper Wang, MD | Pediatrics | ||
| Young (Tiger) Zhang, PhD | Pharmacy | ||
Theme 3: Liver Injury
The Liver Center members in this theme focus on metabolic liver disease and mitochondrial pathobiology.
| Theme 3 Coordinator: Neil Kaplowitz, MD – Medicine – GI/Liver |
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| Mitochondrial Pathobiology in Liver Disease: | Hepatotoxicity and Inflammation: | ||
| Pinchas Cohen, MD | Gerontology | Lily Dara, MD | Medicine – GI/Liver |
| Doug Feldman, PhD | Pathology | Laurie DeLeve, MD, PhD | Medicine – GI/Liver |
| Neil Kaplowitz MD | Medicine – GI/Liver | Cheng Ji, PhD | Medicine – GI/Liver |
| Changhan David Lee, PhD | Gerontology | Neil Kaplowitz, MD | Medicine – GI/Liver |
| Vassillios Papadopoulos, DPharm, PhD | Pharm. & Pharm. Sci. | Amy Lee, PhD | Biochem. & Molec. Biol. |
| Bangyan Stiles, PhD | Pharm. & Pharm. Sci. | Shelly Lu, MD | Medicine – GI/Liver |
| Tin Aung Than, MD | Medicine – GI/Liver | Andrew Stolz, MD | Medicine – GI/Liver |
| John Tower, PhD | Gerontology | Tin Aung Than, PhD | Medicine – GI/Liver |
| Hide Tsukamoto, DVM, PhD | Pathology | Sanda Win, MD, PhD | Medicine – GI/Liver |
| Sanda Win, MD, PhD | Medicine – GI/Liver | ||
Theme 4: Repair, Regenerative Medicine and Developmental Biology
The Liver Center members in this theme focus on the mechanisms of repair and regeneration after injury and in the development in both the liver and luminal GI tract.
| Theme 4 Coordinators: Laurie D. DeLeve, MD, PhD & Lucy Golden-Mason, PhD – Medicine – GI/Liver |
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| Liver IRRD: | Gut Injury and IRRD: | ||
| Kinji Asahina, PhD | Pathology | Mark Frey, MD | Pediatrics |
| Laurie DeLeve, MD, PhD | Medicine – GI/Liver | Tracy Grikscheit, MD | Pediatric Surgery |
| Lucy Golden-Mason, PhD | Medicine – GI/Liver | Valter D. Longo, PhD | Gerontology |
| Rohil Kohli, MBBS | Pediatrics/GI/Liver | Brent Polk, MD | Pediatrics |
| Le A. Trinh, PhD | Biological Sciences | Ling Shao, MD | Medicine – GI/Liver |
| Zhang-Xu Liu, PhD | Medicine – GI/Liver | Anisa Shaker, MD | Medicine – GI/Liver |
| Valter D. Longo, PhD | Gerontology | Michael Stallcup, PhD | Biochem. & Molec. Biol. |
| Nirmala Mavila, PhD | Medicine – GI/Liver | ||
| Vassillios Papadopoulos, DPharm, PhD | Pharm. & Pharm. Sci. | ||
| Hugo R. Rosen, MD | Medicine – GI/Liver | ||
| Takeshi Saito, MD, PhD | Medicine – GI/Liver | ||
| Michael Stallcup, PhD | Biochem. & Molec. Biol. | ||
| Hide Tsukamoto, DVM, PhD | Pathology | ||
| Kasper Wang, MD | Pediatric Surgery | ||