As climate change worsens droughts and jeopardizes water imports, California has been forced to rethink water sustainability. By Boki Muigai From left: Max Aung, PhD, and Lida ... Read More »
Researchers from the Keck School of Medicine of USC used advanced techniques to isolate and analyze individual immune cells to understand how they respond to the hepatitis C ... Read More »
![Keck School of Medicine of USC News Release Even "safe" air pollution levels can harm the developing brain, study finds In one of the first longitudinal studies of its kind, researchers from the Keck School of Medicine of USC found that everyday air pollution can alter brain development patterns in adolescents. Air pollution is known to contribute to disease, which is why regulators such as the Environmental Protection Agency (EPA) set limits on emissions. But mounting evidence suggests that even pollution levels long thought to be safe can increase the risk of health problems, including in the brain. Now, research from the Keck School of Medicine of USC, funded by the National Institutes of Health and the EPA, have shown that even levels of certain pollutants considered safe by the EPA are linked to changes in brain function over time. The study, just published in the journal Environment International, used brain scan data from more than 9,000 participants in the Adolescent Brain Cognitive Development (ABCD) study, the largest-ever nationwide study of youth brain health. Children exposed to more pollutants showed changes in connectivity between various brain regions. In some areas, they had more connections than normal; in other areas, they had fewer. "A deviation in any direction from a normal trajectory of brain development—whether brain networks are too connected or not connected enough—could be harmful down the line," said Devyn L. Cotter, MSc, a doctoral candidate in neuroscience at the Keck School of Medicine and first author of the study. Communication between regions of the brain help us navigate virtually every moment of our day, from the way we take in information about our surroundings to how we think and feel. Many of those critical connections develop between the ages of 9 and 12 and can influence whether children experience normal or atypical cognitive and emotional development. "Air quality across America, even though 'safe' by EPA standards, is contributing to changes in brain networks during this critical time, which may reflect an early biomarker for increased risk for cognitive and emotional problems later in life," said Megan M. Herting, PhD, associate professor of population and public health sciences at the Keck School of Medicine and the study's senior author. Changes in brain connectivity To explore the link between air pollution and brain development, Herting, Cotter and their colleagues analyzed functional MRI scans from 9,497 participants in the ABCD study. Baseline brain scans were collected from children, ages 9 to 10, and a subset of children had follow-up scans collected two years later, allowing researchers to observe how brain connectivity changed over time. In particular, they analyzed the salience, frontoparietal and default-mode brain networks, as well as the amygdala and hippocampus—key regions of the brain known to be involved in emotion, learning, memory and other complex functions. Next, the researchers used EPA and other data to map air quality at each child’s residence, including levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2) and ground-level ozone (O3). They then used advanced statistical tools to investigate how air pollution levels relate to changes in brain connectivity over time. In other words: are young brains developing differently when they are exposed to more pollution? Greater exposure to PM2.5 was linked to relative increases in functional connectivity between regions, while more exposure to NO2 predicted relative decreases in connectedness. Exposure to higher levels of O3 was associated with greater connections within the brain's cortex, but fewer connections between the cortex and other regions, such as the amygdala and hippocampus. To rule out other factors that could explain differences in brain development, the researchers controlled for sex, race/ethnicity, parental education level, household income, urban versus rural location and seasonality, as air pollution varies across winter and summer months. Tightening air quality rules The findings could prompt regulators to consider brain health, in addition to lung and cardiometabolic heath, when they set or adjust recommendations for air quality. While the EPA proposed strengthening standards for PM2.5 earlier this year, guidelines for annual NO2 have not changed since they were first set in 1971. "On average, air pollution levels are fairly low in the U.S., but we're still seeing significant effects on the brain," Cotter said. "That's something policymakers should take into account when they're thinking about whether to tighten the current standards." Cotter, Herting and their colleagues aim to look more closely at the chemical makeup of pollutants to determine how and why they cause harm in the brain, which could help further refine regulations. They also plan to continue using data from the ABCD study to analyze brain health over time. "Long term, does this lead to risk for psychopathology that continues to ramp up during mid- to late- adolescence? How does this affect people's trajectory of mental health?" Herting said. About this study In addition to Cotter and Herting, the study's other authors are Claire E. Campbell, Kirthana Sukumaran, Rob McConnell and Hedyeh Ahmadi from the Department of Population and Public Health Sciences, Keck School of Medicine of USC; Daniel A. Hackman from the USC Suzanne Dworak-Peck School of Social Work; Jiu-Chiuan Chen from the Department of Neurology, Keck School of Medicine of USC; Kiros Berhane from the Department of Biostatistics, Columbia University Mailman School of Public Health; and Joel Schwartz from the Department of Environmental Health, Harvard T. H. Chan School of Public Health. This work was supported by National Institutes of Health [NIEHS R01ES032295, R01ES031074, P30ES007048-23S1, 3P30ES000002-55S1] and the Environmental Protection Agency [RD 83587201, RD 83544101].](https://keck2.usc.edu/wp-content/uploads/2023/06/iStock-502160532-copy-scaled.jpg)
In one of the first longitudinal studies of its kind, researchers from the Keck School of Medicine of USC found that everyday air pollution can alter brain development ... Read More »
By Cristy Lytal From left, Fokion Glykofrydis, Nils Lindström, Leonardo Morsut, and Connor Fausto (Photo by Sergio Bianco) To help patients in need of transplants, ... Read More »
New research from the Keck School of Medicine of USC shows that air pollution particles activate a cellular defense mechanism known as autophagy, which may reduce the ability ... Read More »
By Hinde Kast 3D Illustration Concept of Human Internal Digestive Organ Liver Anatomy. (Image: iStock) Immigrant adults with liver cancer in the United States have higher ... Read More »
A USC researcher has identified base pairs of DNA that play a crucial role in human disease. By Carolyn Barnes Image: iStock “Why do humans ... Read More »
By Mollie Barnes Two types of otoacoustic emissions recorded from the cochlea of a normally hearing human subject across five octaves and multiple stimulus levels (denoted by ... Read More »
By Cristy Lytal From left, study authors Jiya Eerdeng, Ivon Garcia, Rong Lu, Charles Bramlett, Mary Vergel-Rodriguez, and Yeachan Lee (Photo by Bowen Wang) Why do ... Read More »