Computer-based medical informatics and electronic patient records represent an enormous but largely untapped opportunity for clinical research and collaboration. USC and CHLA are implementing a comprehensive electronic infrastructure that will interact with our electronic health record (EHR) systems helping researchers to access clinical data from the EHRs for IRB-approved research. There are two main components to this infrastructure, which is being created with resources from the USC Office of the Provost, Keck Medical Center, Keck School of Medicine, the USC Clinical Trials Office, Children’s Hospital Los Angeles and the Southern California Clinical and Translational Science Institute.