Faculty2017-09-07T10:35:44-07:00

Faculty

Gage Dekoeyer Crump

Gage Dekoeyer Crump

Professor of Stem Cell & Regenerative Medicine;Director, DSR PhD Program;Vice Chair, Department of Stem Cell Biology and Regenerative Medicine
Medicine
BCC 406 1425 San Pablo Street Health Sciences Campus Los Angeles

Repurposing of a gill gene regulatory program for outer-ear evolution. Nature. 2025 Mar; 639(8055):682-690.. View in PubMed

Cellular transitions during cranial suture establishment in zebrafish. Nat Commun. 2024 Aug 13; 15(1):6948.. View in PubMed

Reassessing the embryonic origin and potential of craniofacial ectomesenchyme. Semin Cell Dev Biol. 2023 03 30; 138:45-53.. View in PubMed

Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw. Dev Cell. 2023 03 27; 58(6):461-473.e7.. View in PubMed

Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nat Commun. 2022 01 10; 13(1):13.. View in PubMed

The developing mouse coronal suture at single-cell resolution. Nat Commun. 2021 08 10; 12(1):4797.. View in PubMed

Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biol Open. 2021 02 25; 10(2).. View in PubMed

Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis. Ann Rheum Dis. 2020 12; 79(12):1625-1634.. View in PubMed

Lineage analysis reveals an endodermal contribution to the vertebrate pituitary. Science. 2020 10 23; 370(6515):463-467.. View in PubMed

Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Proc Natl Acad Sci U S A. 2020 10 06; 117(40):24876-24884.. View in PubMed

Zebrafish prrx1a mutants have normal hearts. Nature. 2020 09; 585(7826):E14-E16.. View in PubMed

Skeletal stem cells: insights into maintaining and regenerating the skeleton. Development. 2020 03 11; 147(5).. View in PubMed

Fox proteins are modular competency factors for facial cartilage and tooth specification. Development. 2018 06 26; 145(12).. View in PubMed

Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw. Dev Cell. 2018 02 05; 44(3):337-347.e5.. View in PubMed

Nr2f1a balances atrial chamber and atrioventricular canal size via BMP signaling-independent and -dependent mechanisms. Dev Biol. 2018 02 01; 434(1):7-14.. View in PubMed

Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Commun. 2017 10 03; 8(1):769.. View in PubMed

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353.. View in PubMed

Genome-wide analysis of facial skeletal regionalization in zebrafish. Development. 2017 08 15; 144(16):2994-3005.. View in PubMed

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Sci Rep. 2017 05 31; 7(1):2497.. View in PubMed

Building and maintaining joints by exquisite local control of cell fate. Wiley Interdiscip Rev Dev Biol. 2017 01; 6(1).. View in PubMed

Ancient origin of lubricated joints in bony vertebrates. Elife. 2016 07 19; 5.. View in PubMed

Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration. Development. 2016 06 15; 143(12):2066-76.. View in PubMed

Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genet. 2016 Apr; 12(4):e1005967.. View in PubMed

Lessons on skeletal cell plasticity from studying jawbone regeneration in zebrafish. Bonekey Rep. 2016; 5:853.. View in PubMed

Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell. 2015 Nov 09; 35(3):358-65.. View in PubMed

Dynamic epithelia of the developing vertebrate face. Curr Opin Genet Dev. 2015 Jun; 32:66-72.. View in PubMed

Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics. Development. 2015 Mar 15; 142(6):1089-94.. View in PubMed

Zebrafish Craniofacial Development: A Window into Early Patterning. Curr Top Dev Biol. 2015; 115:235-69.. View in PubMed

Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73.. View in PubMed

Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a. Development. 2014 Sep; 141(18):3583-93.. View in PubMed

Wnt-dependent epithelial transitions drive pharyngeal pouch formation. Dev Cell. 2013 Feb 11; 24(3):296-309.. View in PubMed

Regenerative potential of the zebrafish corneal endothelium. Exp Eye Res. 2013 Jan; 106:1-4.. View in PubMed

New perspectives on pharyngeal dorsoventral patterning in development and evolution of the vertebrate jaw. Dev Biol. 2012 Nov 15; 371(2):121-35.. View in PubMed

An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012 Sep; 8(9):e1002938.. View in PubMed

The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell. 2012 Jul 17; 23(1):58-70.. View in PubMed

Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. Dev Biol. 2012 Feb 15; 362(2):230-41.. View in PubMed

Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012; 8(5):e1002710.. View in PubMed

Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development. 2011 Dec; 138(23):5147-56.. View in PubMed

Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. Development. 2011 Dec; 138(23):5135-46.. View in PubMed

Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo. Development. 2011 Aug; 138(15):3113-23.. View in PubMed

Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. Development. 2010 Aug 01; 137(15):2527-37.. View in PubMed

Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development. 2010 Jun; 137(11):1843-52.. View in PubMed

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development. 2008 Jun; 135(11):1935-46.. View in PubMed

Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nat Neurosci. 2006 Dec; 9(12):1488-98.. View in PubMed

Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development. 2006 Jul; 133(14):2661-9.. View in PubMed

Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development. 2006 Mar; 133(6):1069-77.. View in PubMed

A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development. 2005 Mar; 132(5):1069-83.. View in PubMed

Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11; 307(5711):929-32.. View in PubMed

An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development. 2004 Nov; 131(22):5703-16.. View in PubMed

An integrin-dependent role of pouch endoderm in hyoid cartilage development. PLoS Biol. 2004 Sep; 2(9):E244.. View in PubMed

Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish. Development. 2003 Apr; 130(7):1339-51.. View in PubMed

Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Neuron. 2001 Aug 02; 31(2):277-87.. View in PubMed

The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. Neuron. 2001 Jan; 29(1):115-29.. View in PubMed

The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons. Neuron. 1998 Jan; 20(1):55-67.. View in PubMed

Olfactory recognition and discrimination in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1996; 61:157-64.. View in PubMed

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