Female Protection Against Diabetic Kidney Disease Is Regulated by Kidney-Specific AMPK Activity Diabetes. 2024 Jul 01; 73(7):1167-1177. . View in PubMed

Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and diseaseCell Stem Cell. 2024 Jun 06; 31(6):921-939. e17. . View in PubMed

Investigation of Basolateral Targeting Micelles for Drug Delivery Applications in Polycystic Kidney Disease Biomacromolecules. 2024 May 13; 25(5):2749-2761. . View in PubMed

Oral delivery of nanomedicine for genetic kidney disease PNAS Nexus. 2024 May; 3(5):pgae187. . View in PubMed

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids bioRxiv. 2023 May 25. . View in PubMed

Association of Longitudinal Urinary Metabolic Biomarkers With ADPKD Severity and Response to Metformin in TAME-PKD Clinical Trial Participants Kidney Int Rep. 2023 Mar; 8(3):467-477. . View in PubMed

In vitro delivery of mTOR inhibitors by kidney-targeted micelles for autosomal dominant polycystic kidney disease SLAS Technol. 2023 08; 28(4):223-229. . View in PubMed

Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial Clin J Am Soc Nephrol. 2022 04; 17(4):507-517. . View in PubMed

Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice Front Mol Biosci. 2022; 9:1001941. . View in PubMed

Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model Am J Physiol Renal Physiol. 2022 01 01; 322(1):F27-F41. . View in PubMed

Association of Baseline Urinary Metabolic Biomarkers with ADPKD Severity in TAME-PKD Clinical Trial Participants Kidney360. 2021 May; 2(5):795-808. . View in PubMed

Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD) Kidney Int. 2021 09; 100(3):684-696. . View in PubMed

Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease J Control Release. 2021 01 10; 329:1198-1209. . View in PubMed

Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors Nat Commun. 2021 06 15; 12(1):3641. . View in PubMed

Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial Kidney360. 2020 Dec 31; 1(12):1363-1372. . View in PubMed

AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system Autophagy. 2020 08; 16(8):1550-1552. . View in PubMed

Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness FASEB J. 2020 05; 34(5):7036-7057. . View in PubMed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction SystemMol Cell. 2020 03 05; 77(5):951-969. e9. . View in PubMed

MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury Am J Kidney Dis. 2019 03; 73(3):429-431. . View in PubMed

Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells Methods Cell Biol. 2019; 153:185-203. . View in PubMed

AMPK phosphorylation of the ß1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1513-F1525. . View in PubMed

ß1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells J Biol Chem. 2018 07 20; 293(29):11612-11624. . View in PubMed

"First do no harm": kidney drug targeting to avoid toxicity in ADPKD Am J Physiol Renal Physiol. 2018 09 01; 315(3):F535-F536. . View in PubMed

A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease Am J Nephrol. 2018; 47(5):352-360. . View in PubMed

Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease Curr Opin Nephrol Hypertens. 2017 09; 26(5):375-383. . View in PubMed

Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats Front Physiol. 2017; 8:227. . View in PubMed

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney Sci Rep. 2016 10 26; 6:35952. . View in PubMed

Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28. . View in PubMed

Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900. . View in PubMed

Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. . View in PubMed

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action J Clin Invest. 2015 Sep; 125(9):3433-48. . View in PubMed

Muc1 is protective during kidney ischemia-reperfusion injury Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. . View in PubMed

Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation Cell Cycle. 2015; 14(18):2914-23. . View in PubMed

Akt recruits Dab2 to albumin endocytosis in the proximal tubule Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. . View in PubMed

A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. . View in PubMed

Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy Crit Care. 2014 Sep 02; 18(5):501. . View in PubMed

Epithelial transport during septic acute kidney injury Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. . View in PubMed

Hemodialysis for the treatment of severe accidental hypothermia Semin Dial. 2014 May-Jun; 27(3):295-7. . View in PubMed

Opening lines of communication in the distal nephron J Clin Invest. 2013 Oct; 123(10):4139-41. . View in PubMed

AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. . View in PubMed

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin J Biol Chem. 2013 Sep 27; 288(39):27849-60. . View in PubMed

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1 Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90. . View in PubMed

Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. . View in PubMed

Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells PLoS One. 2013; 8(10):e78019. . View in PubMed

Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase J Biol Chem. 2012 Sep 28; 287(40):33389-400. . View in PubMed

AMP-activated protein kinase regulation of kidney tubular transport Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. . View in PubMed

Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites J Biol Chem. 2011 Oct 28; 286(43):37830-40. . View in PubMed

Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. . View in PubMed

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2462-7. . View in PubMed

CFTR regulation by phosphorylation Methods Mol Biol. 2011; 741:471-88. . View in PubMed

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. . View in PubMed

SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. . View in PubMed

PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells J Biol Chem. 2010 Aug 06; 285(32):24676-85. . View in PubMed

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria Cell. 2010 Jul 23; 142(2):270-83. . View in PubMed

Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel J Biol Chem. 2010 Jul 09; 285(28):21671-8. . View in PubMed

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. . View in PubMed

AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84. . View in PubMed

Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. . View in PubMed

Role of the energy sensor AMP-activated protein kinase in renal physiology and disease Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. . View in PubMed

AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101. . View in PubMed

AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. . View in PubMed

Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells J Biol Chem. 2009 Feb 27; 284(9):5774-83. . View in PubMed

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2 J Biol Chem. 2009 Jan 02; 284(1):150-157. . View in PubMed

Mechanisms of ENaC regulation and clinical implications J Am Soc Nephrol. 2008 Oct; 19(10):1845-54. . View in PubMed

Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. . View in PubMed

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2 J Biol Chem. 2006 Sep 08; 281(36):26159-69. . View in PubMed

Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation J Biol Chem. 2006 Feb 17; 281(7):4231-41. . View in PubMed

Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71. . View in PubMed

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells J Biol Chem. 2005 May 06; 280(18):17608-16. . View in PubMed

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308. . View in PubMed

Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells J Biol Chem. 2003 Jan 10; 278(2):998-1004. . View in PubMed

Yeast two-hybrid identification and analysis of protein interactions with CFTR Methods Mol Med. 2002; 70:365-81. . View in PubMed

Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase J Clin Invest. 2000 Jun; 105(12):1711-21. . View in PubMed

The urine/plasma electrolyte ratio: a predictive guide to water restriction Am J Med Sci. 2000 Apr; 319(4):240-4. . View in PubMed

Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation J Cell Physiol. 1996 Apr; 167(1):60-71. . View in PubMed

Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72. . View in PubMed

Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56. . View in PubMed

Control of intracellular pH during regulatory volume decrease in HL-60 cells Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66. . View in PubMed

Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells Biorheology. 1992 Mar-Jun; 29(2-3):295-309. . View in PubMed

Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61. . View in PubMed

Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate Radiat Res. 1988 Jun; 114(3):579-88. . View in PubMed

Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells Radiat Res. 1988 Jan; 113(1):191-8. . View in PubMed