Author Correction: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells Exp Mol Med. 2024 Oct 28. . View in PubMed

Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2024 Oct 01; 134(19). . View in PubMed

NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells Exp Mol Med. 2024 Feb; 56(2):461-477. . View in PubMed

Protocol for generation of humanized HCC mouse model and cancer-driver mutations using CRISPR-Cas9 STAR Protoc. 2023 Dec 15; 4(4):102389. . View in PubMed

Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal iScience. 2023 Jul 21; 26(7):107035. . View in PubMed

MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells Cell Death Discov. 2023 Apr 28; 9(1):141. . View in PubMed

LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells iScience. 2023 Mar 17; 26(3):106254. . View in PubMed

Profiling of Circulating Tumor Cells for Screening of Selective Inhibitors of Tumor-Initiating Stem-Like Cells Adv Sci (Weinh). 2023 05; 10(14):e2206812. . View in PubMed

GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage Viruses. 2023 05 06; 15(5). . View in PubMed

ß-CATENIN stabilizes HIF2 through lncRNA and inhibits intravenous immunoglobulin immunotherapy Front Immunol. 2023; 14:1204907. . View in PubMed

Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - ß-catenin cascade to promote liver tumorigenesis Nat Commun. 2023 05 08; 14(1):2651. . View in PubMed

Gut-derived Endotoxin-TLR4 Signaling Drives MYC-Ig Translocation to Promote Lymphoproliferation through c-JUN and STAT3 Activation Mol Cancer Res. 2023 02 01; 21(2):155-169. . View in PubMed

c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity iScience. 2022 Jun 17; 25(6):104325. . View in PubMed

Immunotherapy and Microbiota for Targeting of Liver Tumor-Initiating Stem-like Cells Cancers (Basel). 2022 May 12; 14(10). . View in PubMed

Activated and nonactivated MSCs increase survival in humanized mice after acute liver injury through alcohol binging Hepatol Commun. 2022 07; 6(7):1549-1560. . View in PubMed

A review of alcohol-pathogen interactions: New insights into combined disease pathomechanisms Alcohol Clin Exp Res. 2022 03; 46(3):359-370. . View in PubMed

State of the art treatment of hepatitis B virus hepatocellular carcinoma and the role of hepatitis B surface antigen post-liver transplantation and resection Liver Int. 2022 02; 42(2):288-298. . View in PubMed

The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein Nat Commun. 2022 11 14; 13(1):6551. . View in PubMed

HCV and tumor-initiating stem-like cells Front Physiol. 2022; 13:903302. . View in PubMed

DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma Cancer Lett. 2022 11 01; 548:215899. . View in PubMed

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection J Biol Chem. 2021 Jan-Jun; 296:100759. . View in PubMed

Cell fate, metabolic reprogramming and lncRNA of tumor-initiating stem-like cells induced by alcohol Chem Biol Interact. 2020 May 25; 323:109055. . View in PubMed

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs Nat Commun. 2020 06 17; 11(1):3084. . View in PubMed

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance Nat Commun. 2019 04 12; 10(1):1693. . View in PubMed

Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance J Virol. 2019 04 15; 93(8). . View in PubMed

Pluripotency Transcription Factors and Metabolic Reprogramming of Mitochondria in Tumor-Initiating Stem-like Cells Antioxid Redox Signal. 2018 Apr 10; 28(11):1080-1089. . View in PubMed

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading Redox Biol. 2018 04; 14:164-177. . View in PubMed

NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells Adv Exp Med Biol. 2018; 1032:105-113. . View in PubMed

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem CellsMol Cell. 2017 Oct 19; 68(2):281-292. e5. . View in PubMed

Existence of cancer stem cells in hepatocellular carcinoma: myth or reality? Hepatol Int. 2017 Mar; 11(2):143-147.. View in PubMed

Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability Hepatology. 2017 02; 65(2):678-693. . View in PubMed

Wnt/ß-catenin activation and macrophage induction during liver cancer development following steatosis Oncogene. 2017 10 26; 36(43):6020-6029. . View in PubMed

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B72. Nat Commun. 2017 01 09; 8:13882. . View in PubMed

TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice Gastroenterology. 2016 Mar; 150(3):707-19. . View in PubMed

TGF-ß/ß2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome J Clin Invest. 2016 Feb; 126(2):527-42. . View in PubMed

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism Cell Metab. 2016 Jan 12; 23(1):206-19. . View in PubMed

NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer Hepatology. 2015 Nov; 62(5):1466-79. . View in PubMed

Iterative tyrosine phosphorylation controls non-canonical domain utilization in Crk Oncogene. 2015 Aug 06; 34(32):4260-9. . View in PubMed

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers Nat Commun. 2015 Aug 03; 6:7839. . View in PubMed

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma Clin Sci (Lond). 2015 Jun; 128(11):761-74. . View in PubMed

Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity Oncogene. 2015 May 14; 34(20):2650-9. . View in PubMed

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice Hepatology. 2015 Jan; 61(1):129-40. . View in PubMed

TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis Adv Exp Med Biol. 2015; 815:131-44. . View in PubMed

Alcohol, TLR4-TGF-ß antagonism, and liver cancer Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. . View in PubMed

Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity Hepatol Int. 2014 Jul; 8(3):330-8. . View in PubMed

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure FEBS Open Bio. 2014; 4:777-87. . View in PubMed

HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases PLoS One. 2014; 9(6):e98521. . View in PubMed

Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2013 Jul; 123(7):2832-49. . View in PubMed

Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus Drug Deliv Transl Res. 2013 Apr; 3(2):152-64. . View in PubMed

PPARs and Liver Disease PPAR Res. 2013; 2013:896412. . View in PubMed

The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex PLoS One. 2013; 8(2):e57312. . View in PubMed

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry J Biol Chem. 2012 Dec 07; 287(50):41922-30. . View in PubMed

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol. 2012 Oct; 57(4):852-9. . View in PubMed

Replication of hepatitis C virus RNA on autophagosomal membranes J Biol Chem. 2012 May 25; 287(22):18036-43. . View in PubMed

Mouse intragastric infusion (iG) model Nat Protoc. 2012 Mar 29; 7(4):771-81. . View in PubMed

Morphogens and hepatic stellate cell fate regulation in chronic liver disease J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. . View in PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. . View in PubMed

Hepatitis C virus translation preferentially depends on active RNA replication PLoS One. 2012; 7(8):e43600. . View in PubMed

A super TLR agonist to improve efficacy of dendritic cell vaccine in induction of anti-HCV immunity PLoS One. 2012; 7(11):e48614. . View in PubMed

Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation Oncogene. 2011 Nov 17; 30(46):4645-55. . View in PubMed

Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64 J Virol. 2011 Oct; 85(20):10899-904. . View in PubMed

Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-? secretion activity. J Gastroenterol. 2011 Feb; 46(2):232-41.. View in PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed

Hepatitis C virus-related lymphomagenesis in a mouse model ISRN Hematol. 2011; 2011:167501. . View in PubMed

Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation Oncogene. 2010 Dec 02; 29(48):6378-89. . View in PubMed

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes J Immunol. 2010 Dec 01; 185(11):6985-98. . View in PubMed

Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression J Biol Chem. 2010 Nov 12; 285(46):35359-73. . View in PubMed

Hepatitis C virus egress and release depend on endosomal trafficking of core protein J Virol. 2010 Nov; 84(21):11590-8. . View in PubMed

Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage Alcohol Clin Exp Res. 2010 Oct; 34(10):1675-86. . View in PubMed

Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A J Virol. 2010 Aug; 84(16):7983-93. . View in PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed

TLRs, Alcohol, HCV, and Tumorigenesis Gastroenterol Res Pract. 2010; 2010:518674. . View in PubMed

Toll-like receptor signaling in liver diseases Gastroenterol Res Pract. 2010; 2010:971270. . View in PubMed

Hepatitis C virus causes uncoupling of mitotic checkpoint and chromosomal polyploidy through the Rb pathway J Virol. 2009 Dec; 83(23):12590-600. . View in PubMed

Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1 J Immunol. 2009 Nov 01; 183(9):5964-76. . View in PubMed

Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukinsGastroenterology. 2009 Jul; 137(1):285-96296. e1-11. . View in PubMed

"Second hit" models of alcoholic liver disease Semin Liver Dis. 2009 May; 29(2):178-87. . View in PubMed

SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication Virology. 2009 Apr 10; 386(2):249-56. . View in PubMed

Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6 J Infect Dis. 2009 Mar 01; 199(5):726-36. . View in PubMed

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. . View in PubMed

Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A J Virol. 2008 Sep; 82(17):8838-48. . View in PubMed

Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein J Virol. 2008 Jul; 82(13):6711-20. . View in PubMed

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation Virology. 2008 Jan 20; 370(2):295-309. . View in PubMed

Bulk electronic structure of the antiferromagnetic superconducting phase in ErNi2B2C Phys Rev Lett. 2008 Jan 11; 100(1):017003. . View in PubMed

Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies Curr Top Microbiol Immunol. 2008; 317:1-38. . View in PubMed

Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines Virology. 2007 Apr 25; 361(1):161-73. . View in PubMed

HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice Hepatology. 2006 Oct; 44(4):936-44. . View in PubMed

Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation J Virol. 2006 Jul; 80(14):7199-207. . View in PubMed

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6 J Virol. 2006 Jan; 80(2):866-74. . View in PubMed

Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells J Virol. 2005 Jul; 79(13):8079-89. . View in PubMed

Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes J Virol. 2004 Aug; 78(16):8835-43. . View in PubMed

Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4262-7. . View in PubMed

Cynomolgus monkey did not hyperacutely reject skin xenograft of N-acetylglucosaminyltransferase III gene transgenic pig Transplant Proc. 2003 Feb; 35(1):518. . View in PubMed

Secoiridoid glycosides from Gentiana scabra J Nat Prod. 2001 Dec; 64(12):1574-5. . View in PubMed

Intranephron localization and regulation of the V1a vasopressin receptor during chronic metabolic acidosis and dehydration in rats Pflugers Arch. 2001 Aug; 442(5):652-61. . View in PubMed

Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner Mol Biol Cell. 2001 Jun; 12(6):1859-68. . View in PubMed

Studies on the constituents of Catalpa speciesVI. Monoterpene glycosides from the fallen leaves of Catalpa ovata G. Don. Chem Pharm Bull (Tokyo). 2001 Jun; 49(6):732-6. . View in PubMed

New sterols and triterpenoids from four edible mushrooms Chem Pharm Bull (Tokyo). 2001 May; 49(5):589-94. . View in PubMed

Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins J Biol Chem. 2001 Apr 13; 276(15):12140-6. . View in PubMed

Secoiridoid glycosides from the flower buds of Lonicera japonica Phytochemistry. 2000 Dec; 55(8):879-81. . View in PubMed

Structures of new ceramides from the fruit bodies of Grifola frondosa Chem Pharm Bull (Tokyo). 2000 Sep; 48(9):1356-8. . View in PubMed

Protective effects of alpha-tocopherol and beta-carotene on para-nonylphenol-induced inhibition of cell growth, cellular respiration and glucose-induced proton extrusion of bacteria FEMS Microbiol Lett. 2000 Jun 15; 187(2):161-5. . View in PubMed

Studies of the constituents of Gardenia speciesII. Terpenoids from Gardeniae Fructus. Chem Pharm Bull (Tokyo). 2000 May; 48(5):746-8. . View in PubMed

Protective effect of antioxidants against para-nonylphenol-induced inhibition of cell growth in Saccharomyces cerevisiae FEMS Microbiol Lett. 2000 Apr 01; 185(1):65-70. . View in PubMed

v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells Oncogene. 2000 Mar 23; 19(13):1710-8. . View in PubMed

Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A Oncogene. 2000 Jan 13; 19(2):273-9. . View in PubMed

Farnesol-induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F(0)F(1)-ATPase in yeast FEBS Lett. 1999 Nov 26; 462(1-2):108-12. . View in PubMed

Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1 Oncogene. 1999 Nov 11; 18(47):6555-63. . View in PubMed

Lung cancer in patients who had received thoracoplasty for pulmonary tuberculosis Jpn J Clin Oncol. 1999 Nov; 29(11):541-5. . View in PubMed

UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp517-02. IV. Comparative studies of UK-2A with antimycin A3 on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells. J Antibiot (Tokyo). 1999 May; 52(5):480-4. . View in PubMed

Hyaluronan activates mitogen-activated protein kinase via Ras-signaling pathway Int J Oncol. 1999 Apr; 14(4):733-8. . View in PubMed

Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae J Bacteriol. 1998 Sep; 180(17):4460-5. . View in PubMed

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA Virology. 1997 Oct 27; 237(2):270-82. . View in PubMed

[Diagnostic accuracy of 201T1 SPECTMRI in brain diseases and inter-reader variance of diagnostic performance]. Kaku Igaku. 1996 Sep; 33(9):943-52. . View in PubMed

Dietary analysis of Japanese patients with chronic pancreatitis in stable conditions J Gastroenterol. 1994 Dec; 29(6):756-62. . View in PubMed

Seasonal development of Leptotrombidium pallidum (Acari: Trombiculidae) observed by experimental rearing in the natural environment J Med Entomol. 1993 Mar; 30(2):320-5. . View in PubMed

Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit Biochem Int. 1992 Sep; 27(6):1051-7. . View in PubMed

Aggregated distribution of infective spots composed of Leptotrombidium pallidum, highly prevalent with Rickettsia tsutsugamushi, demonstrated by sentinel voles, Microtus montebelli, on the ground Jpn J Exp Med. 1990 Dec; 60(6):325-35. . View in PubMed

A missense mutation found in human lactate dehydrogenase-B (H) variant gene Biochem Biophys Res Commun. 1990 Apr 30; 168(2):672-6. . View in PubMed