Faculty
Lucio Comai
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Staggered immunization with mRNA vaccines encoding SARS-CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2406332121. . View in PubMed
Mbnl2 loss alters novel context processing and impairs object recognition memory iScience. 2023 May 19; 26(5):106732. . View in PubMed
Impedimetric Sensing: An Emerging Tool for Combating the COVID-19 Pandemic Biosensors (Basel). 2023 Jan 30; 13(2). . View in PubMed
Potent NKT cell ligands overcome SARS-CoV-2 immune evasion to mitigate viral pathogenesis in mouse models PLoS Pathog. 2023 03; 19(3):e1011240. . View in PubMed
Differential Outcomes of Infection by Wild-Type SARS-CoV-2 and the B1. 617. 2 and B. 1. 1. 529 Variants of Concern in K18-hACE2 Transgenic Mice. Viruses. 2023 12 29; 16(1). . View in PubMed
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis Proc Natl Acad Sci U S A. 2022 06 28; 119(26):e2122897119. . View in PubMed
A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice Front Immunol. 2022; 13:1007955. . View in PubMed
Mbnl1 and Mbnl2 regulate brain structural integrity in mice Commun Biol. 2021 11 30; 4(1):1342. . View in PubMed
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells BMC Mol Cell Biol. 2020 Oct 14; 21(1):71. . View in PubMed
Measurements of Hydrogen Peroxide and Oxidative DNA Damage in a Cell Model of Premature Aging Methods Mol Biol. 2020; 2144:245-257. . View in PubMed
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase d Elongation Mol Cell Biol. 2017 02 01; 37(3). . View in PubMed
Recent advances in understanding the role of lamins in health and disease F1000Res. 2016; 5:2536. . View in PubMed
Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy Sci Rep. 2016 08 03; 6:30999. . View in PubMed
Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation EBioMedicine. 2015 Sep; 2(9):1034-47. . View in PubMed
Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms Sci Rep. 2015 Mar 12; 5:9042. . View in PubMed
Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells Aging Cell. 2014 04; 13(2):367-78. . View in PubMed
A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction Aging (Albany NY). 2012 Aug; 4(8):567-77. . View in PubMed
RNA splicing is responsive to MBNL1 dose PLoS One. 2012; 7(11):e48825. . View in PubMed
Lamin A, farnesylation and aging Exp Cell Res. 2012 Jan 01; 318(1):1-7. . View in PubMed
Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex J Biol Chem. 2011 Nov 04; 286(44):38427-38438. . View in PubMed
RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP EMBO Rep. 2011 Jul 01; 12(7):735-42. . View in PubMed
Cell cycle-regulated association between the Werner syndrome protein and its molecular partners Cell Cycle. 2011 Jun 15; 10(12):2038-40. . View in PubMed
Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells Aging (Albany NY). 2011 Apr; 3(4):395-406. . View in PubMed
Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis Exp Cell Res. 2011 Feb 01; 317(3):319-29. . View in PubMed
Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes J Immunol. 2010 Dec 01; 185(11):6985-98. . View in PubMed
Processing of human telomeres by the Werner syndrome protein Cell Cycle. 2010 Aug 15; 9(16):3137-8. . View in PubMed
Altered nuclear functions in progeroid syndromes: a paradigm for aging research ScientificWorldJournal. 2009 Dec 16; 9:1449-62. . View in PubMed
Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain Biochemistry. 2009 Aug 11; 48(31):7525-32. . View in PubMed
Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity Aging (Albany NY). 2009 Mar 17; 1(3):289-302. . View in PubMed
Perturbation of wild-type lamin A metabolism results in a progeroid phenotype Aging Cell. 2008 Jun; 7(3):355-67. . View in PubMed
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening Mol Cell Biol. 2008 Mar; 28(6):1892-904. . View in PubMed
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system J Cell Biol. 2008 Jan 14; 180(1):67-81. . View in PubMed
Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features PLoS One. 2008; 3(12):e3968. . View in PubMed
Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor Am J Physiol Cell Physiol. 2007 May; 292(5):C1617-24. . View in PubMed
Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing EMBO J. 2006 Sep 20; 25(18):4271-83. . View in PubMed
CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction Nucleic Acids Res. 2006; 34(17):4752-66. . View in PubMed
Direct regulation of rRNA transcription by fibroblast growth factor 2 Mol Cell Biol. 2005 Nov; 25(21):9419-26. . View in PubMed
Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription J Gen Virol. 2005 Aug; 86(Pt 8):2315-2322. . View in PubMed
PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex Mol Cell Biol. 2005 Aug; 25(16):6899-911. . View in PubMed
MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1 J Biol Chem. 2005 Feb 18; 280(7):5773-80. . View in PubMed
A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis Nucleic Acids Res. 2005; 33(21):6861-7. . View in PubMed
The Werner syndrome protein at the crossroads of DNA repair and apoptosis Mech Ageing Dev. 2004 Aug; 125(8):521-8. . View in PubMed
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1 J Biol Chem. 2004 Apr 02; 279(14):13659-67. . View in PubMed
Mechanism of RNA polymerase I transcription Adv Protein Chem. 2004; 67:123-55. . View in PubMed
Coimmunoprecipitation assay for the detection of kinase-substrate interactions Methods Mol Biol. 2003; 218:277-84. . View in PubMed
The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF Curr Biol. 2002 Dec 23; 12(24):2142-6. . View in PubMed
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein Nucleic Acids Res. 2002 Sep 01; 30(17):3653-61. . View in PubMed
Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex J Biol Chem. 2001 Mar 30; 276(13):9896-902. . View in PubMed
Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A J Cell Biochem. 2001; 82(4):610-8. . View in PubMed
Functional interaction between Ku and the werner syndrome protein in DNA end processing J Biol Chem. 2000 Sep 15; 275(37):28349-52. . View in PubMed
Repression of RNA polymerase I transcription by the tumor suppressor p53 Mol Cell Biol. 2000 Aug; 20(16):5930-8. . View in PubMed
Inhibition of RNA polymerase I transcription in differentiated myeloid leukemia cells by inactivation of selectivity factor 1 Cell Growth Differ. 2000 Jan; 11(1):63-70. . View in PubMed
The nucleolus: a paradigm for cell proliferation and aging Braz J Med Biol Res. 1999 Dec; 32(12):1473-8. . View in PubMed
Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation Mol Cell Biol. 1999 Apr; 19(4):2872-9. . View in PubMed
A kinase activity associated with simian virus 40 large T antigen phosphorylates upstream binding factor (UBF) and promotes formation of a stable initiation complex between UBF and SL1 Mol Cell Biol. 1999 Apr; 19(4):2791-802. . View in PubMed
VirE1 is a specific molecular chaperone for the exported single-stranded-DNA-binding protein VirE2 in Agrobacterium Mol Microbiol. 1999 Mar; 31(6):1795-807. . View in PubMed
Agrobacterium VirD2 protein interacts with plant host cyclophilins Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7040-5. . View in PubMed
Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9544-9. . View in PubMed
SV40 large T antigen binds to the TBP-TAF(I) complex SL1 and coactivates ribosomal RNA transcription Genes Dev. 1997 Jun 15; 11(12):1605-17. . View in PubMed
The rDNA transcription machinery is assembled during mitosis in active NORs and absent in inactive NORs J Cell Biol. 1996 Apr; 133(2):235-46. . View in PubMed
Protection of megabase DNA from shearing Nucleic Acids Res. 1995 Oct 11; 23(19):3999-4000. . View in PubMed
Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits Science. 1994 Dec 23; 266(5193):1966-72. . View in PubMed
Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits Science. 1994 Dec 23; 266(5193):2015-8. . View in PubMed
The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1 Cell. 1992 Mar 06; 68(5):965-76. . View in PubMed