Faculty
Neil Kaplowitz
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American Liver Foundation: Distinguished Scientific Achievement Award, 2008
Western Society of Clinical Investigation: Mayo Soley Award, 2007
American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006
Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006
American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005
American Liver Foundation: Greater Los Angeles Medical Honoree, 2000
New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994
Department of Veterans Affairs : William S. Middleton Award, 1993
NIH: Merit Award, 1992
Association of American Physicians: Member, 1988
Western Gastroenterology : Research Prize, 1986
Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding Neurobiol Dis. 2024 Jun 15; 106570. . View in PubMed
Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolismCell Host Microbe. 2024 Jan 10; 32(1):48-62. e9. . View in PubMed
Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death Front Cell Dev Biol. 2024; 12:1359152. . View in PubMed
Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries Liver Int. 2023 08; 43(8):1749-1760. . View in PubMed
Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081. . View in PubMed
Endoplasmic reticulum stress in liver diseases Hepatology. 2023 02 01; 77(2):619-639. . View in PubMed
Introducing Laurie DeLeve, MD. , Ph. D. , Our 2022 AASLD President. Hepatology. 2022 03; 75(3):514-517. . View in PubMed
Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-ß Front Physiol. 2022; 13:930402. . View in PubMed
The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice Acta Pharm Sin B. 2022 Jan; 12(1):182-196. . View in PubMed
Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis Hepatology. 2021 12; 74(6):3127-3145. . View in PubMed
Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity Hepatology. 2021 12; 74(6):3486-3496. . View in PubMed
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry J Hepatol. 2021 07; 75(1):86-97. . View in PubMed
Alcohol, Fasting, and Therapeutic Dosing of Acetaminophen: A Perfect Storm Hepatology. 2021 05; 73(5):1634-1636. . View in PubMed
Clinical Characteristics and Outcome of Drug-Induced Liver Injury in the Older Patients: From the Young-Old to the Oldest-Old Clin Pharmacol Ther. 2021 04; 109(4):1147-1158. . View in PubMed
IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399. . View in PubMed
REPLY Hepatol Commun. 2020 Nov; 4(11):1725. . View in PubMed
Markedly Elevated Serum Aspartate Aminotransferase to Alanine Aminotransferase Ratio: A Clue to Hepatic Neoplasia Hepatol Commun. 2020 Jul; 4(7):1099-1101. . View in PubMed
Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense Hepatology. 2020 05; 71(5):1530-1532. . View in PubMed
Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice Am J Pathol. 2020 01; 190(1):57-67. . View in PubMed
Gut Microbiota and Liver Injury (I)-Acute Liver Injury Adv Exp Med Biol. 2020; 1238:23-37. . View in PubMed
Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure Gastroenterology. 2019 08; 157(2):552-568. . View in PubMed
Drug-induced liver injury Nat Rev Dis Primers. 2019 08 22; 5(1):58. . View in PubMed
Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury J Clin Invest. 2019 12 02; 129(12):5278-5293. . View in PubMed
The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects Int J Mol Sci. 2018 Nov 20; 19(11). . View in PubMed
Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure Hepatol Commun. 2018 Nov; 2(11):1293-1298. . View in PubMed
Herb-Induced Liver Injury: A Global Concern Chin J Integr Med. 2018 Sep; 24(9):643-644. . View in PubMed
Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy Br J Pharmacol. 2018 10; 175(19):3747-3757. . View in PubMed
Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice J Hepatol. 2018 07; 69(1):51-59. . View in PubMed
New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases Hepatology. 2018 05; 67(5):2013-2024. . View in PubMed
The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading Redox Biol. 2018 04; 14:164-177. . View in PubMed
Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis Int J Mol Sci. 2017 May 09; 18(5). . View in PubMed
Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy Hepatol Commun. 2017 12; 1(10):1070-1084. . View in PubMed
Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration? Hepatology. 2017 11; 66(5):1381-1383.. View in PubMed
Death and liver transplantation within 2 years of onset of drug-induced liver injury Hepatology. 2017 10; 66(4):1275-1285. . View in PubMed
Protective role of p53 in acetaminophen hepatotoxicity Free Radic Biol Med. 2017 05; 106:111-117. . View in PubMed
Mitochondrial remodeling in the liver following chronic alcohol feeding to rats Free Radic Biol Med. 2017 01; 102:100-110. . View in PubMed
The role of MAP2 kinases and p38 kinase in acute murine liver injury models Cell Death Dis. 2017 06 29; 8(6):e2903. . View in PubMed
Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria Antioxid Redox Signal. 2017 02 10; 26(5):207-220. . View in PubMed
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. . View in PubMed
HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer Clin Cancer Res. 2016 Mar 15; 22(6):1371-7. . View in PubMed
Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications Liver Int. 2016 Feb; 36(2):158-65. . View in PubMed
Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments PLoS Comput Biol. 2016 12; 12(12):e1005253. . View in PubMed
The many faces of RIPK3: What about NASH? Hepatology. 2016 11; 64(5):1411-1413.. View in PubMed
Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury J Hepatol. 2016 09; 65(3):532-42. . View in PubMed
Reply Hepatology. 2016 07; 64(1):312-3. . View in PubMed
Reply Hepatology. 2016 07; 64(1):308-9. . View in PubMed
Is Sensitivity the Key Measure to Predict Acute Liver Failure in Drug-Induced Liver Injury Patients? Clin Gastroenterol Hepatol. 2016 06; 14(6):918.. View in PubMed
c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src Hepatology. 2016 06; 63(6):1987-2003. . View in PubMed
Questions and controversies: the role of necroptosis in liver disease Cell Death Discov. 2016; 2:16089. . View in PubMed
A murder mystery in the liver: who done it and how? J Clin Invest. 2016 11 01; 126(11):4068-4071.. View in PubMed
Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-? B. J Immunol. 2016 10 15; 197(8):3120-3129.. View in PubMed
Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy Sci Rep. 2015 Dec 11; 5:18017. . View in PubMed
Alcoholic foamy degeneration and alcoholic fatty liver with jaundice: Often overlooked causes of jaundice and hepatic decompensation that can mimic alcoholic hepatitis Clin Liver Dis (Hoboken). 2015 Dec; 6(6):145-148. . View in PubMed
Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis Hepatology. 2015 Dec; 62(6):1847-57. . View in PubMed
Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database Drug Saf. 2015 Nov; 38(11):1103-13. . View in PubMed
Inhibition of immune tolerance unmasks drug-induced allergic hepatitis Hepatology. 2015 Aug; 62(2):346-8. . View in PubMed
Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients Eur J Cancer. 2015 Jul; 51(10):1293-302. . View in PubMed
Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity J Hepatol. 2015 Jul; 63(1):5-7. . View in PubMed
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity J Hepatol. 2015 Jun; 62(6):1367-74. . View in PubMed
Reply: To PMID 24704526 Gastroenterology. 2015 Feb; 148(2):452-3. . View in PubMed
Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways J Hepatol. 2015 Jan; 62(1):219-33. . View in PubMed
In vitro assays of mitochondrial function/dysfunction Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. . View in PubMed
Reply: To PMID 24704526 Gastroenterology. 2014 Dec; 147(6):1442. . View in PubMed
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis J Hepatol. 2014 Nov; 61(5):1126-34. . View in PubMed
The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future Drug Saf. 2014 Nov; 37 Suppl 1:S1-7. . View in PubMed
Liver safety assessment in special populations (hepatitis B, C, and oncology trials) Drug Saf. 2014 Nov; 37 Suppl 1:S57-62. . View in PubMed
Cell death and cell death responses in liver disease: mechanisms and clinical relevanceGastroenterology. 2014 Oct; 147(4):765-783. e4. . View in PubMed
Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injuryGastroenterology. 2014 Jul; 147(1):109-118. e5. . View in PubMed
Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway Chem Res Toxicol. 2014 May 19; 27(5):794-804. . View in PubMed
Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways Hepatology. 2014 Apr; 59(4):1543-1554. . View in PubMed
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death Cell Death Dis. 2014 Jan 09; 5:e989. . View in PubMed
Mechanisms of drug-induced liver injury Clin Liver Dis. 2013 Nov; 17(4):507-18vii. . View in PubMed
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading J Hepatol. 2013 Oct; 59(4):805-13. . View in PubMed
Role of Mitochondria in Alcoholic Liver Disease Curr Pathobiol Rep. 2013 Sep 01; 1(3):159-168. . View in PubMed
Avoiding idiosyncratic DILI: two is better than one Hepatology. 2013 Jul; 58(1):15-7. . View in PubMed
Mitochondrial glutathione: features, regulation and role in disease Biochim Biophys Acta. 2013 May; 1830(5):3317-28. . View in PubMed
Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. . View in PubMed
Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed
Current challenges and controversies in drug-induced liver injury Drug Saf. 2012 Dec 01; 35(12):1099-117. . View in PubMed
Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling J Chromatogr A. 2012 Oct 12; 1259:128-37. . View in PubMed
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol. 2012 Oct; 57(4):852-9. . View in PubMed
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice Hepatology. 2012 Jul; 56(1):130-9. . View in PubMed
Dealing with stress Hepatology. 2012 Jan; 55(1):3-13. . View in PubMed
c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice J Biol Chem. 2011 Oct 07; 286(40):35071-8. . View in PubMed
Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis J Hepatol. 2011 Oct; 55(4):820-7. . View in PubMed
Differential effect of gender on hepatic fat Pediatr Radiol. 2011 Sep; 41(9):1146-53. . View in PubMed
Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. . View in PubMed
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice Hepatology. 2011 Jul; 54(1):229-39. . View in PubMed
Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells J Biol Chem. 2011 Jun 24; 286(25):22047-54. . View in PubMed
Case definition and phenotype standardization in drug-induced liver injury Clin Pharmacol Ther. 2011 Jun; 89(6):806-15. . View in PubMed
The contribution of endoplasmic reticulum stress to liver diseases Hepatology. 2011 May; 53(5):1752-63. . View in PubMed
Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis J Proteome Res. 2011 Feb 04; 10(2):705-13. . View in PubMed
Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates J Biol Chem. 2010 Dec 17; 285(51):39646-54. . View in PubMed
Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria Mol Interv. 2010 Apr; 10(2):98-111. . View in PubMed
Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1 J Biol Chem. 2010 Mar 12; 285(11):8244-55. . View in PubMed
Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats Hepatology. 2010 Mar; 51(3):796-805. . View in PubMed
Signal transduction pathways involved in drug-induced liver injury Handb Exp Pharmacol. 2010; (196):267-310. . View in PubMed
Diagnosis, management and prevention of drug-induced liver injury Gut. 2009 Nov; 58(11):1555-64. . View in PubMed
Redox regulation of tumor necrosis factor signaling Antioxid Redox Signal. 2009 Sep; 11(9):2245-63. . View in PubMed
Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex Hepatology. 2009 Jun; 49(6):2001-9. . View in PubMed
Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease Am J Respir Crit Care Med. 2009 May 01; 179(9):835-42. . View in PubMed
Glutathione in liver diseases and hepatotoxicity Mol Aspects Med. 2009 Feb-Apr; 30(1-2):29-41. . View in PubMed
How to protect against acetaminophen: don't ask for JUNK Gastroenterology. 2008 Oct; 135(4):1047-51. . View in PubMed
Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates Gastroenterology. 2008 Oct; 135(4):1168-75. . View in PubMed
Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes Am J Physiol Cell Physiol. 2008 Jul; 295(1):C50-63. . View in PubMed
Clinical risk factors for portopulmonary hypertension Hepatology. 2008 Jul; 48(1):196-203. . View in PubMed
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. . View in PubMed
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury J Biol Chem. 2008 May 16; 283(20):13565-77. . View in PubMed
Endoplasmic reticulum stress and liver injury Semin Liver Dis. 2007 Nov; 27(4):367-77. . View in PubMed
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes Hepatology. 2007 Nov; 46(5):1586-96. . View in PubMed
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms J Biol Chem. 2007 Oct 05; 282(40):29470-81. . View in PubMed
Mechanisms of drug-induced liver disease Clin Liver Dis. 2007 Aug; 11(3):459-75v. . View in PubMed
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium Am J Clin Nutr. 2007 Jul; 86(1):14-24. . View in PubMed
Drug-induced liver injury Drug Saf. 2007; 30(4):277-94. . View in PubMed
Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry Hepatology. 2006 Dec; 44(6):1581-8. . View in PubMed
Current concepts and controversies in the treatment of alcoholic hepatitis World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. . View in PubMed
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model J Hepatol. 2006 Nov; 45(5):717-24. . View in PubMed
Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S7-9. . View in PubMed
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis Free Radic Biol Med. 2006 Aug 15; 41(4):627-39. . View in PubMed
Role of innate immunity in acetaminophen-induced hepatotoxicity Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. . View in PubMed
ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33.. View in PubMed
Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial JAMA. 2006 Jul 05; 296(1):87-93. . View in PubMed
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity Gastroenterology. 2006 Jul; 131(1):165-78. . View in PubMed
Mechanisms of liver injuryIII. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G1-7. . View in PubMed
Neutrophil depletion protects against murine acetaminophen hepatotoxicity Hepatology. 2006 Jun; 43(6):1220-30. . View in PubMed
Drug hepatotoxicity Clin Liver Dis. 2006 May; 10(2):207-17vii. . View in PubMed
Rules and laws of drug hepatotoxicity Pharmacoepidemiol Drug Saf. 2006 Apr; 15(4):231-3. . View in PubMed
Liver biology and pathobiology Hepatology. 2006 Feb; 43(2 Suppl 1):S235-8. . View in PubMed
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding Alcohol Clin Exp Res. 2005 Aug; 29(8):1496-503. . View in PubMed
Idiosyncratic drug hepatotoxicity Nat Rev Drug Discov. 2005 Jun; 4(6):489-99. . View in PubMed
Hepatic mitochondrial glutathione: transport and role in disease and toxicity Toxicol Appl Pharmacol. 2005 May 01; 204(3):263-73. . View in PubMed
Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis Am J Gastroenterol. 2005 Feb; 100(2):295-8. . View in PubMed
Serum alanine aminotransferase in skeletal muscle diseases Hepatology. 2005 Feb; 41(2):380-2. . View in PubMed
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity Gastroenterology. 2004 Dec; 127(6):1760-74. . View in PubMed
Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid J Hepatol. 2004 Dec; 41(6):1062-4. . View in PubMed
Statin-induced hepatotoxicity Gastroenterology. 2004 Oct; 127(4):1278; author reply 1278-9. . View in PubMed
Liver injury associated with the beta-interferons for MS Neurology. 2004 Sep 28; 63(6):1142-3; author reply 1142-3. . View in PubMed
Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury Hepatology. 2004 Aug; 40(2):442-51. . View in PubMed
Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6.. View in PubMed
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury World J Gastroenterol. 2004 Jun 15; 10(12):1699-708. . View in PubMed
Clinical perspectives on xenobiotic-induced hepatotoxicity Drug Metab Rev. 2004 May; 36(2):301-12. . View in PubMed
Drug-induced liver injury Clin Infect Dis. 2004 Mar 01; 38 Suppl 2:S44-8. . View in PubMed
Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress Biochem Pharmacol. 2004 Feb 01; 67(3):439-51. . View in PubMed
Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. . View in PubMed
Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria Mol Pharmacol. 2003 Nov; 64(5):1136-44. . View in PubMed
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion Hepatology. 2003 Sep; 38(3):692-702. . View in PubMed
Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes Hepatology. 2003 Jun; 37(6):1425-34. . View in PubMed
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice Gastroenterology. 2003 May; 124(5):1488-99. . View in PubMed
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress Gastroenterology. 2003 Mar; 124(3):708-24. . View in PubMed
2003 Jan 21; 138(2):159-60; author reply 159-60. . View in PubMed
Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance Drug Saf. 2003; 26(11):815-27. . View in PubMed
Immune-mediated drug-induced liver disease Clin Liver Dis. 2002 Aug; 6(3):755-74. . View in PubMed
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes Hepatology. 2002 Jul; 36(1):55-64. . View in PubMed
Mechanism of staurosporine-induced apoptosis in murine hepatocytes Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G825-34. . View in PubMed
The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane Mol Pharmacol. 2002 Feb; 61(2):425-35. . View in PubMed
Biochemical and cellular mechanisms of toxic liver injury Semin Liver Dis. 2002; 22(2):137-44. . View in PubMed
Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione Hepatology. 2001 Nov; 34(5):964-71. . View in PubMed
How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):171S-181S.. View in PubMed
Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses Invest Ophthalmol Vis Sci. 2001 Feb; 42(2):409-16. . View in PubMed
Drug-induced liver disorders: implications for drug development and regulation Drug Saf. 2001; 24(7):483-90. . View in PubMed
Causality assessment versus guilt-by-association in drug hepatotoxicity Hepatology. 2001 Jan; 33(1):308-10. . View in PubMed
Radiation inactivation studies of hepatic sinusoidal reduced glutathione transport system Biochim Biophys Acta. 2000 Apr 05; 1464(2):207-18. . View in PubMed
Cell death at the millenniumImplications for liver diseases. Clin Liver Dis. 2000 Feb; 4(1):1-23v. . View in PubMed
Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody J Clin Invest. 2000 Feb; 105(3):329-39. . View in PubMed
GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC Brain Res. 2000 Jan 10; 852(2):374-82. . View in PubMed
Mechanisms of liver cell injury J Hepatol. 2000; 32(1 Suppl):39-47. . View in PubMed
Avoiding hepatic injury from drugs Gastroenterology. 1999 Oct; 117(4):759. . View in PubMed
GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter J Neurochem. 1999 Jul; 73(1):390-9. . View in PubMed
Hepatotoxicity of psychotropic drugs Hepatology. 1999 May; 29(5):1347-51. . View in PubMed
Protection from oxidant injury by sodium-dependent GSH uptake in retinal Müller cells Exp Eye Res. 1999 May; 68(5):609-16. . View in PubMed
Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor Gastroenterology. 1998 Dec; 115(6):1541-51. . View in PubMed
Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes Invest Ophthalmol Vis Sci. 1998 Jul; 39(8):1379-86. . View in PubMed
Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation Am J Physiol. 1998 05; 274(5):G923-30. . View in PubMed
Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine Semin Liver Dis. 1998; 18(4):313-29. . View in PubMed
Mitochondrial glutathione: importance and transport Semin Liver Dis. 1998; 18(4):389-401. . View in PubMed
Changes in glutathione homeostasis during liver regeneration in the rat Hepatology. 1998 Jan; 27(1):147-53. . View in PubMed
Hepatotoxicity of herbal remedies: insights into the intricacies of plant-animal warfare and cell death Gastroenterology. 1997 Oct; 113(4):1408-12. . View in PubMed
Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine Hepatology. 1997 Sep; 26(3):699-708. . View in PubMed
GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect Am J Physiol. 1997 Jul; 273(1 Pt 1):G7-17. . View in PubMed
Sinusoidal endothelial cells as a target for acetaminophen toxicityDirect action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 09; 53(9):1339-45. . View in PubMed
Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium Exp Eye Res. 1997 Apr; 64(4):615-26. . View in PubMed
Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats Am J Physiol. 1997 Feb; 272(2 Pt 1):G374-82. . View in PubMed
Oxidative stress and alcoholic liver disease Alcohol Health Res World. 1997; 21(4):321-4. . View in PubMed
Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. . View in PubMed
Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats Hepatology. 1996 Jul; 24(1):253-8. . View in PubMed
Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics Am J Physiol. 1996 Jun; 270(6 Pt 1):G969-75. . View in PubMed
Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats Hepatology. 1996 Jun; 23(6):1642-9. . View in PubMed
Plasma membrane and mitochondrial transport of hepatic reduced glutathione Semin Liver Dis. 1996 May; 16(2):147-58. . View in PubMed
GSH transporters: molecular characterization and role in GSH homeostasis Biol Chem Hoppe Seyler. 1996 May; 377(5):267-73. . View in PubMed
Evidence for the existence of a sodium-dependent glutathione (GSH) transporterExpression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. . View in PubMed
Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells J Clin Invest. 1996 Mar 15; 97(6):1488-96. . View in PubMed
Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease Hepatology. 1996 Mar; 23(3):589-99. . View in PubMed
Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations Exp Eye Res. 1996 Jan; 62(1):29-37. . View in PubMed
Oxidative stress and liver disease Prog Liver Dis. 1996; 14:131-59. . View in PubMed
Mechanisms of drug-induced liver disease Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. . View in PubMed
Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes Mol Pharmacol. 1995 Nov; 48(5):825-34. . View in PubMed
Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters Toxicol Appl Pharmacol. 1995 Oct; 134(2):264-72. . View in PubMed
Molecular characterization of a reduced glutathione transporter in the lens Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. . View in PubMed
Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathioneExpression studies in Xenopus laevis oocytes. J Biol Chem. 1995 Jul 07; 270(27):15946-9. . View in PubMed
Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1495-9. . View in PubMed
Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes Hepatology. 1995 Jan; 21(1):207-14. . View in PubMed
Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye Exp Eye Res. 1994 Oct; 59(4):487-96. . View in PubMed
Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver Mol Pharmacol. 1994 Sep; 46(3):578-85. . View in PubMed
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes J Clin Invest. 1994 Jul; 94(1):193-201. . View in PubMed
Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. . View in PubMed
Role of BSP/bilirubin binding protein and bilitranslocase in glutathione uptake in rat basolateral liver plasma membrane vesicles Biochem Biophys Res Commun. 1994 Apr 29; 200(2):1079-85. . View in PubMed
Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics J Clin Invest. 1994 Apr; 93(4):1841-5. . View in PubMed
Distribution of 3 alpha-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: comparison with glutathione S-transferase subunits J Gastroenterol. 1994 Apr; 29(2):115-9. . View in PubMed
Bidirectional membrane transport of intact glutathione in Hep G2 cells Am J Physiol. 1993 Dec; 265(6 Pt 1):G1128-34. . View in PubMed
Mitochondrial glutathione depletion in alcoholic liver disease Alcohol. 1993 Nov-Dec; 10(6):469-75. . View in PubMed
Identification and purification of a human liver cytosolic tocopherol binding protein Protein Expr Purif. 1993 Oct; 4(5):382-9. . View in PubMed
Thiol-disulfide effects on hepatic glutathione transportStudies in cultured rat hepatocytes and perfused livers. J Clin Invest. 1993 Sep; 92(3):1188-97. . View in PubMed
Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles J Biol Chem. 1993 May 25; 268(15):10836-41. . View in PubMed
Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes J Biol Chem. 1993 Feb 05; 268(4):2324-8. . View in PubMed
Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats Hepatology. 1992 Dec; 16(6):1423-7. . View in PubMed
Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence J Pharmacol Exp Ther. 1992 Dec; 263(3):964-70. . View in PubMed
Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles J Biol Chem. 1992 Nov 05; 267(31):22256-64. . View in PubMed
Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the ratStudies in cultured hepatocytes and in vivo. J Clin Invest. 1992 Aug; 90(2):524-32. . View in PubMed
The relationship between biliary secretion of bilirubin and glutathione in the rat Gastroenterol Jpn. 1992 Jun; 27(3):369-73. . View in PubMed
Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals Am J Physiol. 1992 Apr; 262(4 Pt 1):G669-76. . View in PubMed
Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol J Lipid Res. 1992 Mar; 33(3):343-50. . View in PubMed
Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion Hepatology. 1992 Mar; 15(3):507-14. . View in PubMed
Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats J Biol Chem. 1992 Jan 25; 267(3):1667-73. . View in PubMed
Zonal distribution of cysteine uptake in the perfused rat liver J Biol Chem. 1992 Jan 05; 267(1):192-6. . View in PubMed
Effect of phorone and allopurinol on ischemia-reperfusion injury in gastrointestinal mucosa of the rat Pharmacology. 1992; 44(6):334-43. . View in PubMed
Glutathione metabolism and its role in hepatotoxicity Pharmacol Ther. 1991 Dec; 52(3):287-305. . View in PubMed
Effect of indomethacin on the uptake, metabolism and excretion of 3-oxocholic acid: studies in isolated hepatocytes and perfused rat liver Biochim Biophys Acta. 1991 Jul 30; 1084(3):247-50. . View in PubMed
Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat J Clin Invest. 1991 Jul; 88(1):260-9. . View in PubMed
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed ratsTracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest. 1991 Feb; 87(2):397-405. . View in PubMed
The use of monochlorobimane to determine hepatic GSH levels and synthesis Anal Biochem. 1990 Nov 01; 190(2):212-9. . View in PubMed
Importance and regulation of hepatic glutathione Semin Liver Dis. 1990 Nov; 10(4):251-66. . View in PubMed
Hormonal regulation of glutathione efflux J Biol Chem. 1990 Sep 25; 265(27):16088-95. . View in PubMed
Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ Am J Physiol. 1990 Jun; 258(6 Pt 1):G967-73. . View in PubMed
Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat J Clin Invest. 1990 Jun; 85(6):2009-13. . View in PubMed
Calcium compartmentation and exchange rates in primary hepatocyte culture Anal Biochem. 1990 May 15; 187(1):187-96. . View in PubMed
Oxidation and reduction of bile acid precursors by rat hepatic 3 alpha-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin Biochim Biophys Acta. 1990 Apr 02; 1043(2):153-6. . View in PubMed
Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver J Biol Chem. 1990 Feb 05; 265(4):2132-6. . View in PubMed
The use of isolated perfused liver in studies of biological transport processes Methods Enzymol. 1990; 192:485-95. . View in PubMed
Effects of chronic ethanol feeding on rat hepatocytic glutathioneRelationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest. 1989 Apr; 83(4):1247-52. . View in PubMed
Tocopherol-binding proteins of hepatic cytosol Ann N Y Acad Sci. 1989; 570:85-94. . View in PubMed
Role of glutathione status in protection against ethanol-induced gastric lesions Pharmacology. 1989; 38(1):57-60. . View in PubMed
The role of cytoplasmic proteins in hepatic bile acid transport Annu Rev Physiol. 1989; 51:161-76. . View in PubMed
Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes Am J Physiol. 1988 Oct; 255(4 Pt 1):G403-8. . View in PubMed
Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubinKinetics, sidedness, and molecular forms. J Clin Invest. 1988 Aug; 82(2):608-16. . View in PubMed
Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases Biochim Biophys Acta. 1988 Apr 28; 954(1):37-43. . View in PubMed
Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids J Lipid Res. 1988 Mar; 29(3):279-86. . View in PubMed
Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver Biochem Pharmacol. 1987 Nov 15; 36(22):4015-7. . View in PubMed
Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenaseII. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):861-6. . View in PubMed
Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenaseI. Studies with the purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):852-60. . View in PubMed
Effect of chronic ethanol feeding on rat hepatocytic glutathioneCompartmentation, efflux, and response to incubation with ethanol. J Clin Invest. 1987 Jul; 80(1):57-62. . View in PubMed
A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army N Engl J Med. 1987 Apr 16; 316(16):965-70. . View in PubMed
Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver Biochem Biophys Res Commun. 1987 Feb 27; 143(1):377-82. . View in PubMed
3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosolIdentification, kinetics, and physiologic significance. J Clin Invest. 1987 Feb; 79(2):427-34. . View in PubMed
Subunit heterogeneity of cationic human hepatic glutathione S-transferases Pharmacology. 1987; 35(2):65-78. . View in PubMed
Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein Arch Biochem Biophys. 1986 Nov 15; 251(1):385-92. . View in PubMed
Purification of a 325 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids. FEBS Lett. 1986 Oct 27; 207(2):193-7. . View in PubMed
Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes Am J Physiol. 1986 Sep; 251(3 Pt 1):G354-61. . View in PubMed
Binding of bile acids by glutathione S-transferases from rat liver J Lipid Res. 1986 Sep; 27(9):955-66. . View in PubMed
Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids J Lipid Res. 1986 Jun; 27(6):652-7. . View in PubMed
Drug-induced hepatotoxicity Ann Intern Med. 1986 Jun; 104(6):826-39. . View in PubMed
Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution Hepatology. 1986 May-Jun; 6(3):433-9. . View in PubMed
Kinetics of glutathione efflux from isolated rat hepatocytes Am J Physiol. 1986 Feb; 250(2 Pt 1):G236-43. . View in PubMed
Organic anion-binding by human hepatic GSH S-transferases Biochem Pharmacol. 1986 Jan 15; 35(2):354-6. . View in PubMed
Gamma-glutamylcysteine: a substrate for glutathione S-transferases Biochem Pharmacol. 1985 Oct 15; 34(20):3643-7. . View in PubMed
Modulating effect of thiol-disulfide status on [14C]aminopyrine accumulation in the isolated parietal cell J Biol Chem. 1985 Jul 05; 260(13):8020-5. . View in PubMed
Acetaldehyde-dependent oxidation of glutathione catalyzed by rat liver cytosol Biochem Biophys Res Commun. 1985 Jun 28; 129(3):949-57. . View in PubMed
Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial JPEN J Parenter Enteral Nutr. 1985 May-Jun; 9(3):288-95. . View in PubMed
Sinusoidal efflux of glutathione in the perfused rat liverEvidence for a carrier-mediated process. J Clin Invest. 1985 Jan; 75(1):258-65. . View in PubMed
The regulation of hepatic glutathione Annu Rev Pharmacol Toxicol. 1985; 25:715-44. . View in PubMed
Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosol Biochem J. 1984 Dec 15; 224(3):947-53. . View in PubMed
Identification and purification of a 36 kDa bile acid binder in human hepatic cytosol FEBS Lett. 1984 Nov 05; 177(1):31-5. . View in PubMed
Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin J Lipid Res. 1984 Nov; 25(11):1177-83. . View in PubMed
Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin Biochem Pharmacol. 1984 Nov 01; 33(21):3511-3. . View in PubMed
Comparison of binding of thyroid hormone analogues to hepatic organic anion binding proteins Biochim Biophys Acta. 1984 Sep 28; 801(2):184-8. . View in PubMed
Role of glutathione in gastric mucosal cytoprotection Am J Physiol. 1984 Sep; 247(3 Pt 1):G296-304. . View in PubMed
Inhibition of glutathione efflux from isolated rat hepatocytes by methionine J Biol Chem. 1984 Aug 10; 259(15):9355-8. . View in PubMed
Quantitation and characterization of a newly described organic anion binder by radioimmunoassay Biochim Biophys Acta. 1984 Jul 30; 800(2):171-7. . View in PubMed
Binding of glutathione by rat liver cytosol Pharmacology. 1984; 28(2):61-6. . View in PubMed
Newly identified bile acid binders in rat liver cytosolPurification and comparison with glutathione S-transferases. J Biol Chem. 1983 Mar 25; 258(6):3602-7. . View in PubMed
Factors influencing the efflux of hepatic glutathione into bile in rats J Pharmacol Exp Ther. 1983 Jan; 224(1):141-7. . View in PubMed
Newly identified organic anion-binding proteins in rat liver cytosol Biochim Biophys Acta. 1982 Dec 20; 709(2):342-52. . View in PubMed
Propylthiouracil treatment for alcoholic hepatitis: should it and does it work? Gastroenterology. 1982 Jun; 82(6):1468-71.. View in PubMed
Identification of hepatic Z-protein in a marine elasmobranch, Platyrhinoides triseriata Biochem J. 1982 May 01; 203(2):377-81. . View in PubMed
Glutathione S-transferases in elasmobranch liverMolecular heterogeneity, catalytic and binding properties, and purification. Biochem J. 1981 Dec 01; 199(3):749-56. . View in PubMed
The importance and regulation of hepatic glutathione Yale J Biol Med. 1981 Nov-Dec; 54(6):497-502. . View in PubMed
Inhibition of rat hepatic thyroxine 5'-monodeiodinase by propylthiouracil: relation to site of interaction of thyroxine and glutathione J Endocrinol Invest. 1981 Oct-Dec; 4(4):379-87. . View in PubMed
The hepatocellular uptake and biliary excretion of endotoxin in the rat Hepatology. 1981 Sep-Oct; 1(5):401-7. . View in PubMed
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis Hepatology. 1981 Sep-Oct; 1(5):431-5. . View in PubMed
Halothane-induced hepatic disease Semin Liver Dis. 1981 May; 1(2):134-42. . View in PubMed
Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats J Biol Chem. 1981 Mar 10; 256(5):2115-7. . View in PubMed
Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells Endocrinology. 1981 Mar; 108(3):970-6. . View in PubMed
Direct protection against acetaminophen hepatotoxicity by propylthiouracilIn vivo and in vitro studies in rats and mice. J Clin Invest. 1981 Mar; 67(3):688-95. . View in PubMed
Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis Hepatology. 1981 Jan-Feb; 1(1):65-72. . View in PubMed
Extrahepatic obstruction in chronic alcoholic pancreatitis Alcohol Clin Exp Res. 1981 Jan; 5(1):110-8. . View in PubMed
Physiological significance of glutathione S-transferases Am J Physiol. 1980 Dec; 239(6):G439-44. . View in PubMed
Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in the rat Gastroenterology. 1980 Sep; 79(3):545-9. . View in PubMed
Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine J Chromatogr. 1980 Jun 27; 194(3):424-8. . View in PubMed
Bile acid tolerance tests: rationale Gastroenterology. 1980 Jun; 78(6):1654-5. . View in PubMed
Inhibition of hepatic metabolism of azathioprine by furosemide in human liver in vitro Biochem Pharmacol. 1980 May 15; 29(10):1439-41. . View in PubMed
PropylthiouracilA substrate for the glutathione S-transferases that competes with glutathione. J Biol Chem. 1980 Apr 25; 255(8):3508-13. . View in PubMed
Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat Biochem Pharmacol. 1980 Apr 15; 29(8):1205-8. . View in PubMed
Effect of salicylates and phenobarbital on hepatic glutathione in the rat J Pharmacol Exp Ther. 1980 Feb; 212(2):240-5. . View in PubMed
Common bile duct stenosis from chronic pancreatitis: a clinical and pathologic spectrum Medicine (Baltimore). 1979 Nov; 58(6):385-412. . View in PubMed
Pruritus, cimetidine and polycythemia N Engl J Med. 1979 02 22; 300(8):433-4. . View in PubMed
Significance of microscopic cholangitis in alcoholic liver disease Gastroenterology. 1978 Dec; 75(6):1045-50. . View in PubMed
Aplastic anemia associated with type B viral hepatitis Arch Intern Med. 1978 Oct; 138(10):1557-8. . View in PubMed
Cholestatic liver disease Hosp Pract. 1978 Aug; 13(8):83-92. . View in PubMed
Obstructive jaundice caused by hepatocellular carcinomaReport of three cases. Am J Dig Dis. 1978 Jul; 23(7):609-17. . View in PubMed
The effect of phenobarbital, probenecid and diethyl maleate on the pharmaco-kinetics and biliary excretion of ethacrynic acid in the rat J Pharmacol Exp Ther. 1978 May; 205(2):471-9. . View in PubMed
Glutathione S-transferase in human lymphoid cell lines and fractionated peripheral leucocytes Biochem J. 1978 Mar 01; 169(3):465-70. . View in PubMed
Inhibition of hepatic metabolism of azathioprine in vivo Gastroenterology. 1978 Jan; 74(1):90-2. . View in PubMed
Effect of dietary phenobarbital, 3,4-benzo(alpha)pyrene and 3-methylcholanthrene on hepatic, intestinal and renal glutathione s-transferase activities in the rat Biochem Pharmacol. 1978; 27(8):1284-7. . View in PubMed
Endocrine and metabolic alterations with food and water deprivation Am J Clin Nutr. 1977 Dec; 30(12):1953-62. . View in PubMed
The glutathione S-transferases of the small intestine in the rat Cancer Res. 1977 Mar; 37(3):788-91. . View in PubMed
Interaction of azathioprine and glutathione in the liver of the rat J Pharmacol Exp Ther. 1977 Mar; 200(3):479-86. . View in PubMed
Metabolic clearance of furosemide in the rat J Pharmacol Exp Ther. 1977 Jan; 200(1):52-7. . View in PubMed
Enzymatic thiolysis of azathioprine in vitro Biochem Pharmacol. 1976 Nov 01; 25(21):2421-6. . View in PubMed
Comparison of renal and hepatic glutathione S-transferases in the rat Biochem J. 1976 Aug 15; 158(2):243-8. . View in PubMed
Drug induction and sex differences of renal glutathione S-transferases in the rat Biochem J. 1975 Aug; 150(2):259-62. . View in PubMed
Hepatic glutathione S-transferases: identification by gel filtration and in vitro inhibition by organic anions Proc Soc Exp Biol Med. 1975 May; 149(1):234-7. . View in PubMed
Drug induction of hepatic glutathione S-transferases in male and female rats* Biochem J. 1975 Feb; 146(2):351-6. . View in PubMed
Malabsorption secondary to mesenteric ischemia Am J Roentgenol Radium Ther Nucl Med. 1973 Oct; 119(2):352-8. . View in PubMed
Role of hepatic anion-binding protein in bromsulphthalein conjugation J Exp Med. 1973 Aug 01; 138(2):483-7. . View in PubMed
Postprandial serum bile acid for the detection of hepatobiliary disease JAMA. 1973 Jul 16; 225(3):292-3. . View in PubMed
Hepatobiliary diseases associated with serum antimitochondrial antibody (AMA) Am J Med. 1973 Jun; 54(6):725-30. . View in PubMed
Quantitative analysis of unconjugated and conjugated bile acids in duodenal fluid by densitometry after paper electrophoresis J Lipid Res. 1973 Mar; 14(2):224-8. . View in PubMed
Coproporphyrin I and 3 excretion in bile and urine J Clin Invest. 1972 Nov; 51(11):2895-9. . View in PubMed
Isolation of erythrocytes with normal protoporphyrin levels in erythropoietic protoporphyria N Engl J Med. 1968 May 16; 278(20):1077-81. . View in PubMed
Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.